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AB272628

Anti-PDZRN3 antibody

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Rabbit Polyclonal PDZRN3 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PDZRN3 aa 750-900.

View Alternative Names

KIAA1095, LNX3, SEMCAP3, PDZRN3, E3 ubiquitin-protein ligase PDZRN3, Ligand of Numb protein X 3, PDZ domain-containing RING finger protein 3, RING-type E3 ubiquitin transferase PDZRN3, Semaphorin cytoplasmic domain-associated protein 3, Protein SEMACAP3

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PDZRN3 antibody (AB272628)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PDZRN3 antibody (AB272628)

Paraffin-embedded formalin-fixed Human duodenum tissue stained for PDZRN3 using ab272628 at 1/200 in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-PDZRN3 antibody (AB272628)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-PDZRN3 antibody (AB272628)

PFA fixed, Triton X-100 permeablized human cell line U-2 OS labeling PDZRN3 (green) using ab272628 at 2 ug/ml in ICC/IF analysis.

Western blot - Anti-PDZRN3 antibody (AB272628)
  • WB

Unknown

Western blot - Anti-PDZRN3 antibody (AB272628)

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Western blot - Anti-PDZRN3 antibody (ab272628)

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Western blot - Anti-PDZRN3 antibody (ab272628) at 0.4 µg/mL

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Molecular weight ladder

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RT4

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U-251MG sp

Predicted band size: 120 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human PDZRN3 aa 750-900. The exact immunogen used to generate this antibody is proprietary information.

Q9UPQ7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PDZRN3 also known as LNX3 or SEMCAP3 is a protein with significant involvement in cellular and signaling processes. As a member of the LNX family of proteins PDZRN3 features PDZ domains RING finger motifs and a mass of around 90 kDa. This protein is expressed throughout various tissues including the heart and skeletal muscle. Its structure allows it to interact with proteins containing PDZ-binding motifs offering versatility in its mechanical role within the cell.
Biological function summary

PDZRN3 plays a role in modulating cellular signaling pathways and is significant in developmental processes such as myogenesis and osteogenesis. It can form protein complexes through its PDZ domains enabling it to serve as a scaffold for partner proteins. PDZRN3's influence in cellular differentiation highlights its importance in tissue development and structural integrity.

Pathways

PDZRN3 acts within pathways associated with the Wnt signaling and Hippo pathways. These pathways involve key proteins that control cell proliferation and apoptosis. PDZRN3 interacts with proteins such as Dishevelled in the Wnt signaling pathway and supports the regulation of cell fate and growth. Through these interactions PDZRN3 influences pivotal decisions within cellular processes that maintain homeostasis and facilitate development.

PDZRN3 has correlations with cancer and cardiovascular diseases. Aberrant expression of PDZRN3 can affect cell growth and differentiation contributing to tumorigenesis and the progression of certain cancer types. In cardiovascular contexts imbalances in PDZRN3 expression may disrupt signaling pathways that ensure normal heart function. By interacting with proteins linked to these diseases PDZRN3 emerges as a therapeutic target of interest for further research and intervention strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation.
See full target information PDZRN3
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Product promise

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