Rabbit Recombinant Monoclonal DESP antibody - conjugated to PE.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application Antibody Labelling | Reactivity Expected | Dilution info - | Notes - |
Application Target Binding Affinity | Reactivity Expected | Dilution info - | Notes - |
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Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity).
Desmoplakin, DP, 250/210 kDa paraneoplastic pemphigus antigen, DSP
Rabbit Recombinant Monoclonal DESP antibody - conjugated to PE.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA
This conjugated primary antibody is “made to order” and it is released using a quantitative quality control method that ensures binding affinity and labelling efficiency of the conjugate. Via leveraging the power of the Lightning-Link® conjugation technology, Abcam will deliver highly consistent recombinant conjugates in <2 weeks, giving you access to an ever growing portfolio of antibody-label combinations.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.
This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for the Abcam trial program.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
Desmoplakin is a protein that plays an integral role in linking intermediate filaments to desmosomal plaques. This protein is also known by its alternate name "DSP" and has a molecular mass of approximately 332 kDa. Desmoplakin is expressed in tissues where mechanical strength is necessary such as the heart and skin. Its expression ensures structural integrity and resilience in areas that experience substantial mechanical stress.
Desmoplakin acts to maintain cell-cell adhesion through its involvement with desmosomes and is an essential component of the desmosomal complex. This complex is important for the architectural stability of epithelial and cardiac tissues. Desmoplakin interacts directly with other desmosomal proteins like plakoglobin and plakophilin forming a bridge between the cell membrane and the cytoskeleton.
Desmoplakin is an important player in the maintenance and function of the cytoskeletal network particularly within the intermediate filament organization. In addition desmoplakin participates in cellular adhesion signaling pathways. Its interaction with proteins such as plakoglobin mediates the organization of desmosomes influencing cellular signaling and communication processes critical for tissue morphogenesis and repair.
Mutations or malfunctions of desmoplakin are linked to conditions like arrhythmogenic right ventricular cardiomyopathy (ARVC) and skin disorders such as striate palmoplantar keratoderma. In these diseases desmoplakin's ability to maintain structural integrity is compromised leading to the disruption of tissue architecture. In ARVC for example the faulty interaction between desmoplakin and plakoglobin may cause abnormal heart muscle function contributing to the pathology of the disease.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com