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AB270651

PE Anti-CD57 antibody [TB01]

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Mouse Monoclonal CD57 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples. Immunogen corresponding to Cell preparation containing CD57 protein.

View Alternative Names

HKN1, LEU7

4 Images
Flow Cytometry - PE Anti-CD57 antibody [TB01] (AB270651)
  • Flow Cyt

Supplier Data

Flow Cytometry - PE Anti-CD57 antibody [TB01] (AB270651)

Flow cytometry analysis of human lymphocytes labeling B3GAT1 at 10 μl reagent / 100 μl of peripheral whole blood and anti-human CD56 APC antibody at 10 μl reagent / 100 μl of peripheral whole blood.

Flow Cytometry - PE Anti-CD57 antibody [TB01] (AB270651)
  • Flow Cyt

Supplier Data

Flow Cytometry - PE Anti-CD57 antibody [TB01] (AB270651)

Flow cytometry analysis of human peripheral whole blood labeling B3GAT1 with ab270651 at 10 μl reagent / 100 μl of peripheral whole blood.

Flow Cytometry - PE Anti-CD57 antibody [TB01] (AB270651)
  • Flow Cyt

Supplier Data

Flow Cytometry - PE Anti-CD57 antibody [TB01] (AB270651)

Flow cytometry analysis of human lymphocytes labeling B3GAT1 with ab270651 at 10 μl reagent / 100 μl of peripheral whole blood and anti-human CD8 Pacific Blue™ antibody at 4 μl reagent / 100 μl of peripheral whole blood.

Flow Cytometry - PE Anti-CD57 antibody [TB01] (AB270651)
  • Flow Cyt

Supplier Data

Flow Cytometry - PE Anti-CD57 antibody [TB01] (AB270651)

Separation of human B3GAT1 positive NK cells (red-filled) from neutrophil granulocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using ab270651 at 10 μl reagent / 100 μl of peripheral whole blood.

  • Unconjugated

    Anti-CD57 antibody [TB01]

  • 519 FITC

    FITC Anti-CD57 antibody [TB01]

  • 660 APC

    APC Anti-CD57 antibody [TB01]

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

TB01

Isotype

IgM

Conjugation

PE

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "10 µL for 10^6 Cells", "FlowCyt-species-notes": "<p>or 100 μl of whole blood.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Size-exclusion chromatography
Purification notes
Purified from TCS. Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Storage buffer
pH: 8 Preservative: 0.0975% Sodium azide Constituents: Tris buffered saline
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD57 also known as HNK-1 is a glycoprotein with a molecular weight of approximately 110 to 150 kDa. It is a marker expressed on the surface of natural killer (NK) cells T lymphocytes and some subsets of CD8+ T cells. Besides you can find this marker in neural tissue. As a surface marker CD57 is used in human immunohistochemistry (IHC) studies to identify cell populations in immune responses and has significant utility in the characterization of lymphocyte subsets.
Biological function summary

CD57 plays a role in immune regulation and cell-mediated cytotoxicity. CD57+ cells which are often mature or post-activation states in NK cells and T lymphocytes are less proliferative but have enhanced cytotoxic abilities. These cells contribute to the immune surveillance against viral infections and tumor cells. CD57 does not belong to any well-known protein complexes but can cooperate with other surface markers to modulate immune functions.

Pathways

CD57+ cell populations participate in the immune system pathways related to cell-mediated immunity and cytotoxic response. The presence of CD57 is often associated with the downregulation of proliferative pathways and the enhancement of cytotoxic pathways. It shows functional overlap with proteins such as CD16 and NKG2D which also play roles in mediating the cytotoxic activity of NK cells.

CD57 is connected to chronic infections and certain autoimmune conditions. In chronic viral infections like HIV CD57+ T cells show a state of replicative senescence where their persistent expression links to disease progression. In autoimmune disorders like rheumatoid arthritis CD57+ T cells are found in the inflamed tissues. This protein works alongside CD8 in conditions of immune dysfunction providing insights into immune status and disease activity.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information CD57
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