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AB33366

PE Anti-CD200R antibody [OX108]

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(1 Publication)

Mouse Monoclonal CD200R antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Protein within Human CD200R1.

View Alternative Names

CD200R, CRTR2, MOX2R, OX2R, UNQ2522/PRO6015, CD200R1, Cell surface glycoprotein CD200 receptor 1, CD200 cell surface glycoprotein receptor, Cell surface glycoprotein OX2 receptor 1

1 Images
Flow Cytometry - PE Anti-CD200R antibody [OX108] (AB33366)
  • Flow Cyt

Unknown

Flow Cytometry - PE Anti-CD200R antibody [OX108] (AB33366)

Staining of human peripheral blood lymphocytes with ab33366

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

OX108

Isotype

IgG1

Conjugation

PE

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Recombinant Protein within Human CD200R1. The exact immunogen used to generate this antibody is proprietary information.

Q8TD46

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Alternative Products

Primary Antibodies

AB92794

Anti-CD200R antibody

Western blot - Anti-CD200R antibody (AB92794)

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Primary Antibodies

AB198010

Anti-CD200R antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD200R antibody (AB198010)

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Primary Antibodies

AB34135

PE Anti-CD200R antibody [OX102]

Flow Cytometry - PE Anti-CD200R antibody [OX102] (AB34135)

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Complementary Products

Assay Kits

AB272196

Human CD200R ELISA Kit (CD200R1)

Recombinant|SimpleStep

Sandwich ELISA - Human CD200R ELISA Kit (CD200R1) (AB272196)

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Primary Antibodies

AB254193

Anti-CD200 / OX2 antibody [EPR22412-229]

RabMAb|Recombinant|20ul selling size

Western blot - Anti-CD200 / OX2 antibody [EPR22412-229] (AB254193)

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Proteins & Peptides

AB316573

Recombinant Human CD200R Protein Standard (His tag)

Sandwich ELISA - Recombinant Human CD200R Protein Standard (His tag) (AB316573)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Primary Antibodies

AB200317

Alexa Fluor® 647 Anti-CD45 antibody [EP322Y]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Alexa Fluor® 647 Anti-CD45 antibody [EP322Y] (AB200317)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>Use neat - 1/10. Use 10µl working dilution to label 10<sup>6</sup> cells in 100µl.</p><p><a href='/en-us/products/primary-antibodies/pe-mouse-igg1-b11-6-isotype-control-ab91357'>ab91357</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Storage buffer
pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD200R also known as CD200 receptor is a protein expressed mainly on myeloid cells including macrophages dendritic cells and certain T cells. The protein has a molecular mass of approximately 62 kDa. This receptor is a type I membrane glycoprotein that plays an important role in immune system regulation. It binds to its ligand CD200 protein found on various cell types such as neurons epithelial cells and some immune cells to mediate suppressive effects on the immune response.
Biological function summary

CD200R plays a significant role in controlling the immune response by acting as an inhibitory receptor. When activated it sends signals that dampen immune cell activity which can prevent overactive immune responses and promote tissue homeostasis. This receptor is not part of a large receptor complex but interacts directly with its ligand CD200 to initiate signaling cascades that modulate immune functions. Its primary role lies in preventing unnecessary inflammation and autoimmunity through negative regulation of macrophage activation.

Pathways

CD200R is involved in the regulatory pathways of the immune system. It participates in pathways that manage immune tolerance and its interactions impact pathways related to inflammation control and tissue repair. The CD200R signaling cascades intersect with pathways involving other immune-modulatory proteins such as CD200R1 and CD200R3 which contribute to cellular communication in the immune environment. These pathways play critical roles in downregulating inflammatory responses and maintaining immune balance.

CD200R holds relevance for conditions involving immune dysregulation. It is connected to autoimmune disorders and atopic dermatitis. For example in atopic dermatitis altered expression or function of CD200R may lead to improper immune responses contributing to inflammation. Furthermore CD200R agonists which are molecules that mimic the function of CD200 are an area of interest for developing therapeutic strategies to modulate immune responses. Related proteins such as CD200 and its other receptor variants play active roles in these disorders highlighting the importance of their balanced function to maintain immune homeostasis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.
See full target information CD200R1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Infection and immunity 80:4426-34 PubMed23027536

2012

Haemophilus ducreyi-induced interleukin-10 promotes a mixed M1 and M2 activation program in human macrophages.

Applications

Unspecified application

Species

Human

Wei Li,Barry P Katz,Stanley M Spinola
View all publications
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Product promise

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