AB33739

PE Anti-CD200 / OX2 antibody [MRC OX90]

Name: PE Anti-CD200 / OX2 antibody [MRC OX90] (ab33739) | Abcam
Brand: Abcam Limited
SKU: AB33739
Price: 275 USD
Availability: InStock

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(1 Publication)

Rat Monoclonal CD200 / OX2 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Protein within Mouse Cd200.

View Alternative Names

CD200, Mox2, Cd200, OX-2 membrane glycoprotein, MRC OX-2 antigen

1 Images

Flow Cytometry - PE Anti-CD200 / OX2 antibody [MRC OX90] (AB33739)

Flow Cyt

Unknown

Flow Cytometry - PE Anti-CD200 / OX2 antibody [MRC OX90] (AB33739)

ab33739 staining of mouse splenocytes.

Unconjugated

Anti-CD200 / OX2 antibody [MRC OX90]
Carrier free

Anti-CD200 / OX2 antibody [MRC OX90] - BSA and Azide free
519 FITC

FITC Anti-CD200 / OX2 antibody [MRC OX90]

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

MRC OX90

Isotype

IgG2a

Conjugation

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Carrier free

Reacts with

Mouse

Applications

Flow Cyt

applications

Immunogen

Recombinant Protein within Mouse Cd200. The exact immunogen used to generate this antibody is proprietary information.

O54901

Specificity

Recognises the mouse CD200 cell surface antigen, also known as OX2.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "10 µL for 10^6 Cells", "FlowCyt-species-notes": "<p>Use 10μl for 10<sup>6</sup> cells in 100μl. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors.</p>" } } }

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Product details

Purified IgG conjugated to R. Phycoerythrin (RPE).

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.

Storage buffer

Preservative: 0.09% Sodium azide Constituents: PBS, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD200 also known as OX2 is a cell surface glycoprotein with a molecular mass of approximately 43 kDa. It plays a mechanical role in immune response regulation. CD200 expression occurs on several cell types such as thymocytes neurons vascular endothelium and splenocytes including cynomolgus monkey splenocytes. This protein generally modulates interactions between cells sending inhibitory signals through its receptor CD200R found on myeloid cells and certain lymphoid cells.

Biological function summary

CD200 regulates the immune system by inhibiting inflammatory responses and maintaining immune homeostasis. It does not act as part of a significant multi-protein complex but directly interacts with CD200R. This interaction promotes an anti-inflammatory state and is important in preventing autoimmune diseases and excessive tissue damage. The expression of CD200 is also an indicator of immune tolerance in various tissues.

Pathways

CD200 is involved in immune regulatory pathways. It plays a pivotal role in the suppression of immune responses through the CD200-CD200R signaling pathway. This pathway is vital for dampening inflammatory processes related to autoimmune reactions and is consequently linked to the maintenance of tissue homeostasis. Proteins related to CD200 through these pathways include CD200R and other molecules involved in immune checkpoint pathways.

CD200 expression correlates with several conditions including cancer and autoimmune diseases. The overexpression of CD200 in certain tumors promotes immune evasion thereby favoring tumor progression. Conversely reduced CD200 levels are associated with autoimmune disorders where a hyperactive immune system attacks self-tissues. Through these disease contexts CD200 operates alongside proteins such as CD200R and OX90 impacting disease progression and immune system modulation.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues (By similarity).

See full target information Cd200

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Neoplasia (New York, N.Y.) 20:1059-1069 PubMed30227305

2018

Analysis of Genomic Alteration in Primary Central Nervous System Lymphoma and the Expression of Some Related Genes.

Applications

Unspecified application

Species

Unspecified reactive species

Yangying Zhou,Wei Liu,Zhijie Xu,Hong Zhu,Desheng Xiao,Weiping Su,Ruolan Zeng,Yuhua Feng,Yumei Duan,Jianhua Zhou,Meizuo Zhong

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

PE Anti-CD200 / OX2 antibody [MRC OX90]

Flow Cytometry - PE Anti-CD200 / OX2 antibody [MRC OX90] (AB33739)

Related conjugates and formulations (3)

Key facts

Host species

Clonality

Clone number

Isotype

Conjugation

Excitation/Emission

Carrier free

Reacts with

Applications

Immunogen

Specificity

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Reactivity data

Product details

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise