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AB198261

Anti-PDP1/PDP antibody

5

(2 Reviews)

|

(4 Publications)

Rabbit Polyclonal PDP1/PDP antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PDP1.

View Alternative Names

PDP, PPM2C, PDP1, PDP 1, Protein phosphatase 2C, Pyruvate dehydrogenase phosphatase catalytic subunit 1, PDPC 1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PDP1/PDP antibody (AB198261)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PDP1/PDP antibody (AB198261)

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling PDP1/PDP with ab198261 at 1/25 dilution.

Western blot - Anti-PDP1/PDP antibody (AB198261)
  • WB

Supplier Data

Western blot - Anti-PDP1/PDP antibody (AB198261)

Gel : 6% SDS-PAGE

All lanes:

Western blot - Anti-PDP1/PDP antibody (ab198261) at 1/300 dilution

All lanes:

Human bladder carcinoma tissue lysate at 40 µg

Predicted band size: 61 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human PDP1. The exact immunogen used to generate this antibody is proprietary information.

Q9P0J1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/25 - 1/100", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The pyruvate dehydrogenase phosphatase 1 (PDP1) is a mitochondrial enzyme that regulates the activity of the pyruvate dehydrogenase complex by dephosphorylating its E1 component. Also known as PDPc PDP1 has a molecular mass of approximately 56 kDa. Expression of PDP1 occurs in various tissues but shows higher levels in heart and skeletal muscles. These tissues demand efficient energy production correlating with PDP1's role in energy metabolism.
Biological function summary

PDP1 plays an essential role in converting pyruvate to acetyl-CoA a substrate for the Krebs cycle. PDP1 is part of the pyruvate dehydrogenase complex a multi-enzyme complex important for linking glycolysis to the citric acid cycle. This regulation ensures that cells can respond effectively to the energetic needs and environmental conditions optimizing production of ATP from glucose.

Pathways

PDP1 is involved in key metabolic pathways like the citric acid cycle and glucose metabolism. In glucose metabolism PDP1 interacts with pyruvate dehydrogenase kinase (PDK) as both enzymes control the phosphorylation state of the pyruvate dehydrogenase complex. This dynamic balance affects the availability of acetyl-CoA and thereby influences cellular respiration and energy production.

Malfunction of PDP1 associates with metabolic disorders such as pyruvate dehydrogenase deficiency and lactic acidosis. Mutations or dysregulations in PDP1 can disrupt acetyl-CoA production and lead to energy metabolism defects. The relationship between PDP1 and PDK also plays a role in understanding these conditions as both enzymes affect how well the cells manage energy impacting overall metabolic homeostasis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA.
See full target information PDP1
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

iScience 27:109075 PubMed38361607

2024

Sleep fragmentation induces heart failure in a hypertrophic cardiomyopathy mouse model by altering redox metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Karthikeyan Bose,Radhika Agrawal,Thiagarajan Sairam,Jessenya Mil,Matthew P Butler,Perundurai S Dhandapany

Scientific reports 10:17914 PubMed33087819

2020

TGF-β1 is a regulator of the pyruvate dehydrogenase complex in fibroblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Edward R Smith,Timothy D Hewitson

American journal of physiology. Regulatory, integr 317:R513-R520 PubMed31314546

2019

Increased pyruvate dehydrogenase activity in skeletal muscle of growth-restricted ovine fetuses.

Applications

Unspecified application

Species

Unspecified reactive species

Alexander L Pendleton,Laurel R Humphreys,Melissa A Davis,Leticia E Camacho,Miranda J Anderson,Sean W Limesand

Stem cell reviews and reports 15:427-438 PubMed30338499

2018

Metabolic Syndrome Modulates Protein Import into the Mitochondria of Porcine Mesenchymal Stem Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Arash Aghajani Nargesi,Xiang-Yang Zhu,LaTonya J Hickson,Sabena M Conley,Andre J van Wijnen,Lilach O Lerman,Alfonso Eirin
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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