Rat Monoclonal F4/80 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 9 publications. Immunogen corresponding to Cell preparation containing Adgre1 protein.
IgG2b
Rat
PE
Ex: 480;565nm, Em: 578nm
pH: 7.4
Preservative: 0.09% Sodium azide
Constituents: PBS, 5% Sucrose, 1% BSA
Liquid
Monoclonal
Flow Cyt | |
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Mouse | Tested |
Species | Dilution info | Notes |
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Species Mouse | Dilution info 10 µL for 106 Cells | Notes in 100 μl. ab136585 - Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody. |
Select an associated product type
Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development.
Emr1, Gpf480, Adgre1, Adhesion G protein-coupled receptor E1, Cell surface glycoprotein F4/80, EGF-like module receptor 1, EGF-like module-containing mucin-like hormone receptor-like 1, EMR1 hormone receptor
Rat Monoclonal F4/80 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 9 publications. Immunogen corresponding to Cell preparation containing Adgre1 protein.
IgG2b
Rat
PE
Ex: 480;565nm, Em: 578nm
pH: 7.4
Preservative: 0.09% Sodium azide
Constituents: PBS, 5% Sucrose, 1% BSA
Liquid
Monoclonal
CI:A3-1
Affinity purification Protein A
ab105156 recognises the murine F4/80 antigen.
Blue Ice
+4°C
+4°C
Clone CI:A3-1 has been reported to modulate cytokine levels released in response to Listeria monocytogenes.
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This supplementary information is collated from multiple sources and compiled automatically.
F4/80 also known as Emr1 (Epidermal growth factor module-containing mucin-like hormone receptor 1) is a well-characterized surface protein with a mass of approximately 160 kDa. This protein is recognized as a marker for murine macrophages. F4/80 is heavily expressed on cells of the monocyte and macrophage lineage particularly in tissue-resident macrophages found in organs like the liver spleen and lung. Its expression is vital for identifying macrophages in various types of immunological studies including F4/80 staining and macrophage marker analysis.
F4/80 plays a role in modulating the immune response by interacting with other cell surface molecules. While not part of a larger protein complex F4/80 influences macrophage functions such as phagocytosis and cytokine production. Its expression contributes to the regulation of tissue homeostasis and inflammation. The protein is critical in maintaining the macrophage population required for reliable immune surveillance and response to pathogens.
F4/80 is an integral part of the immunological and inflammatory signaling pathways. It interacts with TLRs (Toll-like receptors) and other cell surface molecules that sense microbial components therefore helping in the initiation of innate immune responses. F4/80 is connected to proteins like cytokine receptors which play roles in mediating and resolving inflammatory signals important for maintaining balanced immune activity.
F4/80 is associated with conditions like chronic inflammation and autoimmune disorders. Its expression levels can often correlate with disease state impacting diseases such as rheumatoid arthritis and liver fibrosis. In these conditions F4/80 interacts with proteins like TNF-alpha and IL-1beta which are involved in inflammatory processes. Understanding F4/80's role can help uncover therapeutic targets aimed at modulating macrophage functions to treat these disorders effectively.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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Flow cytometry staining of mouse J774 cells with ab105156.
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