AB131219

Anti-PDRG1 antibody [EPR6062(2)]

RabMAb
Recombinant
What is this?

(1 Review)

(2 Publications)

Rabbit Recombinant Monoclonal PDRG1 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.

View Alternative Names

C20orf126, PDRG, PDRG1, p53 and DNA damage-regulated protein 1

2 Images

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Western blot - Anti-PDRG1 antibody [EPR6062(2)] (AB131219)

All lanes:

Western blot - Anti-PDRG1 antibody [EPR6062(2)] (ab131219) at 1/1000 dilution

Lane 1:

293T cell lysate at 10 µg

Lane 2:

HeLa cell lysate at 10 µg

Lane 3:

Jurkat cell lysate at 10 µg

Lane 4:

MCF-7 cell lysate at 10 µg

Predicted band size: 15 kDa

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OI-RD Scanning - Anti-PDRG1 antibody [EPR6062(2)] (AB131219)

OI-RD Scanning

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OI-RD Scanning - Anti-PDRG1 antibody [EPR6062(2)] (AB131219)

We have systematically measured KD (the equilibrium dissociation constant between the antibody and its antigen), of more than 840 recombinant antibodies to assess not only their individual KD values but also to see the average affinity of antibody. Based on the comparison with published literature values for mouse monoclonal antibodies, Recombinant antibodies appear to be on average 1-2 order of magnitude higher affinity.

Carrier free

Anti-PDRG1 antibody [EPR6062(2)] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR6062(2)

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Stable for 12 months at -20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PDRG1 also known as p53 and DNA damage-regulated gene 1 is a protein with a mass of approximately 31 kilodaltons. It functions mechanically by influencing cell survival and proliferation processes. PDRG1 has a role in cellular response to stress with its expression prominently observed in testis tissues. Researchers have noted this protein's regulation under stress conditions indicating its involvement in maintaining cellular homeostasis.

Biological function summary

PDRG1 interacts with several proteins to carry out its functions potentially forming part of protein complexes influencing DNA repair mechanisms. It participates in cellular protection against genotoxic stress ensuring genome integrity. The protein's presence in testis suggests a role in germ cell development and the maintenance of reproductive health. This emphasizes its importance in the cellular systems governing DNA maintenance.

Pathways

PDRG1 plays a role in DNA damage response pathways specifically in the p53 signaling network. It interfaces with proteins such as p53 and those involved in apoptosis linking it to cellular death and survival pathways during stress. PDRG1's interaction with p53 suggests its close involvement in pathways that control cell cycle arrest and repair following DNA damage therefore participating in decision-making processes of cellular fate.

PDRG1 links to cancer development and progression through its modulation of the p53 network. Altered expression of PDRG1 associates with tumorigenesis particularly in testicular cancer where its dysregulation may disrupt normal cell cycle control. In relation to Alzheimer’s disease studies have suggested a potential involvement of PDRG1 with proteins like tau impacting neurodegenerative processes. Therefore PDRG1 plays a significant role in cellular dysfunctions seen in cancer and neurodegeneration.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

May play a role in chaperone-mediated protein folding.

See full target information PDRG1

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 14:4906 PubMed37582777

2023

mRNA 3'UTR lengthening by alternative polyadenylation attenuates inflammatory responses and correlates with virulence of Influenza A virus.

Applications

Unspecified application

Species

Unspecified reactive species

Valter Bergant,Daniel Schnepf,Niklas de Andrade Krätzig,Philipp Hubel,Christian Urban,Thomas Engleitner,Ronald Dijkman,Bernhard Ryffel,Katja Steiger,Percy A Knolle,Georg Kochs,Roland Rad,Peter Staeheli,Andreas Pichlmair

Pathology, research and practice 215:152567 PubMed31383535

2019

PDRG1 gene silencing contributes to inhibit the growth and induce apoptosis of gastric cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ya-Jing Zhang,Jing-Quan Li,Hua-Zhi Li,Hui Song,Chang-Sheng Wei,Shu-Qi Zhang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PDRG1 antibody [EPR6062(2)]

Western blot - Anti-PDRG1 antibody [EPR6062(2)] (AB131219)

OI-RD Scanning - Anti-PDRG1 antibody [EPR6062(2)] (AB131219)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

Product promise