PE Anti-Bovine MHC Class II DQ antibody [CC158]

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

MHC Class II DQ molecules in cattle anchor the immune defense against extracellular pathogens. They form a heterodimer consisting of an alpha and a beta chain which is essential for its antigen-presenting function. The heterodimer binds processed peptide fragments derived from pathogens displaying them on the cell surface to T-helper cells. By doing so they enable the recognition and initiation of specific immune responses which is a pivotal step in adaptive immunity.

Pathways

The MHC Class II DQ molecules are active participants in the antigen processing and presentation pathway. This pathway is essential in facilitating communication between the innate and adaptive immune systems. The presentation of antigens through MHC Class II is closely associated with the T-cell receptor signaling pathway. Proteins such as CD4 and the T-cell receptor are directly involved in recognizing and binding to the antigen-MHC complex on antigen-presenting cells. These interactions trigger downstream signaling cascades leading to T-cell activation and differentiation.