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AB275954

PE Anti-Cyclin D1 antibody [DCS-6]

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(1 Publication)

Mouse Monoclonal Cyclin D1 antibody - conjugated to PE. Suitable for Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CCND1.

View Alternative Names

BCL1, PRAD1, CCND1, G1/S-specific cyclin-D1, B-cell lymphoma 1 protein, BCL-1 oncogene, PRAD1 oncogene, BCL-1

2 Images
Flow Cytometry (Intracellular) - PE Anti-Cyclin D1 antibody [DCS-6] (AB275954)
  • Flow Cyt (Intra)

Unknown

Flow Cytometry (Intracellular) - PE Anti-Cyclin D1 antibody [DCS-6] (AB275954)

Flow cytometry intracellular staining pattern of HUVEC cells stained using ab275954 (concentration in sample 15 g/ml).

Flow Cytometry (Intracellular) - PE Anti-Cyclin D1 antibody [DCS-6] (AB275954)
  • Flow Cyt (Intra)

Unknown

Flow Cytometry (Intracellular) - PE Anti-Cyclin D1 antibody [DCS-6] (AB275954)

Separation of HUVEC cells stained using ab275954 (concentration in sample 15 g/ml, red-filled) from HUVEC cells stained using mouse IgG2a isotype control antibody (concentration in sample 15 g/ml, black-dashed) in Intracellular Flow Cytometry analysis (intracellular staining) of HUVEC cell suspension.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

DCS-6

Isotype

IgG2a

Conjugation

PE

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Carrier free

No

Reacts with

Human

Applications

Flow Cyt (Intra)

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CCND1.

P24385

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Complementary Products

Assay Kits

AB214571

Human Cyclin D1 ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human Cyclin D1 ELISA Kit (AB214571)

  • 0
  • 0
Primary Antibodies

AB198944

Alexa Fluor® 488 Anti-Cdk6 antibody [EPR4515]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 488 Anti-Cdk6 antibody [EPR4515] (AB198944)

  • 0
  • 0
Primary Antibodies

AB185048

Alexa Fluor® 488 Anti-Cytokeratin 7 antibody [EPR1619Y] - Cytoskeleton Marker

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 488 Anti-Cytokeratin 7 antibody [EPR1619Y] - Cytoskeleton Marker (AB185048)

  • 5
  • 2
Primary Antibodies

AB217731

Alexa Fluor® 555 Anti-Cyclin A2 antibody [EPR17351]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 555 Anti-Cyclin A2 antibody [EPR17351] (AB217731)

  • 0
  • 0
Primary Antibodies

AB210619

PE Anti-GSK3 beta antibody [Y174]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - PE Anti-GSK3 beta antibody [Y174] (AB210619)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCytIntra-species-checked": "testedAndGuaranteed", "FlowCytIntra-species-dilution-info": "15 µg/mL", "FlowCytIntra-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Size-exclusion chromatography
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Do Not Freeze|Store in the dark
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed : 1827756, PubMed : 1833066, PubMed : 19412162, PubMed : 33854235, PubMed : 8114739, PubMed : 8302605). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed : 1827756, PubMed : 1833066, PubMed : 19412162, PubMed : 8114739, PubMed : 8302605). Hypophosphorylates RB1 in early G(1) phase (PubMed : 1827756, PubMed : 1833066, PubMed : 19412162, PubMed : 8114739, PubMed : 8302605). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed : 1827756, PubMed : 1833066, PubMed : 19412162, PubMed : 8302605). Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity (PubMed : 15241418). Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed : 9106657). Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (PubMed : 16569215, PubMed : 18417529).
See full target information CCND1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 43:113866 PubMed38416638

2024

Atypical cofilin signaling drives dendritic cell migration through the extracellular matrix via nuclear deformation.

Applications

Unspecified application

Species

Unspecified reactive species

Harry Warner,Giulia Franciosa,Guus van der Borg,Britt Coenen,Felix Faas,Claire Koenig,Rinse de Boer,René Classens,Sjors Maassen,Maksim V Baranov,Shweta Mahajan,Deepti Dabral,Frans Bianchi,Niek van Hilten,Herre Jelger Risselada,Wouter H Roos,Jesper Velgaard Olsen,Laia Querol Cano,Geert van den Bogaart
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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