JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB220745

Anti-PDGFRL antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Rabbit Polyclonal PDGFRL antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PDGFRL aa 200 to C-terminus.

View Alternative Names

PRLTS, PDGFRL, Platelet-derived growth factor receptor-like protein, PDGFR-like protein, PDGF receptor beta-like tumor suppressor

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-PDGFRL antibody (AB220745)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-PDGFRL antibody (AB220745)

Immunofluorescent analysis of PFA-fixed/Triton X-100 permeabilized A549 cells labeling PDGFRL with ab220745 at 4 μg/ml (green).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human PDGFRL aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q15198

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cynomolgus monkey": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PDGFRL known as Platelet-Derived Growth Factor Receptor-like protein has a mass of approximately 42 kDa. It is not a typical receptor but it resembles PDGF receptors at the molecular level. PDGFRL is expressed widely in various tissues with significant presence in normal cells like fibroblasts and endothelial cells. Unlike classic PDGF receptors that signal from the cell membrane PDGFRL is more involved in cytoplasmic processes.
Biological function summary

The function of PDGFRL remains less understood compared to other PDGF family members. Its structure suggests involvement in modulating PDGF signaling without intrinsic kinase activity. PDGFRL interactions might not form standard receptor-ligand complexes but rather influence PDGF receptor pathways indirectly. Research implies it plays a role in body development and cell growth by influencing PDGF receptor interactions.

Pathways

Studies point out PDGFRL’s involvement in cellular processes such as cell proliferation and tissue regeneration. PDGF signaling pathways where PDGFRL can act involve MAPK/ERK and PI3K/AKT both essential for various cellular responses. PDGFRL may interact with other proteins in these pathways affecting the overall signaling cascade without activating it directly serving more as a modulatory molecule.

Researchers have associated PDGFRL with certain cancers such as gastric carcinoma and meningiomas potentially due to its role in regulating cell growth. Changes in PDGFRL expression or function might alter PDGF-A and PDGF-B mediated pathways contributing to abnormal cell proliferation. PDGFRL's relation to these conditions highlights its importance as a potential marker for diagnosis or a target for therapeutic strategies.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

See full target information PDGFRL
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 16:6573-6581 PubMed30405797

2018

Therapeutic effects of lenvatinib in combination with rAd-p53 for the treatment of non-small cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Renzhi Yu,Minghuan Wang,Xiuli Zhu,Zhe Sun,Aiying Jiang,Huixin Yao

Experimental and therapeutic medicine 16:1216-1224 PubMed30116372

2018

Application of a novel targeting nanoparticle contrast agent combined with magnetic resonance imaging in the diagnosis of intraductal papillary mucinous neoplasm.

Applications

Unspecified application

Species

Unspecified reactive species

Min Sun,Liqing Kang,Yanchao Cui,Guoce Li
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB305065

Anti-Plzf antibody [EPR24830-8] - BSA and Azide free

RabMAb|Recombinant

Western blot - Anti-Plzf antibody [EPR24830-8] - BSA and Azide free (AB305065)

  • 0
  • 0
Primary Antibodies

AB220830

Anti-VRK3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VRK3 antibody (AB220830)

  • 0
  • 0
Primary Antibodies

AB224239

Anti-TAZ antibody

Immunocytochemistry/ Immunofluorescence - Anti-TAZ antibody (AB224239)

  • 1
  • 1
Primary Antibodies

AB46154

Anti-VEGFA antibody

Lab Essentials

Western blot - Anti-VEGFA antibody (AB46154)

  • 5
  • 29

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com