Anti-PDP2 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

PDP2 also known as pyruvate dehydrogenase phosphatase catalytic subunit 2 plays a critical role in energy metabolism. The protein dephosphorylates the pyruvate dehydrogenase (PDH) complex activating it to facilitate the conversion of pyruvate to acetyl-CoA an important step in cellular respiration. PDP2 has a molecular mass of approximately 61 kDa and is expressed in various tissues with higher expression noted in skeletal muscle and heart tissues. Through its enzymatic action PDP2 regulates the activity of the PDH complex and therefore influences the energy balance of cells.

Biological function summary

PDP2 contributes to energy homeostasis by modulating the activity of the PDH complex a major component in the mitochondrial matrix. It ensures the optimal function of the PDH complex which itself is a large multi-subunit structure comprising several enzymes including E1 E2 and E3 subunits. PDP2's dephosphorylation activity is central in facilitating the switch between glycolysis and oxidative phosphorylation allowing cells to adapt their energy production according to metabolic demands. This protein therefore plays a valuable role in the cellular metabolic network impacting ATP production efficiency.

Pathways

PDP2 is significant in the regulation of the tricarboxylic acid (TCA) cycle and glycolysis. It is inherently involved in the TCA cycle as it modulates the flux of acetyl-CoA into the cycle by regulating PDH complex activity. PDP2 also interacts with other proteins involved in the energy metabolism pathway such as PDH kinase isoenzymes which perform an antagonistic function by inactivating the PDH complex through phosphorylation. This regulatory balance ensures that cellular energy demands are met accurately and efficiently.

Associated diseases and disorders

Aberrations in PDP2 function have connections to metabolic disorders such as type 2 diabetes and heart failure. In type 2 diabetes impaired PDP2 activity can lead to reduced PDH complex activity contributing to altered glucose and lipid metabolism. Furthermore in heart failure inadequate PDP2 activity can disrupt energy production in cardiomyocytes exacerbating heart muscle dysfunction. Through these diseases PDP2 is linked with other metabolic proteins including insulin receptor substrates and mitochondrial dysfunction proteins illustrating its significance in both normal physiology and disease states.