AB95662

PE Anti-CCR5 antibody [HM-CCR5(7A4)]

Name: Anti-CCR5 PE antibody [HM-CCR5(7A4)] (ab95662) IgG | Abcam
Brand: Abcam Limited
SKU: AB95662
Price: 200 USD
Availability: InStock

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(1 Publication)

Armenian hamster Monoclonal CCR5 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Full Length Protein corresponding to Mouse Ccr5.

View Alternative Names

CD195, Cmkbr5, C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, MIP-1 alpha receptor

1 Images

Flow Cytometry - PE Anti-CCR5 antibody [HM-CCR5(7A4)] (AB95662)

Flow Cyt

Unknown

Flow Cytometry - PE Anti-CCR5 antibody [HM-CCR5(7A4)] (AB95662)

Flow cytometry images showing staining of FcR-blocked (Anti-Mouse CD16/CD32) BALB/c thioglycolate-induced peritoneal exudate cells with Anti-Mouse CD11b FITC and 0.5 µg of Armenian Hamster IgG Isotype Control PE (left) or 0.5 µg of ab95662 (right). Total viable cells were used for analysis.

Key facts

Host species

Armenian hamster

Clonality

Monoclonal

Clone number

HM-CCR5(7A4)

Isotype

IgG

Conjugation

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Carrier free

Reacts with

Mouse

Applications

Flow Cyt

applications

Immunogen

Full Length Protein corresponding to Mouse Ccr5. The exact immunogen used to generate this antibody is proprietary information.

P51682

Specificity

Binds to the N terminal extracellular domain of Mouse CCR5 with no cross reactivity to Human CCR5.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "0.5-1 µg for 10^5-10^8 Cells", "FlowCyt-species-notes": "in a final volume of 100 μL.ab101026 - Armenian Hamster monoclonal IgG, is suitable for use as an isotype control with this antibody." }, "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "0.5-1 µg for 10^5-10^8 Cells", "FlowCyt-species-notes": "in a final volume of 100 μL.ab101026 - Armenian Hamster monoclonal IgG, is suitable for use as an isotype control with this antibody." } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Storage buffer

pH: 7.2 Preservative: 0.09% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CCR5 also known as the C-C chemokine receptor type 5 is a protein that functions as a receptor on the surface of cells predominantly immune cells like T-cells macrophages and dendritic cells. The approximate molecular weight of CCR5 is 40 kDa. This protein belongs to the G-protein-coupled receptor family and it mainly binds to β-chemokines. CCR5 is abundantly expressed in immune tissues such as the spleen thymus and lymph nodes. Researchers often use assays like the CCR5 ELISA kit to detect or quantify its presence in various samples.

Biological function summary

CCR5 acts as a receptor for various chemokines specifically CCL3 CCL4 and CCL5 which are involved in leukocyte trafficking and immune response modulation. It plays an important role in the migration of immune cells to sites of inflammation or injury. This protein does not function in isolation; it sometimes forms part of larger complexes with other cell surface proteins to mediate responses to external signals. For example anti-CCR5 antibodies like 12D1 can modulate its activity and influence immune cell behavior.

Pathways

CCR5 is intricately involved in chemokine signaling pathways and inflammatory response pathways. Through these pathways it interacts with proteins such as CXCR4 and CCR1. CCR5 and CXCR4 another chemokine receptor are well-documented for their role in HIV entry into host cells. These pathways are critical for orchestrating immune cell movement and activating signaling cascades that promote immune defense mechanisms.

CCR5 has a significant association with HIV infection and is a known co-receptor facilitating the virus's entry into immune cells. The presence of mutations like the Δ32 allele in the CCR5 gene provides resistance against HIV infection highlighting its importance in disease dynamics. CCR5 also plays a role in inflammatory diseases such as rheumatoid arthritis where it contributes to the migration of immune cells into joints exacerbating inflammation. In these contexts CCR5 interacts with other inflammatory mediators offering potential therapeutic targets for drug development.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.

See full target information Ccr5

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 15:1410564 PubMed39007148

2024

Non-viral-mediated gene transfer of OX40 ligand for tumor immunotherapy.

Applications

Unspecified application

Species

Unspecified reactive species

Olga A Rakitina,Alexey I Kuzmich,Olga A Bezborodova,Sofia A Kondratieva,Victor V Pleshkan,Marina V Zinovyeva,Dmitry A Didych,Aleksandr V Sass,Eugene V Snezhkov,Maria B Kostina,Maksim O Koksharov,Irina V Alekseenko

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

PE Anti-CCR5 antibody [HM-CCR5(7A4)]

Flow Cytometry - PE Anti-CCR5 antibody [HM-CCR5(7A4)] (AB95662)

Key facts

Host species

Clonality

Clone number

Isotype

Conjugation

Excitation/Emission

Carrier free

Reacts with

Applications

Immunogen

Specificity

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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