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AB230663

PE Anti-ILT-7 antibody [17G10.2]

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(1 Publication)

Mouse Monoclonal ILT-7 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples. Cited in 1 publication.

View Alternative Names

CD85g, ILT7, LILRA4, Leukocyte immunoglobulin-like receptor subfamily A member 4, CD85 antigen-like family member G, Immunoglobulin-like transcript 7, ILT-7

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Flow Cytometry - PE Anti-ILT-7 antibody [17G10.2] (AB230663)
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Supplier Data

Flow Cytometry - PE Anti-ILT-7 antibody [17G10.2] (AB230663)

Flow cytometric of human peripheral blood labeling ILT-7 with ab230663.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

17G10.2

Isotype

IgG1

Conjugation

PE

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "10 µL for 10^6 Cells", "FlowCyt-species-notes": "<p>(or 100 μl of whole blood).</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Size-exclusion chromatography
Purification notes
Purified from TCS. Purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
Storage buffer
pH: 7.4 Preservative: 0.0975% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ILT-7 also known as LILRA4 is an important receptor involved in the immune response. It is expressed on plasmacytoid dendritic cells and holds significant weight approximately 38 kDa. The receptor is part of the immunoglobulin-like transcript family containing unique extracellular domains that interact with specific ligands. ILT-7 is known for its role in mediating signals that shape the behavior of immune cells particularly in antiviral defenses.
Biological function summary

ILT-7 plays an important role in the regulation of type I interferon production in dendritic cells. This receptor forms a complex with the Fc epsilon RI gamma chain which transmits activation signals inside the cell. In resting conditions ILT-7 helps maintain immune homeostasis by regulating the release of interferons therefore balancing immune activation and controlling potential overactivity that might lead to autoimmunity.

Pathways

ILT-7 interacts within the signaling network of toll-like receptor (TLR) pathways. It closely ties with TLR9 a protein that recognizes unmethylated CpG motifs often found in viral DNA enhancing the production of interferons during viral infections. This collaboration establishes a link between pathogen recognition and immune response modulation within dendritic cells assisting in orchestrating a potent defense against viral pathogens.

ILT-7 has connections to systemic lupus erythematosus and chronic viral infections. Dysregulation of ILT-7 expression or function can lead to excessive interferon production contributing to the pathology of lupus. In chronic viral infections ILT-7 interaction with proteins like TLR9 and the subsequent dysregulation can support viral persistence or worsen disease outcomes by altering immune responses. Understanding ILT-7’s roles offers insights into therapeutic targets for modulating immune response in these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed : 16735691, PubMed : 19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as a negative regulator of TLR7 and TLR9 signaling cascades (PubMed : 16735691, PubMed : 19564354, PubMed : 24586760). Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed : 26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed : 16735691, PubMed : 19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PubMed : 24586760).
See full target information LILRA4
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell transplantation 30:9636897211033275 PubMed34338573

2021

CTRP13 Protects H9c2 Cells Against Hypoxia/Reoxygenation (H/R)-Induced Injury Via Regulating the AMPK/Nrf2/ARE Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Weifeng Jiang,Jungang Song,Suitao Zhang,Yanyan Ye,Jun Wang,Yilin Zhang
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