Rat Monoclonal CD105 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 7 publications. Immunogen corresponding to Tissue preparation containing Eng protein.
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![Flow Cytometry - PE Anti-CD105 antibody [MJ7/18] (AB93567), expandable thumbnail](https://content.abcam.com/products/images/pe-cd105-antibody-mj7-18-ab93567--flow-cytometry-img41930.gif "Flow Cytometry - PE Anti-CD105 antibody [MJ7/18] (AB93567)")
Publications
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- Nature communications 8:160742017Non-canonical NOTCH3 signalling limits tumour angiogenesis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShuheng Lin et. al.PubMed 28719575
- Stem cells international 2014:5763582014Osteogenic Potential of Mouse Adipose-Derived Stem Cells Sorted for CD90 and CD105 In Vitro.
- PloS one 8:e753832013Amniotic fluid stem cells from EGFP transgenic mice attenuate hyperoxia-induced acute lung injury.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShih-Tao Wen et. al.PubMed 24040409
- Cancer research 67:10268-772007A role for endoglin as a suppressor of malignancy during mouse skin carcinogenesis.Applications:WBReactive species:Unspecified reactive speciesEduardo Pérez-Gómez,María Villa-Morales,Javier Santos,José Fernández-Piqueras,Carlos Gamallo,Javier Dotor,Carmelo Bernabéu,Miguel QuintanillaPubMed 17974968
- Clinical cancer research : an official journal of the American Association for Cancer Research 13:323-302007Monitoring response to anticancer therapy by targeting microbubbles to tumor vasculature.Applications:IHC-FrReactive species:Unspecified reactive speciesGrzegorz Korpanty,Juliet G Carbon,Paul A Grayburn,Jason B Fleming,Rolf A BrekkenPubMed 17200371
- Journal of immunology (Baltimore, Md. : 1950) 175:139-462005Liver sinusoidal endothelial cells tolerize T cells across MHC barriers in mice.Applications:IHC-FrReactive species:Unspecified reactive speciesTakashi Onoe,Hideki Ohdan,Daisuke Tokita,Masayuki Shishida,Yuka Tanaka,Hidetaka Hara,Wendy Zhou,Kohei Ishiyama,Hiroshi Mitsuta,Kentaro Ide,Toshimasa AsaharaPubMed 15972640
- Oncogene 22:5976-852003Expression of the TGF-beta coreceptor endoglin in epidermal keratinocytes and its dual role in multistage mouse skin carcinogenesis.Applications:IHC-Fr, WBReactive species:Unspecified reactive speciesMiguel Quintanilla,Jose Ramón Ramirez,Eduardo Pérez-Gómez,Diana Romero,Beatriz Velasco,Michelle Letarte,Jose Miguel López-Novoa,Carmelo BernabéuPubMed 12955076
Key facts
- Isotype
- IgG2a
- Host species
- Rat
- Conjugation
- PE
- Excitation/Emission
- Ex: 480;565nm, Em: 578nm
- Storage buffer
pH: 7.2
Preservative: 0.09% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- Tissue preparation containing Eng protein. The exact immunogen used to generate this antibody is proprietary information. Database link Q63961
Reactivity data
Select an application| Flow Cyt | |
|---|---|
| Mouse | Tested |
Flow Cyt
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 0.25000-0.50000 µg for 105-108 Cells | Notes ab134674 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
Associated Products
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7 products for Alternative Product
2 products for Alternative Version
Target data
Function
Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:10625534). Required for normal structure and integrity of adult vasculature (By similarity). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (PubMed:10625534). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (PubMed:28530658). May play a role in the binding of endothelial cells to integrins. Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (By similarity).
Alternative names
CD105, Edg, Eng, Endoglin, Cell surface MJ7/18 antigen
Recommended products
Rat Monoclonal CD105 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 7 publications. Immunogen corresponding to Tissue preparation containing Eng protein.
Key facts
- Isotype
- IgG2a
- Host species
- Rat
- Conjugation
- PE
- Excitation/Emission
- Ex: 480;565nm, Em: 578nm
- Storage buffer
pH: 7.2
Preservative: 0.09% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- Tissue preparation containing Eng protein. The exact immunogen used to generate this antibody is proprietary information. Database link Q63961
- Clone number
- MJ7/18
- Purification technique
- Affinity purification Protein G
- Light chain type
- kappa
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CD105 also known as endoglin or the CD105 marker is a transmembrane glycoprotein with a molecular weight of approximately 180 kDa. It is a component of the TGF-beta receptor complex and exists in endothelial cells where it is abundantly expressed. Expression of CD105 is higher in proliferating cells particularly in the vasculature. You can also find it in tissues involved in the formation and remodeling of blood vessels such as during angiogenesis.
- Biological function summary
Endoglin functions in the regulation of angiogenesis and vascular remodeling. It plays a significant role in mediating cellular responses to TGF-beta signaling influencing endothelial cell proliferation and migration. While not part of a larger structural complex endoglin interacts with receptors and signaling molecules important for vascular development and repair processes. This involvement aids in maintaining endothelial integrity and function under various physiological conditions.
- Pathways
CD105 participates in the TGF-beta signaling and angiogenesis pathways. In these pathways it acts in conjunction with other proteins like TGF-beta receptors which play roles in cell differentiation proliferation and apoptosis. The interaction between CD105 and TGF-beta signaling regulates numerous cellular mechanisms impacting angiogenesis and cellular responses to environmental changes.
- Associated diseases and disorders
CD105 has links to hereditary hemorrhagic telangiectasia (HHT) and certain cancers. In HHT mutations in the endoglin gene alter vascular structure leading to the formation of abnormal blood vessels. Oncologically overexpression of CD105 is present in tumor angiogenesis aiding in the progression of certain cancers. Other proteins like VEGF and TGF-beta closely interact with endoglin influencing disease progression and presenting potential targets for therapeutic intervention.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Flow Cytometry - PE Anti-CD105 antibody [MJ7/18] (ab93567)
Staining of bEnd.3 (Mouse brain endothelioma cell line) whole cell lysate with 0.25 μg of PE Rat IgG2a Isotype Control (open histogram) or 0.25 μg of ab93567 (colored histogram). Total viable cells were used for analysis.
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