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AB275953

PE Anti-CD109 antibody [W7C5]

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Mouse Monoclonal CD109 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples. Immunogen corresponding to Cell preparation containing CD109 protein.

View Alternative Names

CD109, CPAMD7, CD109 antigen, 150 kDa TGF-beta-1-binding protein, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7, Platelet-specific Gov antigen, p180, r150

2 Images
Flow Cytometry - PE Anti-CD109 antibody [W7C5] (AB275953)
  • Flow Cyt

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Flow Cytometry - PE Anti-CD109 antibody [W7C5] (AB275953)

Separation of human CD109 positive cells (red-filled) from CD109 negative cells (black-dashed) in flow cytometry analysis (surface staining) of human PHA stimulated peripheral blood mononuclear cells stained using ab275953 (10 μl reagent per milion cells in 100 μl of cell suspension).

Flow Cytometry - PE Anti-CD109 antibody [W7C5] (AB275953)
  • Flow Cyt

Unknown

Flow Cytometry - PE Anti-CD109 antibody [W7C5] (AB275953)

Flow cytometry surface staining pattern of human PHA stimulated peripheral blood mononuclear cells stained using ab275953 (10 μl reagent per milion cells in 100 μl of cell suspension).

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

W7C5

Isotype

IgG1

Conjugation

PE

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing CD109 protein. The exact immunogen used to generate this antibody is proprietary information.

Q6YHK3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>10 μl reagent / 100 μl of whole blood or 10<sup>6</sup> cells in a suspension.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Size-exclusion chromatography
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Do Not Freeze|Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD109 also known as platelet activation antigen 3 is a glycoprotein with a molecular weight around 170 kDa. You can find it mostly expressed on the surface of platelets activated T-cells epithelial cells and some tumor cells. This protein belongs to the α2-macroglobulin/C3 C4 C5 family and plays a part in regulating several cellular activities. CD109 acts mechanically as a glycosylphosphatidylinositol (GPI)-anchored protein which suggests its involvement in signal transduction processes.
Biological function summary

The protein CD109 modulates several cellular functions including cell proliferation differentiation and immune response regulation. The protein works as a negative regulator of TGF-β signaling by forming a complex with the TGF-β receptor. This activity influences processes like wound healing and immune regulation where TGF-β plays a vital role. CD109 expression also impacts cellular interactions and behavior in the tumor microenvironment adding additional layers of regulation to its function.

Pathways

CD109 participates in the TGF-β signaling pathway and has effects on processes like fibrosis and epithelial-mesenchymal transition (EMT). This involvement connects CD109 functionally to components such as Smad proteins which mediate the signal for TGF-β pathway downstream effects. CD109's modulation within this pathway suggests a regulatory influence that may alter cellular responses under different physiological conditions.

Research associates CD109 with various cancers where it appears to influence tumor progression and metastasis. The protein shows altered expression in glioblastoma and certain leukemias. Its involvement in these cancers links CD109 to other cancer-related proteins such as epidermal growth factor receptor (EGFR) which often shows interplay in signaling pathways involved in cell proliferation and survival. Understanding CD109's function and impact can offer insights into new therapeutic targets in oncology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Modulates negatively TGFB1 signaling in keratinocytes.
See full target information CD109
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