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AB305710

PE Anti-Cytokeratin 15 antibody [EPR1614Y]

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Rabbit Recombinant Monoclonal K1C15 antibody - conjugated to PE.

View Alternative Names

KRTB, KRT15, Cytokeratin-15, Keratin-15, CK-15, K15

  • Unconjugated

    Anti-Cytokeratin 15 antibody [EPR1614Y]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-Cykeratin 15 antibody [EPR1614Y]

  • 603 Alexa Fluor® 568

    Alexa Fluor® 568 Anti-Cytokeratin 15 antibody [EPR1614Y]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-Cytokeratin 15 antibody [EPR1614Y]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-Cytokeratin 15 antibody [EPR1614Y]

  • Carrier free

    Anti-Cytokeratin 15 antibody [EPR1614Y] - BSA and Azide free

  • 660 APC

    APC Anti-Cytokeratin 15 antibody [EPR1614Y]

  • HRP

    HRP Anti-Cytokeratin 15 antibody [EPR1614Y]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-Cytokeratin 15 antibody [EPR1614Y]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-Cytokeratin 15 antibody [EPR1614Y]

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR1614Y

Isotype

IgG

Conjugation

PE

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Carrier free

No

Applications

Target Binding Affinity, Antibody Labelling

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Product details

This conjugated primary antibody is "made to order" and it is released using a quantitative quality control method that ensures binding affinity and labelling efficiency of the conjugate. Via leveraging the power of the Lightning-Link® conjugation technology, Abcam will deliver highly consistent recombinant conjugates in <2 weeks, giving you access to an ever growing portfolio of antibody-label combinations.

For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 98% PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cytokeratin 15 often abbreviated as CK15 bsa-15 or keratin 15 is an intermediate filament protein known for its role in the structural integrity of epithelial cells. It weighs approximately 50 kilodaltons. This protein is mainly expressed in the basal layer of stratified squamous epithelia such as the epidermis and the hair follicle. CK15 is an essential part of the cytoskeleton contributing to cell shape and mechanical resilience.
Biological function summary

CK15 plays a significant role in maintaining epithelial stem cell populations. It is part of the keratin protein family where it forms a complex network with other cytokeratins to support epithelial cell stability. CK15 has been shown to mark epithelial progenitor cells hinting at its role in tissue regeneration and repair. Its expression levels often reflect the cellular origin and differentiation state particularly in the skin and associated structures.

Pathways

CK15 is involved in pathways related to epithelial cell differentiation and homeostasis. It interacts within the cytoskeletal network alongside other cytokeratins like keratin 5. CK15 contributes to pathways that regulate cell proliferation and differentiation. It participates in the wound healing process where keratin 6 and keratin 17 also play important roles. This involvement allows it to impact how epithelial cells respond to and repair after damage.

CK15 has been associated with skin disorders and certain types of cancers. Its expression is often altered in squamous cell carcinoma and basal cell carcinoma where abnormal CK15 levels can influence tumor behavior. Additionally changes in CK15 expression are linked to alopecia relating it to proteins like keratin 5 and keratin 8 which have similar expression patterns in hair follicles. Understanding CK15's role may aid in developing biomarkers for diagnosis and therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information KRT15
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

Select an associated product type
Alternative Version
Primary Antibodies

AB239850

Anti-Cytokeratin 15 antibody [EPR1614Y] - BSA and Azide free

primary-antibodies

cytokeratin-15-antibody-epr1614y-bsa-and-azide-free-ab239850

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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