AB24904

PE Anti-CD90 / Thy1 antibody [G7]

Name: Anti-CD90 / Thy1 PE antibody [G7] (ab24904) Rat monoclonal IgG2c | Abcam
Brand: Abcam Limited
SKU: AB24904
Price: 160 USD
Availability: InStock
Rating: 4 (1 reviews)

(1 Review)

(15 Publications)

Rat Monoclonal CD90 / Thy1 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 15 publications.

View Alternative Names

CD90, Thy-1, Thy1, Thy-1 membrane glycoprotein, Thy-1 antigen

1 Images

Flow Cytometry - PE Anti-CD90 / Thy1 antibody [G7] (AB24904)

Flow Cyt

Unknown

Flow Cytometry - PE Anti-CD90 / Thy1 antibody [G7] (AB24904)

Flow cytometry analysis staining CD90 / Thy1 in mouse splenocytes using ab24904 at a dilution of 0.03 μg/10⁶ cells.

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

Isotype

IgG2c

Light chain type

kappa

Conjugation

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Carrier free

Reacts with

Mouse

Applications

Flow Cyt

applications

Epitope

Thy 1 epitope region A

Specificity

ab24904 is specific for Thy 1.1 and Thy 1.2 alloantigens (Thy 1 epitope region A).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "2 µg for 10^6 Cells", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/pe-rat-igg2c-kappa-monoclonal-sb68b-isotype-control-ab154450'>ab154450</a> - Rat monoclonal IgG2c, is suitable for use as an isotype control with this antibody.</p>" } } }

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Product details

ab24904 stimulates T-cell proliferation and IL2 secretion, via signalling through the T-cell receptor/CD3 complex. ab24904 has also been reported to promote apoptosis of thymocytes and CTL clones and to mediate adhesion of thymocytes to thymic stroma.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification

Storage buffer

pH: 7.3 Preservative: 0.09% Sodium azide Constituents: PBS, 16% Sucrose

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Storage information

Store in the dark

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD90 also known as Thy1 is a glycoprotein with a molecular mass of approximately 25-37 kDa. It is highly conserved across species and found on the surface of various cell types including fibroblasts neurons and endothelial cells. CD90 is expressed in these cells in tissues such as the brain thymus and lungs. Researchers use anti-CD90 antibodies for detection often in combination with CD90 FITC in immunofluorescence assays. CD90 serves as a useful cell marker particularly in identifying mesenchymal stem cells (MSCs).

Biological function summary

CD90 plays a role in cell-cell and cell-matrix interactions contributing to cellular adhesion migration and signal transduction. It functions as part of a complex involving integrins which mediate its interaction with the extracellular matrix. This protein also influences T-cell activation reflecting its importance in immune response regulation. Its presence aids in modulating response to injury and promoting tissue repair due to its association with stem and progenitor cells.

Pathways

CD90 engagement affects focal adhesion and MAPK signaling pathways. It interacts with integrins like αvβ3 and α5β1 influencing cell movement and proliferation processes. CD90 involvement in these pathways allows it to regulate responses important for cell survival and communication within various tissues. These interactions highlight the protein's role in maintaining cellular homeostasis and regulating physiological processes.

CD90 has associations with fibrosis and cancer. In fibrotic conditions CD90 expression affects fibroblast activity influencing tissue scarring in organs such as the liver and lungs. In cancer CD90 modifies tumor progression and metastasis by impacting cell adhesion and migration with connections to proteins like TGF-beta which further drive these processes. Understanding CD90 in disease contexts facilitates the development of therapeutic strategies aimed at modulating its activity.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

See full target information Thy1

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Publications (15)

Recent publications for all applications. Explore the full list and refine your search

Journal of nanobiotechnology 22:540 PubMed39237942

2024

Enhanced osteogenic differentiation in 3D hydrogel scaffold via macrophage mitochondrial transfer.

Applications

Unspecified application

Species

Unspecified reactive species

Shui Qiu,Lili Cao,Dingding Xiang,Shu Wang,Di Wang,Yiyi Qian,Xiaohua Li,Xiaoshu Zhou

Cancer cell 42:101-118.e11 PubMed38157863

2024

EGFR-activated myofibroblasts promote metastasis of pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Gianluca Mucciolo,Joaquín Araos Henríquez,Muntadher Jihad,Sara Pinto Teles,Judhell S Manansala,Wenlong Li,Sally Ashworth,Eloise G Lloyd,Priscilla S W Cheng,Weike Luo,Akanksha Anand,Ashley Sawle,Anna Piskorz,Giulia Biffi

Journal of nanobiotechnology 21:459 PubMed38037135

2023

Biomimetic composite hydrogel promotes new bone formation in rat bone defects through regulation of miR-19b-3p/WWP1 axis by loaded extracellular vesicles.

