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Mouse Monoclonal CD24 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human CD24.

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Images

Flow Cytometry - PE Anti-CD24 antibody [SN3], prediluted (AB30351), expandable thumbnail

Publications

  • Hematological oncology 4:251-91986
    Follicular mantle zone cell subpopulations detected by monoclonal antibody SN3.
    Applications:
    Unspecified application
    Reactive species:
    Unspecified reactive species
    M Barcos,C Pollard,T Fukukawa,B K Seon
    PubMed 3493967
  • Experimental hematology 14:850-51986
    New monoclonal antibodies SN3, SN3a, and SN3b directed to sialic acid of glycoprotein on human non-T leukemia cells.
    Applications:
    Unspecified application
    Reactive species:
    Unspecified reactive species
    T Fukukawa,H Matsuzaki,Y Haruta,H Hara,B K Seon
    PubMed 3489635

Key facts

Isotype

IgG1

Host species

Mouse

Conjugation

PE

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Storage buffer

pH: 7.4
Preservative: 0.09% Sodium azide
Constituents: PBS, 1% BSA

Form

Liquid

Clonality

Monoclonal

Immunogen

  • Native Full Length Protein corresponding to Human CD24. Database link P25063

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
Flow Cyt
Human
Tested

Tested
Tested

Species

Human

Dilution info

10 µL for 106 Cells

Notes

(or 100μl of whole blood).

ab91357 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Associated Products

Select an associated product type

6 products for Alternative Version

    5 products for Alternative Product

      Target data

      Function

      May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).

      Alternative names

      Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen, CD24, CD24A

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      Mouse Monoclonal CD24 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human CD24.

      Alternative names

      Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen, CD24, CD24A

      Key facts

      Isotype

      IgG1

      Conjugation

      PE

      Excitation/Emission

      Ex: 480;565nm, Em: 578nm

      Form

      Liquid

      Clonality

      Monoclonal

      Immunogen
      • Native Full Length Protein corresponding to Human CD24. Database link P25063
      Clone number

      SN3

      Purification technique

      Affinity purification Protein G

      Concentration
      Loading...

      Storage

      Shipped at conditions

      Blue Ice

      Appropriate long-term storage conditions

      +4°C

      Notes

      Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

      If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

      Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

      Supplementary info

      Activity summary

      CD24 also known as heat-stable antigen or CD24A is a glycosylphosphatidylinositol (GPI)-anchored membrane protein with a molecular mass of approximately 30-50 kDa. It is expressed on the surface of many cell types including B cells T cells neutrophils and epithelial cells. CD24 plays a role in cell adhesion and signaling processes impacting immune response and cancer progression. Its expression is often used as a marker in identification and classification procedures such as flow cytometry.

      Biological function summary

      CD24 functions like a molecular "switch" modulating signals sent between cells. It acts as a ligand for multiple receptors and participates in cellular communication especially influencing the immune system. Part of its biological role involves interaction within cellular complexes impacting immune modulation and inflammatory responses. CD24's location at the interface of cellular microenvironments makes it critical for cellular response adaptation to varied external stimuli.

      Pathways

      CD24 participates in both immune signaling and cancer-related pathways. It plays a significant role in the suppression of the immune response often interacting with proteins like Siglec-10 in these pathways. CD24's involvement in these pathways contributes to cell survival and proliferation particularly within cancer development. The protein’s interaction within specified signaling pathways allows it to influence downstream targets that regulate gene expression and cellular functions.

      Associated diseases and disorders

      CD24 has significant connections to cancer and inflammatory diseases. It is highly expressed in various cancers including breast and prostate cancer where it correlates with poor prognosis due to its role in apoptosis evasion and metastasis. CD24 interacts with proteins like HMGB1 and is implicated in inflammatory conditions where it modulates immune cell activity. Extensive research into CD24's involvement in these disorders may lead to targeted therapies including the development of anti-CD24 antibodies for therapeutic interventions.

      Product promise

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      In the unlikely event of one of our products not working as expected, you are covered by our product promise.

      Full details and terms and conditions can be found here:
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      1 product image

      • Flow Cytometry - PE Anti-CD24 antibody [SN3], prediluted (ab30351), expandable thumbnail

        Flow Cytometry - PE Anti-CD24 antibody [SN3], prediluted (ab30351)

        Staining of human peripheral blood granulocytes with NS3 mouse monoclonal phycoerythrin conjugated anti-human CD24 ab30351)

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      Product protocols

      For this product, it's our understanding that no specific protocols are required. You can:

      Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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