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AB205541

PE Anti-Estrogen Receptor beta antibody [ERb455]

0

(1 Review)

|

(2 Publications)

Mouse Monoclonal ESR2 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ESR2.

View Alternative Names

ESTRB, NR3A2, ESR2, Estrogen receptor beta, ER-beta, Nuclear receptor subfamily 3 group A member 2

1 Images
Flow Cytometry - PE Anti-Estrogen Receptor beta antibody [ERb455] (AB205541)
  • Flow Cyt

Supplier Data

Flow Cytometry - PE Anti-Estrogen Receptor beta antibody [ERb455] (AB205541)

Flow cytometry analysis of MCF-7 cells labeling Estrogen Receptor beta using ab205541 at 5 μL for 106 cells (Red). Black : Cells alone; Green : Isotype control.

  • Unconjugated

    Anti-Estrogen Receptor beta 1 antibody [ERb455] - C-terminal

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

ERb455

Isotype

IgG2a

Conjugation

PE

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Recombinant Fragment Protein within Human ESR2. The exact immunogen used to generate this antibody is proprietary information.

Q92731

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Alternative Products

Primary Antibodies

AB62257

Anti-Estrogen Receptor beta (phospho S105) antibody

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Primary Antibodies

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Anti-Estrogen Receptor beta antibody

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Complementary Products

Assay Kits

AB285292

Human Estrogen Receptor beta ELISA Kit

Sandwich ELISA - Human Estrogen Receptor beta ELISA Kit (AB285292)

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Primary Antibodies

AB307466

Alexa Fluor® 647 Anti-p53 (acetyl K382) antibody [EPR358(2)]

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  • 0
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Primary Antibodies

AB225510

Alexa Fluor® 647 Anti-ErbB2 / HER2 antibody [EPR19547-12]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 647 Anti-ErbB2 / HER2 antibody [EPR19547-12] (AB225510)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Primary Antibodies

AB194195

Alexa Fluor® 647 Anti-Androgen Receptor antibody [EPR1535(2)]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 647 Anti-Androgen Receptor antibody [EPR1535(2)] (AB194195)

  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "5 µL for 10^6 Cells", "FlowCyt-species-notes": "<p>or 5 μL per 100 μL of whole blood</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Purification notes
Purified from Bioreactor concentrate.
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Estrogen Receptor beta (ERβ) also known as ERbeta or beta receptor is an important nuclear receptor involved in mediating the effects of estrogens such as estradiol. This receptor with a molecular weight of approximately 59 kDa resides mainly in endothelial and epithelial tissues and can also be present in the central nervous system. ERβ possesses the ability to bind ligands and translocate to the nucleus where it regulates the transcription of specific target genes.
Biological function summary

Estrogen Receptor beta plays a significant role in cell growth regulation and differentiation. It often forms dimers with Estrogen Receptor alpha (ERα) contributing to the diversity of estrogen signaling responses. As part of the nuclear receptor family ERβ engages in binding with DNA at estrogen response elements influencing various physiological processes. The presence of ERβ in tissues implies it has a potentially protective role possibly balancing the actions of ERα.

Pathways

Estrogen Receptor beta plays an essential role in the estrogen signaling pathway and the apoptosis pathway. Interaction with ERα can influence pathways related to cell proliferation and survival contributing to distinct physiological outcomes. ERβ's involvement with proteins like the retinoic acid receptor within these pathways highlights its impact on controlling gene expression important for cell cycle regulation and programmed cell death.

Estrogen Receptor beta has implications in cancers and cardiovascular diseases. In breast cancer ERβ may act differently from ERα possibly providing protective effects against tumor growth. Moreover the receptor's expression affects cardiovascular health by modulating inflammation and vascular function. ERβ interacts with proteins such as p53 hinting at its role in controlling cellular stress responses and combating oncogenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed : 20074560).. Isoform 2. Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.
See full target information ESR2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

iScience 28:112649 PubMed40502701

2025

Central role of regular firing neurons of centrolateral amygdala in affective behaviors.

Applications

Unspecified application

Species

Unspecified reactive species

Alvaro García,M Isabel Aller,Ana V Paternain,Juan Lerma

Cells 11: PubMed35011679

2021

MFUM-BrTNBC-1, a Newly Established Patient-Derived Triple-Negative Breast Cancer Cell Line: Molecular Characterisation, Genetic Stability, and Comprehensive Comparison with Commercial Breast Cancer Cell Lines.

Applications

Unspecified application

Species

Unspecified reactive species

Kristijan Skok,Lidija Gradišnik,Helena Čelešnik,Marko Milojević,Uroš Potočnik,Gregor Jezernik,Mario Gorenjak,Monika Sobočan,Iztok Takač,Rajko Kavalar,Uroš Maver
View all publications
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Product promise

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