Rabbit Recombinant Monoclonal IL1 Receptor I/IL-1R-1 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Il1r1.
Images
![Flow Cytometry - PE Anti-IL1 Receptor I/IL-1R-1 antibody [191] (AB279600), expandable thumbnail](https://content.abcam.com/products/images/pe-il1-receptor-i-il-1r-1-antibody-191-ab279600--flow-cytometry-img14327.jpg/_jcr_content/renditions/webp-475.webp "Flow Cytometry - PE Anti-IL1 Receptor I/IL-1R-1 antibody [191] (AB279600)")
Publications
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- Disease models & mechanisms 15:2022Bortezomib-induced neurotoxicity in human neurons is the consequence of nicotinamide adenine dinucleotide depletion.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAndrew R Snavely,Keungjung Heo,Veselina Petrova,Tammy Szu-Yu Ho,Xuan Huang,Crystal Hermawan,Ruth Kagan,Tao Deng,Ilyas Singeç,Long Chen,Lee B Barret,Clifford J WoolfPubMed 36398590
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Conjugation
- PE
- Excitation/Emission
- Ex: 480;565nm, Em: 578nm
- Storage buffer
Preservative: 0.09% Sodium azide
Constituents: 99.41% Deionized Water (H20), 0.5% BSA- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- Recombinant Full Length Protein corresponding to Mouse Il1r1. Database link P13504
Reactivity data
Select an application| Flow Cyt | |
|---|---|
| Mouse | Tested |
Flow Cyt
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes Concentration: 10 μl/Test, 0.1 mg/ml |
Target data
Function
Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity). Isoform 2. Unable to mediate canonical IL-1 signaling. Cooperates with IL1RAP isoform 3 to mediate IL1B-induced neuronal activity including IL1B-potentiated NMDA-induced calcium influx mediated by Akt kinase activation.
Alternative names
CD121a, Il-1r1, Il1ra, Il1r1, Interleukin-1 receptor type 1, IL-1R-1, IL-1RT-1, IL-1RT1, CD121 antigen-like family member A, Interleukin-1 receptor alpha, Interleukin-1 receptor type I, p80, IL-1R-alpha
Recommended products
Rabbit Recombinant Monoclonal IL1 Receptor I/IL-1R-1 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Il1r1.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Conjugation
- PE
- Excitation/Emission
- Ex: 480;565nm, Em: 578nm
- Storage buffer
Preservative: 0.09% Sodium azide
Constituents: 99.41% Deionized Water (H20), 0.5% BSA- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- Recombinant Full Length Protein corresponding to Mouse Il1r1. Database link P13504
- Clone number
- 191
- Purification technique
- Affinity purification Protein A
- Specificity
Mouse IL-1R1 / CD121a
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Do Not Freeze, Store in the dark
Notes
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free batch production
For more information, read more on recombinant antibodies.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The IL-1 Receptor I also known as IL-1R1 is a transmembrane protein with alternative names such as IL-1 receptor and IL-1 type I receptor. It acts as an important receptor for the pro-inflammatory cytokine Interleukin-1 (IL-1) family primarily IL-1α and IL-1β. IL-1R1 has a mass of approximately 80 kilodaltons and is expressed in a variety of cell types including endothelial cells epithelial cells and fibroblasts. It is also present on immune cells like monocytes and macrophages making it widespread in a vast range of tissues.
- Biological function summary
IL-1R1 is a critical player in the initiation of immune responses serving as a component of the IL-1 signaling complex. When IL-1 binds to IL-1R1 it recruits the IL-1 receptor accessory protein (IL-1RAcP) to form a signaling complex that triggers downstream pathways. This interaction initiates a signaling cascade that activates nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs) promoting the expression of inflammatory genes and mediating immune and inflammatory responses.
- Pathways
IL-1R1 is central to the inflammatory response and immune signaling pathways. The IL-1 receptor complex facilitates the activation of NF-κB which plays a role in the body's response to stress cytokines and pathogens. The receptor acts in close relation with other proteins like IL-1RAcP and IRAKs (Interleukin-1 receptor-associated kinases) in these pathways creating a robust immune signaling network that drives the inflammatory response.
- Associated diseases and disorders
IL-1R1 is closely associated with inflammatory conditions such as rheumatoid arthritis and inflammatory bowel disease. Increased IL-1R1 expression and signaling contribute to chronic inflammation in these diseases. The interaction of IL-1β with IL-1R1 and subsequently with proteins like NF-κB leads to the persistence of inflammatory signals. Moreover targeting IL-1R1 and related proteins offers potential therapeutic strategies in mitigating the symptoms and progression of inflammatory disorders.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
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1 product image
![Flow Cytometry - PE Anti-IL1 Receptor I/IL-1R-1 antibody [191] (ab279600), expandable thumbnail](https://content.abcam.com/products/images/pe-il1-receptor-i-il-1r-1-antibody-191-ab279600--flow-cytometry-img14327.jpg "Flow Cytometry - PE Anti-IL1 Receptor I/IL-1R-1 antibody [191] (ab279600)")
Flow Cytometry - PE Anti-IL1 Receptor I/IL-1R-1 antibody [191] (ab279600)
Flow cytometric analysis of Mouse IL1R1(CD121a) expression on NIH/3T3 cells. Cells were stained with ab279600 (Black peak) along with an isotype control (grey peak). The histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
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