AB47383

Anti-PDX1 antibody

Name: Anti-PDX1 antibody. Goat polyclonal (ab47383) | Abcam
Brand: Abcam Limited
SKU: AB47383
Price: 430 USD
Availability: InStock
Rating: 5 (5 reviews)

(5 Reviews)

(74 Publications)

Goat Polyclonal PDX1 antibody. Suitable for ELISA and reacts with Mouse, Human samples. Cited in 74 publications.

View Alternative Names

IPF1, STF1, PDX1, Pancreas/duodenum homeobox protein 1, PDX-1, Glucose-sensitive factor, Insulin promoter factor 1, Insulin upstream factor 1, Islet/duodenum homeobox-1, Somatostatin-transactivating factor 1, GSF, IPF-1, IUF-1, IDX-1, STF-1

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

ELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Properties and storage information

Form

Liquid

Purity

Whole antiserum

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Pancreatic duodenal homeobox 1 (PDX1) also known as insulin promoter factor 1 (IPF1) is an important transcription factor with a molecular weight of approximately 31 kDa. PDX1 plays an essential role in the development and function of the pancreas. This protein is mainly expressed in the pancreatic beta cells where it regulates gene expression linked to insulin production. Its expression also extends to the duodenum where it influences other developmental processes.

Biological function summary

PDX1 plays a critical role in pancreatic development beta-cell differentiation and insulin gene transcription. It functions as part of a protein complex that controls key aspects of beta-cell identity and function. The interactions within this complex allow PDX1 to effectively modulate pancreatic gene expression and maintain glucose homeostasis.

Pathways

PDX1 is deeply involved in the insulin secretion pathway and the regulation of glucose metabolism. It interacts with other transcription factors such as MAFA and NEUROD1 to carry out its role in these pathways. The presence of PDX1 in these pathways ensures the proper regulation of genes essential for insulin production and release connecting it to various metabolic processes.

PDX1 associates mainly with diabetes mellitus and pancreatic agenesis. Mutations or functional impairments in PDX1 affect insulin production leading to diabetes. Furthermore in pancreatic agenesis where the pancreas fails to develop PDX1 malfunctions are often implicated. PDX1 interactions with proteins like MAFA and NEUROD1 during this process are critical; alterations in these relationships can exacerbate disease states linking PDX1 to both genetic and acquired forms of pancreatic dysfunction.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1 : PBX1b : MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

See full target information PDX1

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Publications (74)

Recent publications for all applications. Explore the full list and refine your search

Nature metabolism 7:1570-1592 PubMed40691304

2025

LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes.

Applications

Unspecified application

Species

Unspecified reactive species

Jin Li,Yamei Deng,Marie Gasser,Jie Zhu,Emily M Walker,Vaibhav Sidarala,Emma C Reck,Dre L Hubers,Mabelle B Pasmooij,Chun-Shik Shin,Khushdeep Bandesh,Eftyhmios Motakis,Siddhi Nargund,Romy Kursawe,Venkatesha Basrur,Alexey I Nesvizhskii,Michael L Stitzel,David C Chan,Guy A Rutter,Scott A Soleimanpour

Nature communications 16:4697 PubMed40393969

2025

ACSS2 mediates an epigenetic pathway to regulate β-cell adaptation during gestation in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Zhang,Shuang He,Xi Wang,Xin Wang,Mao-Yang He,Xin-Xin Yu,Cheng-Ran Xu

Oncology letters 29:288 PubMed40264825

2025

Prognostic value of protein expression, tumor morphology and location within the pancreas in pancreatic ductal adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Haruto Nishida,Kengo Ando,Ryo Kaimori,Kazuhiro Kawamura,Tsutomu Daa

Frontiers in cell and developmental biology 12:1490040 PubMed39493348

2024

A differentiation protocol for generating pancreatic delta cells from human pluripotent stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Tongran Zhang,Nannan Wang,Zhiying Liao,Jingyi Chen,Hao Meng,Haopeng Lin,Tao Xu,Lihua Chen,Ling-Qiang Zhu,Huisheng Liu

Nature communications 15:3740 PubMed38702347

2024

Acinar to β-like cell conversion through inhibition of focal adhesion kinase.

Applications

Unspecified application

Species

Unspecified reactive species

Shakti Dahiya,Mohamed Saleh,Uylissa A Rodriguez,Dhivyaa Rajasundaram,Jorge R Arbujas,Arian Hajihassani,Kaiyuan Yang,Anuradha Sehrawat,Ranjeet Kalsi,Shiho Yoshida,Krishna Prasadan,Heiko Lickert,Jing Hu,Jon D Piganelli,George K Gittes,Farzad Esni

Cell calcium 120:102884 PubMed38574509

2024

PDX1, a transcription factor essential for organ differentiation, regulates SERCA-dependent Ca homeostasis in sensory neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Jami L Saloman,Ariel Y Epouhe,Catherine F Ruff,Kathryn M Albers

Islets 15:2267725 PubMed37838950

2023

Dynamic regulation of pancreatic β cell function and gene expression by the SND1 coregulator .

Applications

Unspecified application

Species

Unspecified reactive species

Sukrati Kanojia,Rebecca K Davidson,Jason M Conley,Jerry Xu,Meredith Osmulski,Emily K Sims,Hongxia Ren,Jason M Spaeth

Diabetes 72:1609-1620 PubMed37625131

2023

Establishment of Pancreatic β-Cell-Specific Gene Knockout System Based on CRISPR-Cas9 Technology With AAV8-Mediated gRNA Delivery.

Applications

Unspecified application

Species

Unspecified reactive species

Kyosei Ueki,Yuya Nishida,Shuhei Aoyama,Hirotsugu Uzawa,Akiko Kanai,Minami Ito,Koki Ikeda,Hitoshi Iida,Takeshi Miyatsuka,Hirotaka Watada

Development (Cambridge, England) 150: PubMed36897571

2023

MafB-dependent neurotransmitter signaling promotes β cell migration in the developing pancreas.

Applications

Unspecified application

Species

Unspecified reactive species

Sara Bsharat,Emanuela Monni,Tania Singh,Jenny K Johansson,Kavya Achanta,Ludivine Bertonnier-Brouty,Anja Schmidt-Christensen,Dan Holmberg,Zaal Kokaia,Rashmi B Prasad,Isabella Artner

Cells, tissues, organs 213:223-234 PubMed36380637

2022

Protocol-Dependent Morphological Changes in Human Embryonic Stem Cell Aggregates during Differentiation toward Early Pancreatic Fate.

Applications

Unspecified application

Species

Unspecified reactive species

Elmira Rezaei Zonooz,Zahra Ghezelayagh,Azadeh Moradmand,Hossein Baharvand,Yaser Tahamtani

View all publications

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