AB53321

PE Anti-CD105 antibody [MEM-229]

Name: Anti-CD105 PE antibody [MEM-229] (ab53321) Mouse monoclonal IgG2a | Abcam
Brand: Abcam Limited
SKU: AB53321
Price: 270 USD
Availability: InStock

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(28 Publications)

Mouse Monoclonal CD105 antibody - conjugated to PE. Suitable for IHC-Fr and reacts with Pig samples. Cited in 28 publications. Immunogen corresponding to Recombinant Virus within Human ENG.

View Alternative Names

CD105, END, ENG, Endoglin

1 Images

Immunohistochemistry (Frozen sections) - PE Anti-CD105 antibody [MEM-229] (AB53321)

IHC-Fr

Unknown

Immunohistochemistry (Frozen sections) - PE Anti-CD105 antibody [MEM-229] (AB53321)

ab53318 staining CD105 in infarcted porcine heart by Immunohistochemistry (Frozen sections). Cell nuclei were counterstained blue with DAPI.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

MEM-229

Isotype

IgG2a

Conjugation

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Carrier free

Reacts with

Pig

Applications

IHC-Fr

applications

Immunogen

Recombinant Virus within Human ENG. The exact immunogen used to generate this antibody is proprietary information.

P17813

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Pig": { "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "1/200", "IHCFr-species-notes": "<p>Fix with acetone.</p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Size-exclusion chromatography

Storage buffer

pH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS, 0.2% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD105 also known as endoglin or the CD105 marker is a transmembrane glycoprotein with a molecular weight of approximately 180 kDa. It is a component of the TGF-beta receptor complex and exists in endothelial cells where it is abundantly expressed. Expression of CD105 is higher in proliferating cells particularly in the vasculature. You can also find it in tissues involved in the formation and remodeling of blood vessels such as during angiogenesis.

Biological function summary

Endoglin functions in the regulation of angiogenesis and vascular remodeling. It plays a significant role in mediating cellular responses to TGF-beta signaling influencing endothelial cell proliferation and migration. While not part of a larger structural complex endoglin interacts with receptors and signaling molecules important for vascular development and repair processes. This involvement aids in maintaining endothelial integrity and function under various physiological conditions.

Pathways

CD105 participates in the TGF-beta signaling and angiogenesis pathways. In these pathways it acts in conjunction with other proteins like TGF-beta receptors which play roles in cell differentiation proliferation and apoptosis. The interaction between CD105 and TGF-beta signaling regulates numerous cellular mechanisms impacting angiogenesis and cellular responses to environmental changes.

CD105 has links to hereditary hemorrhagic telangiectasia (HHT) and certain cancers. In HHT mutations in the endoglin gene alter vascular structure leading to the formation of abnormal blood vessels. Oncologically overexpression of CD105 is present in tumor angiogenesis aiding in the progression of certain cancers. Other proteins like VEGF and TGF-beta closely interact with endoglin influencing disease progression and presenting potential targets for therapeutic intervention.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed : 21737454, PubMed : 23300529). Required for normal structure and integrity of adult vasculature (PubMed : 7894484). Regulates the migration of vascular endothelial cells (PubMed : 17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed : 1692830). Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed : 21737454, PubMed : 22347366, PubMed : 23300529, PubMed : 8370410). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed : 21737454, PubMed : 22347366, PubMed : 23300529).

See full target information ENG

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Publications (28)

Recent publications for all applications. Explore the full list and refine your search

Cells 14: PubMed40940806

2025

Development and Characterization of a Novel Lineage of Renal Progenitor Cells for Potential Use in Feline Chronic Kidney Disease: A Preliminary Study.

Applications

Unspecified application

Species

Unspecified reactive species

Lara Carolina Mario,Juliana de Paula Nhanharelli,Jéssica Borghesi,Rafaela Rodrigues Ribeiro,Hianka Jasmyne Costa de Carvalho,Thamires Santos da Silva,Mariano Del Sol,Rodrigo da Silva Nunes Barreto,Sandra Maria Barbalho,Maria Angelica Miglino

Stem cell research & therapy 15:434 PubMed39551765

2024

Prolonged cultivation enhances the stimulatory activity of hiPSC mesenchymal progenitor-derived conditioned medium.

Applications

Unspecified application

Species

Unspecified reactive species

Darja Marolt Presen,Vanessa Goeschl,Dominik Hanetseder,Laura Ogrin,Alexandra-Larissa Stetco,Anja Tansek,Laura Pozenel,Bella Bruszel,Goran Mitulovic,Johannes Oesterreicher,Johannes Zipperle,Barbara Schaedl,Wolfgang Holnthoner,Johannes Grillari,Heinz Redl

Stem cell research & therapy 15:162 PubMed38853239

2024

The impact of hypoxia preconditioning on mesenchymal stem cells performance in hypertensive kidney disease.

