Rat Monoclonal CD52 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples.
IgG2b
Rat
PE
Ex: 480;565nm, Em: 578nm
Preservative: 0.09% Sodium azide
Constituents: PBS, 1% BSA
Liquid
Monoclonal
Flow Cyt | |
---|---|
Human | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/1 | Notes ab136585 - Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody. |
Select an associated product type
May play a role in carrying and orienting carbohydrate, as well as having a more specific role.
CDW52, HE5, HE5, CD52, CDW52, CAMPATH-1 antigen, CDw52, Cambridge pathology 1 antigen, Epididymal secretory protein E5, Human epididymis-specific protein 5, He5
Rat Monoclonal CD52 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples.
IgG2b
Rat
PE
Ex: 480;565nm, Em: 578nm
Preservative: 0.09% Sodium azide
Constituents: PBS, 1% BSA
Liquid
Monoclonal
YTH34.5
Affinity purification Protein A
Purified IgG prepared from tissue culture supernatant.
Blue Ice
+4°C
+4°C
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This supplementary information is collated from multiple sources and compiled automatically.
CD52 also known as Campath-1 antigen is a glycoprotein that weighs approximately 12 kDa. It is mainly expressed on the surface of lymphocytes monocytes macrophages and some epithelial cells. This protein is also present on T and B cells making it a reliable marker for these immune cells. CD52's role is primarily in cell adhesion and signaling. The anti-CD52 antibody alemtuzumab targets this antigen specifically indicating its utility in clinical applications.
CD52 plays an essential role in immune response regulation. It is not part of a larger protein complex but interacts dynamically with cell membranes to mediate immune cell activity. By acting as a co-stimulatory molecule for T cells CD52 influences lymphocyte activation and proliferation. This activity becomes significant in modulating immune responses showcasing its importance in immunological pathways.
CD52 heavily influences T cell receptor signaling and cytokine production pathways. It interacts with proteins in these pathways to facilitate effective immune surveillance and response. CD52's engagement in these pathways highlights its collaboration with proteins such as CD3 and CD28 which assist in T cell activation and adaptive immunity. Such interactions highlight CD52's role in maintaining immune homeostasis.
CD52 has substantial relevance in autoimmune diseases and hematological cancers. Multiple sclerosis is one such autoimmune disorder where aberrant CD52 activity affects disease progression. Alemtuzumab an anti-CD52 monoclonal antibody is often used in treatment emphasizing CD52's clinical significance. In hematological malignancies like chronic lymphocytic leukemia CD52 facilitates abnormal lymphocyte survival and proliferation. CD52's interplay with other cell surface proteins such as CD19 further delineates its role in disease pathology and targeting strategies.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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Staining of human peripheral blood lymphocytes with 10ul NEAT ab33082 for 106 cells per 100ul.
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