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AB272336

PE/Cy7® Anti-CD200 / OX2 antibody [OX-104]

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(1 Publication)

Mouse Monoclonal CD200 / OX2 antibody - conjugated to PE/Cy7®. Suitable for Flow Cyt and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CD200.

View Alternative Names

CD200, MOX1, MOX2, My033, OX-2 membrane glycoprotein

3 Images
Flow Cytometry - PE/Cy7® Anti-CD200 / OX2 antibody [OX-104] (AB272336)
  • Flow Cyt

Supplier Data

Flow Cytometry - PE/Cy7® Anti-CD200 / OX2 antibody [OX-104] (AB272336)

Flow cytometric analysis of human peripheral whole blood labeling CD200 with ab272336 at 4 μL / 106 cells (in 100 μL cell suspension) and an APC-labeled anti-CD19 antibody.

Flow Cytometry - PE/Cy7® Anti-CD200 / OX2 antibody [OX-104] (AB272336)
  • Flow Cyt

Supplier Data

Flow Cytometry - PE/Cy7® Anti-CD200 / OX2 antibody [OX-104] (AB272336)

Flow cytometric analysis showing separation of CD200 positive B cells (red) from neutrophils (dashed) using ab272336 at 4 μL / 106 cells to label CD200 in human peripheral whole blood (100 μL).

Flow Cytometry - PE/Cy7® Anti-CD200 / OX2 antibody [OX-104] (AB272336)
  • Flow Cyt

Supplier Data

Flow Cytometry - PE/Cy7® Anti-CD200 / OX2 antibody [OX-104] (AB272336)

Flow cytometric analysis of human peripheral whole blood labeling CD200 with ab272336 at 4 μL / 106 cells (in 100 μL cell suspension).

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

OX-104

Isotype

IgG1

Light chain type

kappa

Conjugation

PE/Cy7®

Excitation/Emission

Ex: 565nm, Em: 778nm

Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Recombinant Fragment Protein within Human CD200. The exact immunogen used to generate this antibody is proprietary information.

P41217

Epitope

extracellular

Specificity

The mouse monoclonal antibody OX-104 recognizes an extracellular epitope of CD200.

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Secondary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "4 µL for 10^6 Cells", "FlowCyt-species-notes": "<p>In a volume of 100 μL cell suspension.</p>" } } }
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Product details

This product or portions thereof is manufactured under license from Carnegie Mellon University under U.S. Patent Number 5, 268, 486 and related patents. Cy® and CyDye® are trademarks of Cytiva.
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Properties and storage information

Form
Liquid
Purification technique
Size-exclusion chromatography
Purification notes
Purified from TCS.
Storage buffer
pH: 7.4 Preservative: 0.0975% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD200 also known as OX2 is a cell surface glycoprotein with a molecular mass of approximately 43 kDa. It plays a mechanical role in immune response regulation. CD200 expression occurs on several cell types such as thymocytes neurons vascular endothelium and splenocytes including cynomolgus monkey splenocytes. This protein generally modulates interactions between cells sending inhibitory signals through its receptor CD200R found on myeloid cells and certain lymphoid cells.
Biological function summary

CD200 regulates the immune system by inhibiting inflammatory responses and maintaining immune homeostasis. It does not act as part of a significant multi-protein complex but directly interacts with CD200R. This interaction promotes an anti-inflammatory state and is important in preventing autoimmune diseases and excessive tissue damage. The expression of CD200 is also an indicator of immune tolerance in various tissues.

Pathways

CD200 is involved in immune regulatory pathways. It plays a pivotal role in the suppression of immune responses through the CD200-CD200R signaling pathway. This pathway is vital for dampening inflammatory processes related to autoimmune reactions and is consequently linked to the maintenance of tissue homeostasis. Proteins related to CD200 through these pathways include CD200R and other molecules involved in immune checkpoint pathways.

CD200 expression correlates with several conditions including cancer and autoimmune diseases. The overexpression of CD200 in certain tumors promotes immune evasion thereby favoring tumor progression. Conversely reduced CD200 levels are associated with autoimmune disorders where a hyperactive immune system attacks self-tissues. Through these disease contexts CD200 operates alongside proteins such as CD200R and OX90 impacting disease progression and immune system modulation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.
See full target information CD200
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 26:203-219 PubMed36450891

2022

Comprehensive transcriptomic profiling and mutational landscape of primary gastric linitis plastica.

Applications

Unspecified application

Species

Unspecified reactive species

Zhu Liu,Lian-Lian Hong,Jin-Sen Zheng,Zhe-Nan Ling,Zhi-Long Zhang,Ya-Nan Qi,Xin-Yu Zhang,Tian-Yu Zhu,Jiu-Li Wang,Jing Han,Xiang-Liu Chen,Qi-Ming Yu,Shi Wang,Pei Li,Zhi-Qiang Ling
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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