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AB270682

PE/Cy7® Anti-Mannose Receptor antibody [15-2]

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(6 Publications)

Mouse Monoclonal Mannose Receptor antibody - conjugated to PE/Cy7®. Suitable for Flow Cyt and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human MRC1.

View Alternative Names

CD206, CLEC13D, CLEC13DL, MRC1L1, MRC1, Macrophage mannose receptor 1, MMR, C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, Human mannose receptor, Macrophage mannose receptor 1-like protein 1, hMR

3 Images
Flow Cytometry - PE/Cy7® Anti-Mannose Receptor antibody [15-2] (AB270682)
  • Flow Cyt

Supplier Data

Flow Cytometry - PE/Cy7® Anti-Mannose Receptor antibody [15-2] (AB270682)

Flow cytometry analysis of human stimulated monocytes (GM-CSF + IL-4) labeling Mannose Receptor (CD206) using ab270682 (Red). Surface staining.

Control : Non-stimulated lymphocytes (Black).

Flow Cytometry - PE/Cy7® Anti-Mannose Receptor antibody [15-2] (AB270682)
  • Flow Cyt

Supplier Data

Flow Cytometry - PE/Cy7® Anti-Mannose Receptor antibody [15-2] (AB270682)

Flow cytometry analysis of stimulated human monocytes (GM-CSF + IL-4) labeling Mannose Receptor (CD206) using ab270682. Surface staining.

Flow Cytometry - PE/Cy7® Anti-Mannose Receptor antibody [15-2] (AB270682)
  • Flow Cyt

Supplier Data

Flow Cytometry - PE/Cy7® Anti-Mannose Receptor antibody [15-2] (AB270682)

Flow cytometry analysis of stimulated human monocytes (GM-CSF + IL-4) labeling Mannose Receptor (CD206) using ab270682. Surface staining.

Control is an anti-CD11c (BU15) APC antibody (10 μl reagent per million cells in 100 μl of cell suspension).

  • Unconjugated

    Anti-Mannose Receptor antibody [15-2]

  • 695 PerCP/Cy5.5®

    PerCP/Cy5.5® Anti-Mannose Receptor antibody [15-2]

  • 519 FITC

    FITC Anti-Mannose Receptor antibody [15-2]

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

15-2

Isotype

IgG1

Light chain type

kappa

Conjugation

PE/Cy7®

Excitation/Emission

Ex: 565nm, Em: 778nm

Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Native Full Length Protein corresponding to Human MRC1.

P22897

Specificity

This antibody 15-2 (also known as MR15-2) recognizes an extracellular epitope of CD206 (macrophage mannose receptor, MMR), a 162-175 kDa type I transmembrane protein expressed mainly on macrophages, dendritic cells and hepatic or lymphatic endothelial cells, but not on monocytes.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "4 µL for 10^6 Cells", "FlowCyt-species-notes": "<p>The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 10<sup>6</sup> cells in suspension.</p>" } } }
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Product details

This product or portions thereof is manufactured under license from Carnegie Mellon University under U.S. Patent Number 5, 268, 486 and related patents. Cy® and CyDye® are trademarks of Cytiva.
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Properties and storage information

Form
Liquid
Purification technique
Size-exclusion chromatography
Storage buffer
pH: 7.4 Preservative: 0.0975% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Mannose Receptor also known as CD206 or MRC1 is a type of C-type lectin receptor with a molecular weight of 175 kDa. It is expressed on the surface of macrophages and dendritic cells. This receptor binds to complex carbohydrates like mannose and fucose found on pathogen surfaces playing an important role in their recognition. Mannose Receptors act as endocytic receptors aiding in the internalization and degradation of pathogens.
Biological function summary

The Mannose Receptor functions in pathogen recognition and clearance by binding to specific carbohydrates on the pathogen's surface. It is not part of a larger molecular complex but works independently to facilitate phagocytosis. The receptor is essential in immune responses allowing macrophages and dendritic cells to efficiently capture and process antigens for presentation to T cells. This enables the initiation of adaptive immune responses.

Pathways

Researchers know that the Mannose Receptor plays an important role in immune signaling pathways particularly in antigen processing and presentation. It interacts with proteins involved in these pathways including those necessary for the internalization and degradation of bound antigens. Moreover it works alongside scavenger receptors contributing to the regulation of immune and inflammatory responses.

The Mannose Receptor is often linked to pulmonary tuberculosis and certain types of cancer. When macrophages express this receptor it can modulate immune responses against Mycobacterium tuberculosis by aiding in its recognition. In cancer altered expression of CD206 can indicate tumor-associated macrophages which promote tumor growth by suppressing immune responses. These connections highlight the receptor's potential as a diagnostic marker and therapeutic target.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.. (Microbial infection) Acts as a phagocytic receptor for bacteria, fungi and other pathogens.. (Microbial infection) Acts as a receptor for Dengue virus envelope protein E.. (Microbial infection) Interacts with Hepatitis B virus envelope protein.
See full target information MRC1
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Translational cancer research 14:78-92 PubMed39974426

2025

METTL3 stabilizes SERPINE2 via the m6A modification to drive the malignant progression of gastric signet ring cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Tan Yan,Qian Wang,Yuhui Liu

Cell biology and toxicology 41:23 PubMed39775116

2025

Exosomal NEDD4L derived from HG+oxLDL-induced vascular endothelial cells accelerates macrophage M1 polarization and oxLDL uptake by ubiquitinating IκBα and PPARγ.

Applications

Unspecified application

Species

Unspecified reactive species

Guozhu Chen,Yisong Pei,Peng Jiang,Qiaoling Ye,Zulong Xie,Laxman Gyawali

Thoracic cancer 16:e15485 PubMed39552193

2024

USP8-mediated PTK7 promotes PIK3CB-related pathway to accelerate the malignant progression of non-small cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Wencui Kong,Xuegang Feng,Zongyang Yu,Xingfeng Qi,Zhongquan Zhao

Journal of immunology research 2024:5562293 PubMed39493373

2024

Exercise Attenuates Doxorubicin-Induced Myocardial Injury by Inhibiting TSHR and Regulating Macrophage Polarization Through miR-30d-5p/GALNT7.

Applications

Unspecified application

Species

Unspecified reactive species

Haiyan Wu,Ruoyu Zhou,Hanxin Kong,Jieqiong Yang,Suijuan Liu,Xiaolin Wei,Kunzhi Li,Yunmei Zhang

PeerJ 12:e17106 PubMed38646478

2024

S100A8/9 modulates perturbation and glycolysis of macrophages in allergic asthma mice.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyi Ji,Chunhua Nie,Yuan Yao,Yu Ma,Huafei Huang,Chuangli Hao

Frontiers in oncology 12:904969 PubMed35978822

2022

Cyclic adenosine monophosphate/phosphodiesterase 4 pathway associated with immune infiltration and PD-L1 expression in lung adenocarcinoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ling Tong,Minjie Shan,Wen Zou,XianLing Liu,Dean W Felsher,Jingjing Wang
View all publications
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