AB68220

Anti-PDLIM2 antibody

Name: Anti-PDLIM2 antibody (ab68220) | Abcam
Brand: Abcam Limited
SKU: AB68220

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(4 Publications)

Mouse Polyclonal PDLIM2 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PDLIM2.

View Alternative Names

PP6345, PDLIM2, PDZ and LIM domain protein 2, PDZ-LIM protein mystique

2 Images

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Western blot - Anti-PDLIM2 antibody (AB68220)

All lanes:

Western blot - Anti-PDLIM2 antibody (ab68220) at 1/500 dilution

All lanes:

human liver tissue lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Predicted band size: 37 kDa

Observed band size: 38 kDa

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Unknown

Western blot - Anti-PDLIM2 antibody (AB68220)

All lanes:

Western blot - Anti-PDLIM2 antibody (ab68220) at 1/500 dilution

Lane 1:

PDLIM2 transfected 293T cell lysate at 25 µg

Lane 2:

Non-transfected 293T cell lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Predicted band size: 37 kDa

Observed band size: 36 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

applications

Immunogen

Recombinant Full Length Protein corresponding to Human PDLIM2.

Q96JY6

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Reactivity data

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Storage buffer

pH: 7.4 Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PDLIM2 also known as Mystique or SLIM is a cytoskeletal protein that plays a role in linking actin filaments to various cellular structures. It contains a PDZ domain and a LIM domain which enable it to perform its function within the cell. PDLIM2 has a molecular mass of approximately 36 kDa. It is expressed in several tissue types including immune cells skeletal muscle and epithelial cells indicating its involvement in multiple cellular processes.

Biological function summary

PDLIM2 regulates the stability and activity of certain transcription factors and signaling molecules. It acts as an adapter protein to modulate the interaction of actin filaments with these factors. This protein also influences cell motility and adhesion acting as a critical component of a complex involving the actin cytoskeleton. Its regulation of signal transduction and transcription impacts cellular responses and maintenance of tissue integrity.

Pathways

PDLIM2 plays a central role in the NF-kB signaling pathway and the STAT pathway. By controlling the degradation and transport of nuclear factor NF-kB PDLIM2 affects immune responses and inflammation. Similarly it modulates STAT family proteins involved in pathways that trigger responses to cytokines and growth factors. PDLIM2 interacts with proteins such as RelA and STAT3 indicating its function in cell signaling and gene expression regulation.

PDLIM2 links to cancer and autoimmune disorders through its regulatory effects on inflammation and immune responses. Altered expression or function of PDLIM2 can contribute to the progression of certain cancers where it often interacts with oncogenic pathways. Additionally PDLIM2's involvement with proteins like NF-kB and STAT3 associates it with chronic inflammatory and autoimmune diseases further demonstrating its impact on pathological conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.

See full target information PDLIM2

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Infection and immunity 89:e0012821 PubMed34228504

2021

Central Nervous System-Infecting Pathogens Escherichia coli and Cryptococcus neoformans Exploit the Host Pdlim2 for Intracellular Traversal and Exocytosis in the Blood-Brain Barrier.

Applications

Unspecified application

Species

Unspecified reactive species

Zhongming Li,Vincent M Bruno,Kwang Sik Kim

Toxicology letters 295:134-143 PubMed29885354

2018

Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin promotes inflammation in mouse testes: The critical role of Klotho in Sertoli cells.

Applications

Species

Unspecified reactive species

Meihua Jin,Jing Lou,Huihui Yu,Miao Miao,Guangchuan Wang,Hao Ai,Yu Huang,Sangwon Han,Donghe Han,Guang Yu

Leukemia 31:602-613 PubMed27538486

2016

Inactivation of the putative ubiquitin-E3 ligase PDLIM2 in classical Hodgkin and anaplastic large cell lymphoma.

Applications

Species

Human

K D Wurster,F Hummel,J Richter,M Giefing,S Hartmann,M-L Hansmann,S Kreher,K Köchert,D Krappmann,W Klapper,M Hummel,S-S Wenzel,G Lenz,M Janz,B Dörken,R Siebert,S Mathas

Oncogene 33:1904-11 PubMed23584482

2013

PDLIM2 expression is driven by vitamin D and is involved in the pro-adhesion, and anti-migration and -invasion activity of vitamin D.

Applications

Unspecified application

Species

Human

E Vanoirbeek,G Eelen,L Verlinden,G Carmeliet,C Mathieu,R Bouillon,R O'Connor,G Xiao,A Verstuyf

View all publications

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Product promise

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For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-PDLIM2 antibody

Western blot - Anti-PDLIM2 antibody (AB68220)

Western blot - Anti-PDLIM2 antibody (AB68220)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

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Primary Antibodies

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