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AB95823

PE/Cy5® Anti-Ly76 antibody [TER-119]

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(1 Publication)

Rat Monoclonal Ly76 antibody - conjugated to PE/Cy5®. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing Ly76 protein.

View Alternative Names

Ly 76, Lymphocyte antigen 76, TER 119

1 Images
Flow Cytometry - PE/Cy5® Anti-Ly76 antibody [TER-119] (AB95823)
  • Flow Cyt

Unknown

Flow Cytometry - PE/Cy5® Anti-Ly76 antibody [TER-119] (AB95823)

Flow cytometry staining of C57Bl/6 bone marrow cells with staining buffer (autofluorescence) (open histogram) or 0.125 µg of ab95823 (filled histogram). Total cells were used for analysis.

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Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

TER-119

Isotype

IgG2b

Light chain type

kappa

Conjugation

PE/Cy5®

Excitation/Emission

Ex: 496nm, Em: 667nm

Carrier free

No

Reacts with

Mouse

Applications

Flow Cyt

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "0.125-0.25 µg for 10^5 Cells", "FlowCyt-species-notes": "<p>Cell number should be determined empirically but can range from 10<sup>5</sup> to 10<sup>8</sup> cells/test (based on a test volume of 100 µl).</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.2 Preservative: 0.09% Sodium azide Constituents: PBS, 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Ly76 also known as glycophorin A is a well-defined protein expressed predominantly on the surface of red blood cells. This protein consisting of approximately 152 amino acids and with a molecular mass of around 31 kilodaltons plays a role in maintaining cell integrity. Glycophorin A is responsible for making the cell membrane more pliable facilitating proper red blood cell function. It is also important for serving as a receptor or a carrier for various molecules that interact with the cell surface.
Biological function summary

Glycophorin A contributes to the structural stability and flexibility of erythrocyte membranes. It participates as a part of the complex with other proteins such as band 3 and protein 4.2 which support the stability of the membrane's cytoskeletal architecture. This interaction is important for the proper shape and resilience of red blood cells enabling them to withstand shear stress as they travel through narrow capillaries. Additionally glycophorin A carries carbohydrate structures that can serve as antigens which are vital for immune recognition.

Pathways

Glycophorin A engages in pathways related to erythrocyte function and immune interactions. It interacts with proteins integral to maintaining red blood cell membrane structure and flexibility such as band 3 and spectrin. Moreover glycophorin A plays a role in pathways involved in the attachment of various pathogens which exploit this protein to gain entry into the erythrocytes. These interactions highlight the protein’s significance within the hematological cellular environment and immune response mechanisms.

Glycophorin A is associated with conditions affecting red blood cells such as hereditary spherocytosis and malaria. Hereditary spherocytosis involves abnormalities in erythrocyte membrane proteins where glycophorin A alongside proteins like ankyrin and spectrin can show altered expression or function leading to morphological changes in red blood cells. In malaria the Plasmodium parasite exploits glycophorin A for entry into red blood cells where mutations in glycophorin A can confer some resistance to infection. Understanding its role in these conditions underlines the protein's importance in both physiological and pathological contexts.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Ly76
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

British journal of haematology 109:280-7 PubMed10848813

2000

The monoclonal antibody TER-119 recognizes a molecule associated with glycophorin A and specifically marks the late stages of murine erythroid lineage.

Applications

Unspecified application

Species

Unspecified reactive species

T Kina,K Ikuta,E Takayama,K Wada,A S Majumdar,I L Weissman,Y Katsura
View all publications
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Product promise

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