AB234233

PE/Cy5® Anti-CD83 antibody [HB15e]

Name: Anti-CD83 PE/Cy5® antibody [HB15e] (ab234233) Mouse monoclonal IgG1 | Abcam
Brand: Abcam Limited
SKU: AB234233
Price: 410 USD
Availability: InStock

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(1 Publication)

Mouse Monoclonal CD83 antibody - conjugated to PE/Cy5®. Suitable for Flow Cyt and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing CD83 protein.

View Alternative Names

CD83, CD83 antigen, hCD83, B-cell activation protein, Cell surface protein HB15

2 Images

Flow Cytometry - PE/Cy5® Anti-CD83 antibody [HB15e] (AB234233)

Flow Cyt

Supplier Data

Flow Cytometry - PE/Cy5® Anti-CD83 antibody [HB15e] (AB234233)

Flow Cytometry analysis of IFN gamma-activated human peripheral blood labeling CD83 with ab234233. Surface staining.

Flow Cyt

Supplier Data

Flow Cytometry - PE/Cy5® Anti-CD83 antibody [HB15e] (AB234233)

Flow cytometry analysis of human peripheral blood mononuclear cells stimulated with IFN-alpha2 stained with 4μl ab234233 per 100μl sample

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

HB15e

Isotype

IgG1

Light chain type

kappa

Conjugation

PE/Cy5®

Excitation/Emission

Ex: 496nm, Em: 667nm

Carrier free

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing CD83 protein. The exact immunogen used to generate this antibody is proprietary information.

Q01151

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "4 µL for 10^6 Cells", "FlowCyt-species-notes": "<p></p>" }, "Primates": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Size-exclusion chromatography

Purification notes

ab234233 is conjugated with tandem dye PE-Cy™5 under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.

Storage buffer

pH: 7.4 Preservative: 0.0975% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Storage information

Store in the dark

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD83 also known as 3D11 in some contexts is a protein with important roles in the immune system. The CD83 protein is a glycoprotein with a molecular mass of approximately 45 kDa. It is expressed in various immune cells including dendritic cells B cells thymic epithelial cells and activated T cells. CD83 acts as a surface marker during the maturation and activation of these cells. This characteristic makes it a useful marker in immunological studies often referred to by scientists as the CD83 marker.

Biological function summary

The primary role of CD83 involves the regulation of immune responses. It functions by modulating the activity and communication of immune cells especially impacting the antigen-presenting capabilities of dendritic cells. CD83 also plays a role in promoting the maturation of these cells and influencing T-cell responses. Although CD83 is not generally recognized as a part of a complex its interactions with other cell surface molecules are significant for immune system function.

Pathways

CD83 has notable involvement in immune signaling pathways including the NF-kB and JAK/STAT pathways. These pathways are critical for transmitting signals that influence cell survival proliferation and activation. Through these pathways CD83 interacts with proteins such as cytokines and growth factors which further modulate their effects on immune cells and their responses.

Understanding CD83’s role provides insights into conditions like autoimmune diseases and immune deficiencies. In autoimmune diseases irregular expression or function of CD83 can disrupt normal immune response contributing to pathogenesis. Its relationship with other proteins such as CD28 in T-cell activation underlies its involvement in disorders characterized by immune dysregulation. Furthermore CD83 expression profiles may help decipher cancer immune evasion mechanisms providing possible therapeutic targets.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.

See full target information CD83

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell biology and toxicology 41:23 PubMed39775116

2025

Exosomal NEDD4L derived from HG+oxLDL-induced vascular endothelial cells accelerates macrophage M1 polarization and oxLDL uptake by ubiquitinating IκBα and PPARγ.

Applications

Unspecified application

Species

Unspecified reactive species

Guozhu Chen,Yisong Pei,Peng Jiang,Qiaoling Ye,Zulong Xie,Laxman Gyawali

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

PE/Cy5® Anti-CD83 antibody [HB15e]

Flow Cytometry - PE/Cy5® Anti-CD83 antibody [HB15e] (AB234233)

Flow Cytometry - PE/Cy5® Anti-CD83 antibody [HB15e] (AB234233)

Key facts

Host species

Clonality

Clone number

Isotype

Light chain type

Conjugation

Excitation/Emission

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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