AB228578

Anti-PDP1/PDP antibody

Name: Anti-PDP1/PDP antibody (ab228578) | Abcam
Brand: Abcam Limited
SKU: AB228578
Price: 525 USD
Availability: InStock

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(3 Publications)

Rabbit Polyclonal PDP1/PDP antibody. Suitable for WB and reacts with Mouse samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PDP1.

View Alternative Names

PDP, PPM2C, PDP1, PDP 1, Protein phosphatase 2C, Pyruvate dehydrogenase phosphatase catalytic subunit 1, PDPC 1

1 Images

Supplier Data

Western blot - Anti-PDP1/PDP antibody (AB228578)

10% SDS-PAGE

All lanes:

Western blot - Anti-PDP1/PDP antibody (ab228578) at 1/1000 dilution

All lanes:

Mouse testis tissue extracts at 50 µg

Predicted band size: 61 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

applications

Immunogen

Recombinant Fragment Protein within Human PDP1. The exact immunogen used to generate this antibody is proprietary information.

Q9P0J1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The pyruvate dehydrogenase phosphatase 1 (PDP1) is a mitochondrial enzyme that regulates the activity of the pyruvate dehydrogenase complex by dephosphorylating its E1 component. Also known as PDPc PDP1 has a molecular mass of approximately 56 kDa. Expression of PDP1 occurs in various tissues but shows higher levels in heart and skeletal muscles. These tissues demand efficient energy production correlating with PDP1's role in energy metabolism.

Biological function summary

PDP1 plays an essential role in converting pyruvate to acetyl-CoA a substrate for the Krebs cycle. PDP1 is part of the pyruvate dehydrogenase complex a multi-enzyme complex important for linking glycolysis to the citric acid cycle. This regulation ensures that cells can respond effectively to the energetic needs and environmental conditions optimizing production of ATP from glucose.

Pathways

PDP1 is involved in key metabolic pathways like the citric acid cycle and glucose metabolism. In glucose metabolism PDP1 interacts with pyruvate dehydrogenase kinase (PDK) as both enzymes control the phosphorylation state of the pyruvate dehydrogenase complex. This dynamic balance affects the availability of acetyl-CoA and thereby influences cellular respiration and energy production.

Malfunction of PDP1 associates with metabolic disorders such as pyruvate dehydrogenase deficiency and lactic acidosis. Mutations or dysregulations in PDP1 can disrupt acetyl-CoA production and lead to energy metabolism defects. The relationship between PDP1 and PDK also plays a role in understanding these conditions as both enzymes affect how well the cells manage energy impacting overall metabolic homeostasis.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA.

See full target information PDP1

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cell biochemistry and function 42:e3994 PubMed38566355

2024

PDP1 promotes the progression of breast cancer through STAT3 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yufeng Wang,Huifen Dang,Hui Qiao,Yinxia Tian,Quanlin Guan

Cell death discovery 8:347 PubMed35922422

2022

The mitochondrial RNA polymerase POLRMT promotes skin squamous cell carcinoma cell growth.

Applications

Unspecified application

Species

Unspecified reactive species

Yulong Wang,Li Ou,Xirong Li,Tingyu Zheng,Wei-Pei Zhu,Ping Li,Lijun Wu,Tianlan Zhao

Journal of clinical medicine 9: PubMed32276303

2020

Beneficial Effects of Acetyl-DL-Leucine (ADLL) in a Mouse Model of Sandhoff Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Ecem Kaya,David A Smith,Claire Smith,Barry Boland,Michael Strupp,Frances M Platt

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PDP1/PDP antibody

Western blot - Anti-PDP1/PDP antibody (AB228578)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

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