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Mouse Monoclonal DR3/LARD antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TNFRSF25.

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Images

Flow Cytometry - PE Anti-DR3/LARD antibody [JD3] (AB234231), expandable thumbnail

Key facts

Isotype

IgG1

Host species

Mouse

Conjugation

PE

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Storage buffer

pH: 7.4
Preservative: 0.0975% Sodium azide
Constituents: PBS

Form

Liquid

Clonality

Monoclonal

Immunogen

  • Recombinant Full Length Protein corresponding to Human TNFRSF25. The exact immunogen used to generate this antibody is proprietary information. Database link Q93038

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
Flow Cyt
Human
Tested

Tested
Tested

Species

Human

Dilution info

10 µL for 106 Cells

Notes

-

Associated Products

Select an associated product type

2 products for Alternative Product

Target data

Function

Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.

Alternative names

Recommended products

Mouse Monoclonal DR3/LARD antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TNFRSF25.

Key facts

Isotype

IgG1

Conjugation

PE

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Form

Liquid

Clonality

Monoclonal

Immunogen
  • Recombinant Full Length Protein corresponding to Human TNFRSF25. The exact immunogen used to generate this antibody is proprietary information. Database link Q93038
Clone number

JD3

Purification technique

Size-exclusion chromatography

Concentration
Loading...
Purification notes

ab234231 is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Storage information

Store in the dark

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The DR3 receptor also known as LARD (Lymphocyte Apoptosis-Related Receptor Domain) is a member of the TNF receptor superfamily. This protein also referred to as the DR3 protein or LARD protein is involved in mediating apoptotic signals. DR3 is expressed predominantly in lymphoid tissues and plays an important role in immune system regulation. DR3 protein has an approximate mass of 65 kDa. Scientists study DR3 in various models including cyno RNA and protein monkey models to gain better understanding of its function and expression.

Biological function summary

DR3 functions significantly in the immune response by modulating apoptosis. It forms part of a complex with other proteins leading to the activation of signaling pathways that result in cell death. The binding of its ligand TL1A to DR3 initiates a series of downstream effects that influence T-cell and other immune cell activities. LARD target has a functional correlation with the regulation of immune response and the maintenance of homeostasis in immune cell populations.

Pathways

DR3 receptor mediates signals primarily in two significant pathways: the NF-kB pathway and the MAPK pathway. These pathways play a role in transducing signals that lead to inflammation and immune responses. DR3 interacts with other proteins such as TRADD and RIPK1 facilitating the propagation of signals through these pathways. The engagement of DR3 in these pathways highlights its regulatory influence over immune cell survival and function.

Associated diseases and disorders

DR3 plays an important role in autoimmune diseases and inflammatory disorders. Dysregulation of DR3 receptor and its signaling pathways can contribute to conditions like rheumatoid arthritis and inflammatory bowel disease. There is a notable connection between dysfunction in DR3 signaling and altered interactions with pro-inflammatory proteins such as TNF-alpha which can exacerbate these conditions. Understanding DR3's role helps in developing therapeutic approaches to manage these disorders.

Product promise

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1 product image

  • Flow Cytometry - PE Anti-DR3/LARD antibody [JD3] (ab234231), expandable thumbnail

    Flow Cytometry - PE Anti-DR3/LARD antibody [JD3] (ab234231)

    Flow Cytometry analysis of DR3/LARD-transfected (red) and non-transfected HEK-293 (human epithelial cell line from embryonic kidney) (black) cells labeling DR3/LARD with ab234231. Surface staining.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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