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AB234231

PE Anti-DR3/LARD antibody [JD3]

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(1 Publication)

Mouse Monoclonal DR3/LARD antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TNFRSF25.

View Alternative Names

APO3, DDR3, DR3, TNFRSF12, WSL, WSL1, UNQ455/PRO779, TNFRSF25, Tumor necrosis factor receptor superfamily member 25, Apo-3, Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor DR3, Apoptosis-mediating receptor TRAMP, Death receptor 3, Lymphocyte-associated receptor of death, Protein WSL, Protein WSL-1, LARD

1 Images
Flow Cytometry - PE Anti-DR3/LARD antibody [JD3] (AB234231)
  • Flow Cyt

Supplier Data

Flow Cytometry - PE Anti-DR3/LARD antibody [JD3] (AB234231)

Flow Cytometry analysis of DR3/LARD-transfected (red) and non-transfected HEK-293 (human epithelial cell line from embryonic kidney) (black) cells labeling DR3/LARD with ab234231. Surface staining.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

JD3

Isotype

IgG1

Conjugation

PE

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Recombinant Full Length Protein corresponding to Human TNFRSF25. The exact immunogen used to generate this antibody is proprietary information.

Q93038

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Size-exclusion chromatography
Purification notes
ab234231 is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
Storage buffer
pH: 7.4 Preservative: 0.0975% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The DR3 receptor also known as LARD (Lymphocyte Apoptosis-Related Receptor Domain) is a member of the TNF receptor superfamily. This protein also referred to as the DR3 protein or LARD protein is involved in mediating apoptotic signals. DR3 is expressed predominantly in lymphoid tissues and plays an important role in immune system regulation. DR3 protein has an approximate mass of 65 kDa. Scientists study DR3 in various models including cyno RNA and protein monkey models to gain better understanding of its function and expression.
Biological function summary

DR3 functions significantly in the immune response by modulating apoptosis. It forms part of a complex with other proteins leading to the activation of signaling pathways that result in cell death. The binding of its ligand TL1A to DR3 initiates a series of downstream effects that influence T-cell and other immune cell activities. LARD target has a functional correlation with the regulation of immune response and the maintenance of homeostasis in immune cell populations.

Pathways

DR3 receptor mediates signals primarily in two significant pathways: the NF-kB pathway and the MAPK pathway. These pathways play a role in transducing signals that lead to inflammation and immune responses. DR3 interacts with other proteins such as TRADD and RIPK1 facilitating the propagation of signals through these pathways. The engagement of DR3 in these pathways highlights its regulatory influence over immune cell survival and function.

DR3 plays an important role in autoimmune diseases and inflammatory disorders. Dysregulation of DR3 receptor and its signaling pathways can contribute to conditions like rheumatoid arthritis and inflammatory bowel disease. There is a notable connection between dysfunction in DR3 signaling and altered interactions with pro-inflammatory proteins such as TNF-alpha which can exacerbate these conditions. Understanding DR3's role helps in developing therapeutic approaches to manage these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
See full target information TNFRSF25
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell biology and toxicology 41:23 PubMed39775116

2025

Exosomal NEDD4L derived from HG+oxLDL-induced vascular endothelial cells accelerates macrophage M1 polarization and oxLDL uptake by ubiquitinating IκBα and PPARγ.

Applications

Unspecified application

Species

Unspecified reactive species

Guozhu Chen,Yisong Pei,Peng Jiang,Qiaoling Ye,Zulong Xie,Laxman Gyawali
View all publications
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Product promise

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