AB177274

PE Anti-CD79a antibody [HM47]

Name: Anti-CD79a PE antibody [HM47] (ab177274) Mouse monoclonal IgG1 | Abcam
Brand: Abcam Limited
SKU: AB177274
Price: 260 USD
Availability: InStock

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(3 Publications)

Mouse Monoclonal CD79A antibody - conjugated to PE. Suitable for Flow Cyt (Intra) and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human CD79A aa 200 to C-terminus.

View Alternative Names

CD79a, IGA, MB1, CD79A, B-cell antigen receptor complex-associated protein alpha chain, Ig-alpha, MB-1 membrane glycoprotein, Membrane-bound immunoglobulin-associated protein, Surface IgM-associated protein

3 Images

Flow Cytometry (Intracellular) - PE Anti-CD79a antibody [HM47] (AB177274)

Flow Cyt (Intra)

Supplier Data

Flow Cytometry (Intracellular) - PE Anti-CD79a antibody [HM47] (AB177274)

Flow cytometry analysis of human peripheral blood labeling CD79a using ab177274 at 10 µL/100ul peripheral whole blood. CD19 is labeled with an Anti-human CD19-PE conjugate at 10 µL/100ul peripheral whole blood. Intracellular staining.

Flow Cyt (Intra)

Supplier Data

Flow Cytometry (Intracellular) - PE Anti-CD79a antibody [HM47] (AB177274)

Flow cytometry analysis of human peripheral blood labeling CD79a using ab177274 at 10 µL/100ul peripheral whole blood. Intracellular staining.

Flow Cyt (Intra)

Supplier Data

Flow Cytometry (Intracellular) - PE Anti-CD79a antibody [HM47] (AB177274)

Flow cytometry analysis of human peripheral blood labeling CD79a using ab177274 at 10 µL/100ul peripheral whole blood. CD79a-positive B-cells (Red) are separated from CD79-negative neutrophil granulocytes (Black, dashed line). Intracellular staining.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

HM47

Isotype

IgG1

Conjugation

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Carrier free

Reacts with

Human

Applications

Flow Cyt (Intra)

applications

Immunogen

Synthetic Peptide within Human CD79A aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P11912

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCytIntra-species-checked": "testedAndGuaranteed", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "<p>10 μl reagent / 100 μl of whole blood or 10<sup>6</sup> cells in a suspension.</p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Size-exclusion chromatography

Storage buffer

pH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS, 0.2% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD79a also known as Ig-alpha or MB-1 is a component of the B cell antigen receptor (BCR) complex. It is a transmembrane protein with a molecular mass of approximately 47 kDa. CD79a is part of a heterodimer with CD79b and is mainly expressed on the surface of B lymphocytes. This protein plays a critical mechanical role in signaling transduction through the BCR by associating with membrane-bound immunoglobulin molecules helping to initiate the immune response upon antigen binding.

Biological function summary

This protein acts as an essential mediator in the immune system. CD79a together with CD79b forms part of the BCR complex critical for B cell development and maturation. The BCR complex activates signaling cascades that influence B cell fate decisions such as proliferation differentiation and apoptosis. By transmitting signals from the BCR CD79a helps regulate these cellular functions necessary for efficient immune defense.

Pathways

CD79a plays a pivotal role in the B cell receptor signaling pathway. This pathway involves signaling molecules such as spleen tyrosine kinase (SYK) and phosphoinositide 3-kinase (PI3K) which are activated upon BCR engagement. CD79a acts in concert with other proteins including CD79b and the IgM receptor facilitating downstream signaling cascades that ensure proper B cell responses. Its role is important for linking extracellular antigen recognition to intracellular signaling events.

CD79a is significant in conditions like B cell lymphomas and certain immunodeficiencies. Abnormal expression or mutations in CD79a are associated with some types of non-Hodgkin lymphoma. The protein's interaction with CD79b is particularly relevant as alterations in these proteins' function or expression can impact B cell development and lead to pathogenesis in lymphoproliferative disorders. Consequently CD79a serves as an important biomarker and potential therapeutic target in these diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.

See full target information CD79A

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of mammary gland biology and neoplasia 26:43-66 PubMed33988830

2021

Characterization of Gene Expression Signatures for the Identification of Cellular Heterogeneity in the Developing Mammary Gland.

Applications

Unspecified application

Species

Unspecified reactive species

Samantha Henry,Marygrace C Trousdell,Samantha L Cyrill,Yixin Zhao,Mary J Feigman,Julia M Bouhuis,Dominik A Aylard,Adam Siepel,Camila O Dos Santos

Journal of tissue engineering and regenerative med 13:433-445 PubMed30650247

2019

Effect of donor variation on osteogenesis and vasculogenesis in hydrogel cocultures.

Applications

Unspecified application

Species

Unspecified reactive species

Iris Pennings,Lukas A van Dijk,Juliet van Huuksloot,Joost O Fledderus,Koen Schepers,A Koen Braat,Edward C Hsiao,Emilie Barruet,Blanca M Morales,Marianne C Verhaar,Antoine J W P Rosenberg,Debby Gawlitta

Stem cells international 2017:9717353 PubMed28781597

2017

Mesenchymal Stromal Cells Accelerate Epithelial Tight Junction Assembly via the AMP-Activated Protein Kinase Pathway, Independently of Liver Kinase B1.

Applications

Flow Cyt

Species

Dog

P Rowart,P Erpicum,J-M Krzesinski,M Sebbagh,F Jouret

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

PE Anti-CD79a antibody [HM47]

Flow Cytometry (Intracellular) - PE Anti-CD79a antibody [HM47] (AB177274)

Flow Cytometry (Intracellular) - PE Anti-CD79a antibody [HM47] (AB177274)

Flow Cytometry (Intracellular) - PE Anti-CD79a antibody [HM47] (AB177274)

Key facts

Host species

Clonality

Clone number

Isotype

Conjugation

Excitation/Emission

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

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