Applications

Unspecified application

Species

Unspecified reactive species

Gurparneet Kaur Sohi,Naba Farooqui,Arjunmohan Mohan,Kamalnath Sankaran Rajagopalan,Li Xing,Xiang Y Zhu,Kyra Jordan,James D Krier,Ishran M Saadiq,Hui Tang,LaTonya J Hickson,Alfonso Eirin,Lilach O Lerman,Sandra M Herrmann

Journal of the American Heart Association 13:e029880 PubMed38639336

2024

Alginate-Encapsulated Mesenchymal Stromal Cells Improve Hind Limb Ischemia in a Translational Swine Model.

Applications

Unspecified application

Species

Unspecified reactive species

Juline N Deppen,Sydney C Ginn,Erica O Tang,Lanfang Wang,Maegan L Brockman,Rebecca D Levit

Stem cell research & therapy 14:49 PubMed36949528

2023

Diabetic kidney disease induces transcriptome alterations associated with angiogenesis activity in human mesenchymal stromal cells.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaohui Bian,Sabena M Conley,Alfonso Eirin,Eric A Zimmerman Zuckerman,Anastasia L Smith,Cody C Gowan,Zachary K Snow,Tambi Jarmi,Houssam Farres,Young M Erben,Albert G Hakaim,Matthew A Dietz,Abba C Zubair,Saranya P Wyles,Joy V Wolfram,Lilach O Lerman,LaTonya J Hickson

Stem cell reviews and reports 19:491-502 PubMed36048327

2022

Efficacy of Human Embryonic Stem Cells Compared to Adipose Tissue-Derived Human Mesenchymal Stem/Stromal Cells for Repair of Murine Post-Stenotic Kidneys.

Applications

Unspecified application

Species

Unspecified reactive species

Sarosh Siddiqi,Nattawat Klomjit,Kai Jiang,Sabena M Conley,Xianyang Zhu,Ishran M Saadiq,Christopher M Ferguson,Hui Tang,Amir Lerman,Lilach O Lerman

Developmental cell 57:914-929.e7 PubMed35320732

2022

Cellular heterogeneity of human fallopian tubes in normal and hydrosalpinx disease states identified using scRNA-seq.

Applications

Unspecified application

Species

Unspecified reactive species

Nicole D Ulrich,Yu-Chi Shen,Qianyi Ma,Kun Yang,D Ford Hannum,Andrea Jones,Jordan Machlin,John F Randolph,Yolanda R Smith,Samantha B Schon,Ariella Shikanov,Erica E Marsh,Richard Lieberman,Stephen J Gurczynski,Bethany B Moore,Jun Z Li,Sue Hammoud

International journal of molecular sciences 23: PubMed35328732

2022

Vascular Remodeling of Clinically Used Patches and Decellularized Pericardial Matrices Recellularized with Autologous or Allogeneic Cells in a Porcine Carotid Artery Model.

Applications

Unspecified application

Species

Unspecified reactive species

Jaroslav Chlupac,Roman Matejka,Miroslav Konarik,Robert Novotny,Zuzana Simunkova,Iveta Mrazova,Ondrej Fabian,Milan Zapletal,Zdenek Pulda,Jan Falk Lipensky,Jana Stepanovska,Karel Hanzalek,Antonin Broz,Tomas Novak,Alena Lodererova,Ludek Voska,Theodor Adla,Jiri Fronek,Miroslav Rozkot,Serhiy Forostyak,Peter Kneppo,Lucie Bacakova,Jan Pirk

In vivo (Athens, Greece) 35:2127-2134 PubMed34182488

2021

Integrin α5β1 Mediated Cellular Reorganization in Human Mesenchymal Stem Cells During Neuronal Differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Nihal Karakaş,Ülkan Kiliç

International journal of molecular sciences 22: PubMed34073117

2021

Human-Induced Neural and Mesenchymal Stem Cell Therapy Combined with a Curcumin Nanoconjugate as a Spinal Cord Injury Treatment.

Applications

Unspecified application

Species

Unspecified reactive species

Pablo Bonilla,Joaquim Hernandez,Esther Giraldo,Miguel A González-Pérez,Ana Alastrue-Agudo,Hoda Elkhenany,María J Vicent,Xavier Navarro,Michael Edel,Victoria Moreno-Manzano

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

PE Anti-CD105 antibody [MEM-229]

Immunohistochemistry (Frozen sections) - PE Anti-CD105 antibody [MEM-229] (AB53321)

Key facts

Host species

Clonality

Clone number

Isotype

Conjugation

Excitation/Emission

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (28)

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