Rat Monoclonal CD90 / Thy1 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 12 publications.
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![Flow Cytometry - PE Anti-CD90 / Thy1 antibody [G7] (AB24904), expandable thumbnail](https://content.abcam.com/products/images/pe-cd90-thy1-antibody-g7-ab24904--flow-cytometry-img63730.jpg/_jcr_content/renditions/webp-475.webp "Flow Cytometry - PE Anti-CD90 / Thy1 antibody [G7] (AB24904)")
Publications
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- Journal of nanobiotechnology 21:4592023Biomimetic composite hydrogel promotes new bone formation in rat bone defects through regulation of miR-19b-3p/WWP1 axis by loaded extracellular vesicles.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRongkang Guo,Chaohan Wu,Fan Liu,Tianhua Dong,Tao ZhangPubMed 38037135
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology 37:e227112022Melatonin promotes the restoration of bone defects via enhancement of miR-335-5p combined with inhibition of TNFα/NF-κB signaling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYiyang Li,Huanshuai Guan,Run Tian,Ning Kong,Guanzhi Liu,Zhe Li,Kunzheng Wang,Pei YangPubMed 36520091
- Regenerative biomaterials 8:rbab0512021Porous tantalum-composited gelatin nanoparticles hydrogel integrated with mesenchymal stem cell-derived endothelial cells to construct vascularized tissue .Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhenhua Zhao,Mang Wang,Fei Shao,Ge Liu,Junlei Li,Xiaowei Wei,Xiuzhi Zhang,Jiahui Yang,Fang Cao,Qiushi Wang,Huanan Wang,Dewei ZhaoPubMed 34603743
- Cancer cell 39:1227-1244.e202021Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesColin Hutton,Felix Heider,Adrian Blanco-Gomez,Antonia Banyard,Alexander Kononov,Xiaohong Zhang,Saadia Karim,Viola Paulus-Hock,Dale Watt,Nina Steele,Samantha Kemp,Elizabeth K J Hogg,Joanna Kelly,Rene-Filip Jackstadt,Filipa Lopes,Matteo Menotti,Luke Chisholm,Angela Lamarca,Juan Valle,Owen J Sansom,Caroline Springer,Angeliki Malliri,Richard Marais,Marina Pasca di Magliano,Santiago Zelenay,Jennifer P Morton,Claus JørgensenPubMed 34297917
- PloS one 15:e02288892020Mesenchymal stem cells reduce alcoholic hepatitis in mice via suppression of hepatic neutrophil and macrophage infiltration, and of oxidative stress.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYue-Meng Wan et. al.PubMed 32045450
- Nature protocols 9:1662-812014Isolation and characterization of resident endogenous c-Kit+ cardiac stem cells from the adult mouse and rat heart.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAndrew J Smith,Fiona C Lewis,Iolanda Aquila,Cheryl D Waring,Aurora Nocera,Valter Agosti,Bernardo Nadal-Ginard,Daniele Torella,Georgina M EllisonPubMed 24945383
- PloS one 8:e695602013CD24 expression identifies teratogen-sensitive fetal neural stem cell subpopulations: evidence from developmental ethanol exposure and orthotopic cell transfer models.
- The Journal of experimental medicine 179:785-961994Thy-1 triggers mouse thymocyte apoptosis through a bcl-2-resistant mechanism.Applications:Unspecified applicationReactive species:Unspecified reactive speciesA O Hueber,G Raposo,M Pierres,H T HePubMed 7906706
- Journal of immunology (Baltimore, Md. : 1950) 149:1583-921992Activation-driven T cell death. II. Quantitative differences alone distinguish stimuli triggering nontransformed T cell proliferation or death.Applications:Unspecified applicationReactive species:Unspecified reactive speciesD S Ucker,J Meyers,P S ObermillerPubMed 1380534
- The Journal of experimental medicine 173:515-81991Thy-1 supports adhesion of mouse thymocytes to thymic epithelial cells through a Ca2(+)-independent mechanism.Applications:Unspecified applicationReactive species:Unspecified reactive speciesH T He,P Naquet,D Caillol,M PierresPubMed 1671083
Key facts
- Isotype
- IgG2c
- Host species
- Rat
- Conjugation
- PE
- Excitation/Emission
- Ex: 480;565nm, Em: 578nm
- Storage buffer
pH: 7.3
Preservative: 0.09% Sodium azide
Constituents: PBS, 16% Sucrose- Form
- Liquid
- Clonality
- Monoclonal
Reactivity data
Select an application| Flow Cyt | |
|---|---|
| Mouse | Tested |
Flow Cyt
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 2 µg for 106 Cells | Notes ab154450 - Rat monoclonal IgG2c, is suitable for use as an isotype control with this antibody. |
Associated Products
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4 products for Alternative Version
8 products for Alternative Product
Target data
Function
May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
Alternative names
CD90, Thy-1, Thy1, Thy-1 membrane glycoprotein, Thy-1 antigen
Recommended products
Rat Monoclonal CD90 / Thy1 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 12 publications.
