Rat Monoclonal CD200 / OX2 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Protein within Mouse Cd200.
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![Flow Cytometry - PE Anti-CD200 / OX2 antibody [MRC OX90] (AB33739), expandable thumbnail](https://content.abcam.com/products/images/pe-cd200-ox2-antibody-mrc-ox90-ab33739--flow-cytometry-img242.jpg/_jcr_content/renditions/webp-475.webp "Flow Cytometry - PE Anti-CD200 / OX2 antibody [MRC OX90] (AB33739)")
Publications
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- Neoplasia (New York, N.Y.) 20:1059-10692018Analysis of Genomic Alteration in Primary Central Nervous System Lymphoma and the Expression of Some Related Genes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYangying Zhou,Wei Liu,Zhijie Xu,Hong Zhu,Desheng Xiao,Weiping Su,Ruolan Zeng,Yuhua Feng,Yumei Duan,Jianhua Zhou,Meizuo ZhongPubMed 30227305
Key facts
- Isotype
- IgG2a
- Host species
- Rat
- Conjugation
- PE
- Excitation/Emission
- Ex: 480;565nm, Em: 578nm
- Storage buffer
Preservative: 0.09% Sodium azide
Constituents: PBS, 1% BSA- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- Recombinant Protein within Mouse Cd200. The exact immunogen used to generate this antibody is proprietary information. Database link O54901
Reactivity data
Select an application| Flow Cyt | |
|---|---|
| Mouse | Tested |
Flow Cyt
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 10 µL for 106 Cells | Notes Use 10μl for 106 cells in 100μl. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors. |
Associated Products
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Target data
Function
Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues (By similarity).
Alternative names
CD200, Mox2, Cd200, OX-2 membrane glycoprotein, MRC OX-2 antigen
Recommended products
Rat Monoclonal CD200 / OX2 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Protein within Mouse Cd200.
Key facts
- Isotype
- IgG2a
- Host species
- Rat
- Conjugation
- PE
- Excitation/Emission
- Ex: 480;565nm, Em: 578nm
- Storage buffer
Preservative: 0.09% Sodium azide
Constituents: PBS, 1% BSA- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- Recombinant Protein within Mouse Cd200. The exact immunogen used to generate this antibody is proprietary information. Database link O54901
- Clone number
- MRC OX90
- Purification technique
- Affinity purification Protein G
- Specificity
Recognises the mouse CD200 cell surface antigen, also known as OX2.
- Concentration
- Purification notes
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
Notes
Purified IgG conjugated to R. Phycoerythrin (RPE).
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CD200 also known as OX2 is a cell surface glycoprotein with a molecular mass of approximately 43 kDa. It plays a mechanical role in immune response regulation. CD200 expression occurs on several cell types such as thymocytes neurons vascular endothelium and splenocytes including cynomolgus monkey splenocytes. This protein generally modulates interactions between cells sending inhibitory signals through its receptor CD200R found on myeloid cells and certain lymphoid cells.
- Biological function summary
CD200 regulates the immune system by inhibiting inflammatory responses and maintaining immune homeostasis. It does not act as part of a significant multi-protein complex but directly interacts with CD200R. This interaction promotes an anti-inflammatory state and is important in preventing autoimmune diseases and excessive tissue damage. The expression of CD200 is also an indicator of immune tolerance in various tissues.
- Pathways
CD200 is involved in immune regulatory pathways. It plays a pivotal role in the suppression of immune responses through the CD200-CD200R signaling pathway. This pathway is vital for dampening inflammatory processes related to autoimmune reactions and is consequently linked to the maintenance of tissue homeostasis. Proteins related to CD200 through these pathways include CD200R and other molecules involved in immune checkpoint pathways.
- Associated diseases and disorders
CD200 expression correlates with several conditions including cancer and autoimmune diseases. The overexpression of CD200 in certain tumors promotes immune evasion thereby favoring tumor progression. Conversely reduced CD200 levels are associated with autoimmune disorders where a hyperactive immune system attacks self-tissues. Through these disease contexts CD200 operates alongside proteins such as CD200R and OX90 impacting disease progression and immune system modulation.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
![Flow Cytometry - PE Anti-CD200 / OX2 antibody [MRC OX90] (ab33739), expandable thumbnail](https://content.abcam.com/products/images/pe-cd200-ox2-antibody-mrc-ox90-ab33739--flow-cytometry-img242.jpg "Flow Cytometry - PE Anti-CD200 / OX2 antibody [MRC OX90] (ab33739)")
Flow Cytometry - PE Anti-CD200 / OX2 antibody [MRC OX90] (ab33739)
ab33739 staining of mouse splenocytes.
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