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AB194504

Anti-PDGFC antibody - C-terminal

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(1 Publication)

Mouse Polyclonal PDGFC antibody. C-terminal. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PDGFC aa 200 to C-terminus.

View Alternative Names

SCDGF, UNQ174/PRO200, PDGFC, Platelet-derived growth factor C, PDGF-C, Fallotein, Spinal cord-derived growth factor, VEGF-E

2 Images
Western blot - Anti-PDGFC antibody - C-terminal (AB194504)
  • WB

Supplier Data

Western blot - Anti-PDGFC antibody - C-terminal (AB194504)

All lanes:

Western blot - Anti-PDGFC antibody - C-terminal (ab194504) at 1/500 dilution

All lanes:

293 cell lysate at 50 µg

Predicted band size: 39 kDa

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Western blot - Anti-PDGFC antibody - C-terminal (AB194504)
  • WB

Supplier Data

Western blot - Anti-PDGFC antibody - C-terminal (AB194504)

Predicted MWt of immunogen : 38.21 KDa.

All lanes:

Western blot - Anti-PDGFC antibody - C-terminal (ab194504) at 1/1000 dilution

All lanes:

recombinant Human PDGFC protein (immunogen) at 0.2 µg

Predicted band size: 39 kDa

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Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human PDGFC aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9NRA1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2500", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Constituents: 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein PDGFC also called Platelet-Derived Growth Factor C functions mechanically as a growth factor involved in cell proliferation migration and survival. It belongs to the PDGF family and exhibits a molecular mass of approximately 38 kDa. PDGFC expresses in a variety of tissues such as the heart kidney and skeletal muscle. Unlike other PDGF family members PDGFC has a unique hinge region that requires proteolytic activation to reveal its growth factor activity.
Biological function summary

PDGFC supports angiogenesis and tissue remodeling which are essential for normal developmental processes and wound healing. It often forms part of a PDGF receptor-ligand complex by binding to the alpha and beta PDGF receptors. Upon binding PDGFC activates signaling pathways that result in cellular responses significant in tissues undergoing repair or in presence of injury.

Pathways

PDGFC plays a part in the MAPK and PI3K/AKT signaling pathways which regulate several cellular mechanisms. As it interacts with PDGF receptors PDGFC can collaborate with other proteins such as PDGFA and PDGFB both of which are significant for initiating similar pathways. These connections allow PDGFC to influence processes like cell cycle progression and apoptosis key elements in maintaining cellular homeostasis.

Alterations in PDGFC expression or signaling link to certain conditions such as cancer and fibrotic diseases. Overexpression of PDGFC relates to tumor growth and metastasis partially due to its role in angiogenesis where it can interact with proteins like VEGF. In fibrosis PDGFC acts by promoting excessive extracellular matrix production further involving it with proteins like transforming growth factor-beta (TGF-β) which contribute to tissue scarring and organ dysfunction.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages : inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.
See full target information PDGFC
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular medicine 38:1734-1742 PubMed27748839

2016

TRIM16 suppresses the progression of prostate tumors by inhibiting the Snail signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Li Qi,Zhong Lu,Yong-Hong Sun,Hai-Tao Song,Wei-Kang Xu
View all publications
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