Key facts
- Isotype
- IgG2c
- Host species
- Rat
- Conjugation
- PE
- Excitation/Emission
- Ex: 480;565nm, Em: 578nm
- Storage buffer
pH: 7.3
Preservative: 0.09% Sodium azide
Constituents: PBS, 16% Sucrose- Form
- Liquid
- Clonality
- Monoclonal
- Clone number
- G7
- Purification technique
- Affinity purification
- Specificity
ab24904 is specific for Thy 1.1 and Thy 1.2 alloantigens (Thy 1 epitope region A).
- Epitope
- Thy 1 epitope region A
- Light chain type
- kappa
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store in the dark
Notes
ab24904 stimulates T-cell proliferation and IL2 secretion, via signalling through the T-cell receptor/CD3 complex. ab24904 has also been reported to promote apoptosis of thymocytes and CTL clones and to mediate adhesion of thymocytes to thymic stroma.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CD90 also known as Thy1 is a glycoprotein with a molecular mass of approximately 25-37 kDa. It is highly conserved across species and found on the surface of various cell types including fibroblasts neurons and endothelial cells. CD90 is expressed in these cells in tissues such as the brain thymus and lungs. Researchers use anti-CD90 antibodies for detection often in combination with CD90 FITC in immunofluorescence assays. CD90 serves as a useful cell marker particularly in identifying mesenchymal stem cells (MSCs).
- Biological function summary
CD90 plays a role in cell-cell and cell-matrix interactions contributing to cellular adhesion migration and signal transduction. It functions as part of a complex involving integrins which mediate its interaction with the extracellular matrix. This protein also influences T-cell activation reflecting its importance in immune response regulation. Its presence aids in modulating response to injury and promoting tissue repair due to its association with stem and progenitor cells.
- Pathways
CD90 engagement affects focal adhesion and MAPK signaling pathways. It interacts with integrins like αvβ3 and α5β1 influencing cell movement and proliferation processes. CD90 involvement in these pathways allows it to regulate responses important for cell survival and communication within various tissues. These interactions highlight the protein's role in maintaining cellular homeostasis and regulating physiological processes.
- Associated diseases and disorders
CD90 has associations with fibrosis and cancer. In fibrotic conditions CD90 expression affects fibroblast activity influencing tissue scarring in organs such as the liver and lungs. In cancer CD90 modifies tumor progression and metastasis by impacting cell adhesion and migration with connections to proteins like TGF-beta which further drive these processes. Understanding CD90 in disease contexts facilitates the development of therapeutic strategies aimed at modulating its activity.
Product promise
Tested
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Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
![Flow Cytometry - PE Anti-CD90 / Thy1 antibody [G7] (ab24904), expandable thumbnail](https://content.abcam.com/products/images/pe-cd90-thy1-antibody-g7-ab24904--flow-cytometry-img63730.jpg "Flow Cytometry - PE Anti-CD90 / Thy1 antibody [G7] (ab24904)")
Flow Cytometry - PE Anti-CD90 / Thy1 antibody [G7] (ab24904)
Flow cytometry analysis staining CD90 / Thy1 in mouse splenocytes using ab24904 at a dilution of 0.03 μg/106 cells.
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