AB33082

PE Anti-CD52 antibody [YTH34.5]

Name: Anti-CD52 PE antibody [YTH34.5] (ab33082) Rat monoclonal IgG2b | Abcam
Brand: Abcam Limited
SKU: AB33082
Price: 535 USD
Availability: InStock

Be the first to review this product! Submit a review

(1 Publication)

Rat Monoclonal CD52 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples. Cited in 1 publication.

View Alternative Names

CD52, CDW52, HE5, CAMPATH-1 antigen, CDw52, Cambridge pathology 1 antigen, Epididymal secretory protein E5, Human epididymis-specific protein 5, He5

1 Images

Flow Cytometry - PE Anti-CD52 antibody [YTH34.5] (AB33082)

Flow Cyt

Unknown

Flow Cytometry - PE Anti-CD52 antibody [YTH34.5] (AB33082)

Staining of human peripheral blood lymphocytes with 10ul NEAT ab33082 for 10⁶ cells per 100ul.

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

YTH34.5

Isotype

IgG2b

Conjugation

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Carrier free

Reacts with

Human

Applications

Flow Cyt

applications

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/1", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/r-pe-rat-igg2b-kappa-monoclonal-klh-g2b-1-2-isotype-control-ab136585'>ab136585</a> - Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody.</p>" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Purification notes

Purified IgG prepared from tissue culture supernatant.

Storage buffer

Preservative: 0.09% Sodium azide Constituents: PBS, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD52 also known as Campath-1 antigen is a glycoprotein that weighs approximately 12 kDa. It is mainly expressed on the surface of lymphocytes monocytes macrophages and some epithelial cells. This protein is also present on T and B cells making it a reliable marker for these immune cells. CD52's role is primarily in cell adhesion and signaling. The anti-CD52 antibody alemtuzumab targets this antigen specifically indicating its utility in clinical applications.

Biological function summary

CD52 plays an essential role in immune response regulation. It is not part of a larger protein complex but interacts dynamically with cell membranes to mediate immune cell activity. By acting as a co-stimulatory molecule for T cells CD52 influences lymphocyte activation and proliferation. This activity becomes significant in modulating immune responses showcasing its importance in immunological pathways.

Pathways

CD52 heavily influences T cell receptor signaling and cytokine production pathways. It interacts with proteins in these pathways to facilitate effective immune surveillance and response. CD52's engagement in these pathways highlights its collaboration with proteins such as CD3 and CD28 which assist in T cell activation and adaptive immunity. Such interactions highlight CD52's role in maintaining immune homeostasis.

CD52 has substantial relevance in autoimmune diseases and hematological cancers. Multiple sclerosis is one such autoimmune disorder where aberrant CD52 activity affects disease progression. Alemtuzumab an anti-CD52 monoclonal antibody is often used in treatment emphasizing CD52's clinical significance. In hematological malignancies like chronic lymphocytic leukemia CD52 facilitates abnormal lymphocyte survival and proliferation. CD52's interplay with other cell surface proteins such as CD19 further delineates its role in disease pathology and targeting strategies.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

May play a role in carrying and orienting carbohydrate, as well as having a more specific role.

See full target information CD52

style

left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 5:76-86 PubMed15636614

2005

A renewable source of donor cells for repetitive monitoring of T- and B-cell alloreactivity.

Applications

Unspecified application

Species

Unspecified reactive species

Martin S Zand,Anirban Bose,Thuong Vo,Myra Coppage,Tina Pellegrin,Lois Arend,F Eun-Hyung Lee,Adel Bozorgzadeh,Nufatt Leong

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

PE Anti-CD52 antibody [YTH34.5]

Flow Cytometry - PE Anti-CD52 antibody [YTH34.5] (AB33082)

Key facts

Host species

Clonality

Clone number

Isotype

Conjugation

Excitation/Emission

Carrier free

Reacts with

Applications

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Alternative Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Product promise