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AB253251

PE Anti-CD167a/DDR1 antibody [51D6]

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(2 Publications)

Mouse Monoclonal CD167a/DDR1 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Cell preparation containing DDR1 protein.

View Alternative Names

CD167a, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE, DDR1, Epithelial discoidin domain-containing receptor 1, Epithelial discoidin domain receptor 1, CD167 antigen-like family member A, Cell adhesion kinase, Discoidin receptor tyrosine kinase, HGK2, Mammary carcinoma kinase 10, Protein-tyrosine kinase 3A, Protein-tyrosine kinase RTK-6, TRK E, Tyrosine kinase DDR, Tyrosine-protein kinase CAK, MCK-10

1 Images
Flow Cytometry - PE Anti-CD167a/DDR1 antibody [51D6] (AB253251)
  • Flow Cyt

Supplier Data

Flow Cytometry - PE Anti-CD167a/DDR1 antibody [51D6] (AB253251)

Flow cytometric anlysis of MCF7 (human breast adenocarcinoma cell line) cells using ab253251. Surface staining.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

51D6

Isotype

IgM

Conjugation

PE

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing DDR1 protein. The exact immunogen used to generate this antibody is proprietary information.

Q08345

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Alternative Products

Primary Antibodies

AB255810

Anti-CD167a/DDR1 antibody [EPR22316-508]

RabMAb|Recombinant

Flow Cytometry - Anti-CD167a/DDR1 antibody [EPR22316-508] (AB255810)

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Primary Antibodies

AB261728

Anti-CD167a/DDR1 antibody [EPR22316-508] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry - Anti-CD167a/DDR1 antibody [EPR22316-508] - BSA and Azide free (AB261728)

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Complementary Products

Assay Kits

AB260063

Human CD167a/DDR1 ELISA Kit

Recombinant|SimpleStep

ELISA - Human CD167a/DDR1 ELISA Kit (AB260063)

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Assay Kits

AB267687

Human CD167a/DDR1 Antibody Pair - BSA and Azide free

RabMAb|Recombinant

Sandwich ELISA - Human CD167a/DDR1 Antibody Pair - BSA and Azide free (AB267687)

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Cell Lines & Lysates

AB280107

Human CD167a/DDR1 knockout MCF7 cell lysate

Western blot - Human CD167a/DDR1 knockout MCF7 cell lysate (AB280107)

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Primary Antibodies

AB279600

PE Anti-IL1 Receptor I/IL-1R-1 antibody [191]

Recombinant

Flow Cytometry - PE Anti-IL1 Receptor I/IL-1R-1 antibody [191] (AB279600)

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Assay Kits

AB260063

Human CD167a/DDR1 ELISA Kit

Recombinant|SimpleStep

ELISA - Human CD167a/DDR1 ELISA Kit (AB260063)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "10 µL for 10^6 Cells", "FlowCyt-species-notes": "<p>Or 10 μL per 100 μL whole blood.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Size-exclusion chromatography
Purification notes
The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
Storage buffer
pH: 8 Preservative: 0.0975% Sodium azide Constituents: Tris buffered saline
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD167a also known as DDR1 (Discoidin Domain Receptor 1) is a receptor tyrosine kinase with a molecular mass of approximately 101 kDa. This protein is expressed widely in various tissues including the thyroid lung kidney and mammary gland. It becomes activated upon collagen binding leading to the regulation of cell adhesion proliferation and extracellular matrix remodeling. The DDR1 protein plays a mechanistic role in responding to unique collagen-rich environments within the body.
Biological function summary

CD167a/DDR1 modulates interactions between cells and their surrounding matrix. It is involved in a complex with collagen mediating signal transduction processes. This interaction is important for cellular biophysical responses driving processes like cell migration and differentiation. In marmoset thyroid tissue DDR1 helps maintain structural integrity and regulates cellular activities important for normal thyroid function.

Pathways

CD167a/DDR1 participates in key signaling pathways including those related to cell adhesion and extracellular matrix remodeling. Specifically it operates within the MAPK/ERK pathway influencing cell cycle dynamics and responses to stress signals. DDR1 also interacts with proteins like SHC and Ras enabling communication between the cell surface and intracellular targets necessary for growth and adaptation.

Mutations or irregular expression of CD167a/DDR1 have implications in cancer and fibrotic diseases. Overexpression or aberration of DDR1 can contribute to tumorigenesis facilitating tumor cell invasion and metastasis. In fibrotic conditions altered DDR1 activity can disrupt normal matrix remodeling linking it to proteins such as collagen I and III which play major roles in these disorders. Understanding DDR1's role offers potential for therapeutic interventions in targeting related pathological conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
See full target information DDR1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 23: PubMed36362214

2022

Characterization of BCMA Expression in Circulating Rare Single Cells of Patients with Plasma Cell Neoplasms.

Applications

Unspecified application

Species

Unspecified reactive species

Libere J Ndacayisaba,Kate E Rappard,Stephanie N Shishido,Sonia M Setayesh,Guilin Tang,Pei Lin,Nicholas Matsumoto,Ching-Ju Hsu,Rafael Nevarez,Carmen Ruiz Velasco,Amin Naghdloo,Eric Yang,Kevin Kelly,James Hicks,Jeremy Mason,Robert Z Orlowski,Elisabet E Manasanch,Peter Kuhn

Nature communications 12:7116 PubMed34893587

2021

Breast tissue regeneration is driven by cell-matrix interactions coordinating multi-lineage stem cell differentiation through DDR1.

Applications

Unspecified application

Species

Unspecified reactive species

Gat Rauner,Dexter X Jin,Daniel H Miller,Todd M Gierahn,Carman M Li,Ethan S Sokol,Yu-Xiong Feng,Robert A Mathis,J Christopher Love,Piyush B Gupta,Charlotte Kuperwasser
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
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