Applications

Unspecified application

Species

Unspecified reactive species

Rongkang Guo,Chaohan Wu,Fan Liu,Tianhua Dong,Tao Zhang

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 37:e22711 PubMed36520091

2022

Melatonin promotes the restoration of bone defects via enhancement of miR-335-5p combined with inhibition of TNFα/NF-κB signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Yiyang Li,Huanshuai Guan,Run Tian,Ning Kong,Guanzhi Liu,Zhe Li,Kunzheng Wang,Pei Yang

Regenerative biomaterials 8:rbab051 PubMed34603743

2021

Porous tantalum-composited gelatin nanoparticles hydrogel integrated with mesenchymal stem cell-derived endothelial cells to construct vascularized tissue .

Applications

Unspecified application

Species

Unspecified reactive species

Zhenhua Zhao,Mang Wang,Fei Shao,Ge Liu,Junlei Li,Xiaowei Wei,Xiuzhi Zhang,Jiahui Yang,Fang Cao,Qiushi Wang,Huanan Wang,Dewei Zhao

Journal of cellular biochemistry 122:1791-1804 PubMed34397115

2021

Mesenchymal stem cell and endothelial progenitor cells coinjection improves LPS-induced lung injury via Tie2 activation and downregulation of the TLR4/MyD88 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Sadaf Hoseinnia,Maryam Ghane,Jamile Norouzi,Farzaneh Hosseini

Cancer cell 39:1227-1244.e20 PubMed34297917

2021

Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity.

Applications

Unspecified application

Species

Unspecified reactive species

Colin Hutton,Felix Heider,Adrian Blanco-Gomez,Antonia Banyard,Alexander Kononov,Xiaohong Zhang,Saadia Karim,Viola Paulus-Hock,Dale Watt,Nina Steele,Samantha Kemp,Elizabeth K J Hogg,Joanna Kelly,Rene-Filip Jackstadt,Filipa Lopes,Matteo Menotti,Luke Chisholm,Angela Lamarca,Juan Valle,Owen J Sansom,Caroline Springer,Angeliki Malliri,Richard Marais,Marina Pasca di Magliano,Santiago Zelenay,Jennifer P Morton,Claus Jørgensen

PloS one 15:e0228889 PubMed32045450

2020

Mesenchymal stem cells reduce alcoholic hepatitis in mice via suppression of hepatic neutrophil and macrophage infiltration, and of oxidative stress.

Applications

Unspecified application

Species

Unspecified reactive species

Yue-Meng Wan,Zhi-Qiang Li,Chang Liu,Yue-Feng He,Men-Jie Wang,Xi-Nan Wu,Yuan Zhang,Yu-Hua Li

Nature protocols 9:1662-81 PubMed24945383

2014

Isolation and characterization of resident endogenous c-Kit+ cardiac stem cells from the adult mouse and rat heart.

Applications

Unspecified application

Species

Unspecified reactive species

Andrew J Smith,Fiona C Lewis,Iolanda Aquila,Cheryl D Waring,Aurora Nocera,Valter Agosti,Bernardo Nadal-Ginard,Daniele Torella,Georgina M Ellison

PloS one 8:e69560 PubMed23894503

2013

CD24 expression identifies teratogen-sensitive fetal neural stem cell subpopulations: evidence from developmental ethanol exposure and orthotopic cell transfer models.

Applications

Flow Cyt

Species

Mouse

Joseph D Tingling,Shameena Bake,Rhonda Holgate,Jeremy Rawlings,Phillips P Nagsuk,Jayashree Chandrasekharan,Sarah L Schneider,Rajesh C Miranda

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

PE Anti-CD90 / Thy1 antibody [G7]

Flow Cytometry - PE Anti-CD90 / Thy1 antibody [G7] (AB24904)

Key facts

Host species

Clonality

Clone number

Isotype

Light chain type

Conjugation

Excitation/Emission

Carrier free

Reacts with

Applications

Epitope

Specificity

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (15)

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