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AB121210

Anti-PDZD11 antibody

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(3 Publications)

Rabbit Polyclonal PDZD11 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PDZD11 aa 1-150.

View Alternative Names

AIPP1, PDZK11, PISP, HSPC227, UNQ6486/PRO21335, PDZD11, PDZ domain-containing protein 11, ATPase-interacting PDZ protein, Plasma membrane calcium ATPase-interacting single-PDZ protein, PMCA-interacting single-PDZ protein

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PDZD11 antibody (AB121210)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PDZD11 antibody (AB121210)

ab121210 at 1/10 dilution staining PDZD11 in Paraffin-embedded Human duodenum tissue by Immunohistochemistry.

Western blot - Anti-PDZD11 antibody (AB121210)
  • WB

Unknown

Western blot - Anti-PDZD11 antibody (AB121210)

All lanes:

Western blot - Anti-PDZD11 antibody (ab121210) at 1/250 dilution

Lane 2:

Negative control (vector only transfected HEK293T lysate)

Lane 3:

Over expression Lysate (Coexpressed with a C terminal myc DDK tag (~3.1 kDa) in mammalian HEK293T cells

Predicted band size: 16 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PDZD11 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q5EBL8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/10 - 1/20", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PDZD11 also known as PDZ domain containing 11 is a small protein with a mass of approximately 16 kDa. It contains a PDZ domain which allows for interaction with other proteins. This protein expresses in various tissues with notable levels in the brain heart and skeletal muscle. Mechanically PDZD11 interacts with other PDZ domain-containing proteins aiding in scaffolding functions that are important for many cellular processes.
Biological function summary

PDZD11 plays a role in organizing protein complexes at the plasma membrane which are important for signaling pathways. It is part of the protein complex involved in cellular signaling and communication. The scaffolding ability can influence interactions and maintenance of cellular function by anchoring essential signaling molecules which includes proteins involved in maintaining synaptic structures in neurons.

Pathways

Studies show the involvement of PDZD11 in the regulation of the MAPK signaling pathway and the organization of cytoskeletal components. It plays a part by interacting with other proteins in the pathway such as kinases and phosphatases facilitating proper signal transduction and cellular response to stimuli. Within the MAPK signaling pathway it contributes by helping regulate cellular activities like gene expression and cell division which are essential for cell growth and differentiation.

PDZD11 has shown connections to neurological disorders and muscle pathologies. For instance variants affecting PDZD11 function might contribute to cognitive disorders due to its role in synaptic maintenance and also muscle diseases because of its expression in skeletal muscle tissues. The interactions with proteins involved in these conditions may reveal therapeutic targets providing new directions for treatments focusing on overcoming or compensating dysfunctional protein interactions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10-binding protein TSPAN33.
See full target information PDZD11
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cancer medicine 12:15289-15303 PubMed37260179

2023

The role of DYNLT3 in breast cancer proliferation, migration, and invasion via epithelial-to-mesenchymal transition.

Applications

Unspecified application

Species

Unspecified reactive species

Han Wang,Xin Chen,Yanshan Jin,Tingxian Liu,Yizuo Song,Xuejie Zhu,Xueqiong Zhu

Frontiers in cell and developmental biology 10:1075810 PubMed36589750

2022

Screening and diagnosis of triple negative breast cancer based on rapid metabolic fingerprinting by conductive polymer spray ionization mass spectrometry and machine learning.

Applications

Unspecified application

Species

Unspecified reactive species

Yaoyao Song,Yan Zhang,Songhai Xie,Xiaowei Song

Frontiers in genetics 12:669928 PubMed34093661

2021

Elevated Expression of PDZD11 Is Associated With Poor Prognosis and Immune Infiltrates in Hepatocellular Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yao Chen,Haifeng Xie,Ting Xie,Xunjun Yang,Yilin Pang,SongDao Ye
View all publications
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Product promise

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