Mouse Monoclonal DR3/LARD antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TNFRSF25.
IgG1
Mouse
PE
Ex: 480;565nm, Em: 578nm
pH: 7.4
Preservative: 0.0975% Sodium azide
Constituents: PBS
Liquid
Monoclonal
Flow Cyt | |
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Human | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 10 µL for 106 Cells | Notes - |
Select an associated product type
Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
APO3, DDR3, DR3, TNFRSF12, WSL, WSL1, UNQ455/PRO779, UNQ455/PRO779, TNFRSF12, WSL1, WSL, DR3, DDR3, APO3, TNFRSF25, Tumor necrosis factor receptor superfamily member 25, Apo-3, Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor DR3, Apoptosis-mediating receptor TRAMP, Death receptor 3, Lymphocyte-associated receptor of death, Protein WSL, Protein WSL-1, LARD
Mouse Monoclonal DR3/LARD antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TNFRSF25.
IgG1
Mouse
PE
Ex: 480;565nm, Em: 578nm
pH: 7.4
Preservative: 0.0975% Sodium azide
Constituents: PBS
Liquid
Monoclonal
JD3
Size-exclusion chromatography
ab234231 is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
Blue Ice
+4°C
+4°C
Store in the dark
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This supplementary information is collated from multiple sources and compiled automatically.
The DR3 receptor also known as LARD (Lymphocyte Apoptosis-Related Receptor Domain) is a member of the TNF receptor superfamily. This protein also referred to as the DR3 protein or LARD protein is involved in mediating apoptotic signals. DR3 is expressed predominantly in lymphoid tissues and plays an important role in immune system regulation. DR3 protein has an approximate mass of 65 kDa. Scientists study DR3 in various models including cyno RNA and protein monkey models to gain better understanding of its function and expression.
DR3 functions significantly in the immune response by modulating apoptosis. It forms part of a complex with other proteins leading to the activation of signaling pathways that result in cell death. The binding of its ligand TL1A to DR3 initiates a series of downstream effects that influence T-cell and other immune cell activities. LARD target has a functional correlation with the regulation of immune response and the maintenance of homeostasis in immune cell populations.
DR3 receptor mediates signals primarily in two significant pathways: the NF-kB pathway and the MAPK pathway. These pathways play a role in transducing signals that lead to inflammation and immune responses. DR3 interacts with other proteins such as TRADD and RIPK1 facilitating the propagation of signals through these pathways. The engagement of DR3 in these pathways highlights its regulatory influence over immune cell survival and function.
DR3 plays an important role in autoimmune diseases and inflammatory disorders. Dysregulation of DR3 receptor and its signaling pathways can contribute to conditions like rheumatoid arthritis and inflammatory bowel disease. There is a notable connection between dysfunction in DR3 signaling and altered interactions with pro-inflammatory proteins such as TNF-alpha which can exacerbate these conditions. Understanding DR3's role helps in developing therapeutic approaches to manage these disorders.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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Terms & Conditions.
Flow Cytometry analysis of DR3/LARD-transfected (red) and non-transfected HEK-293 (human epithelial cell line from embryonic kidney) (black) cells labeling DR3/LARD with ab234231. Surface staining.
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