PE Anti-Integrin beta 3 antibody [HM beta 3.1]

Target data

Integrin alpha-V/beta-3 (ITGAV : ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 (ITGA2B : ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surfaces. Fibrinogen binding enhances SELP expression in activated platelets (PubMed : 19332769). ITGAV : ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV : ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV : ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV : ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (By similarity). ITGAV : ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (By similarity). ITGAV : ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (By similarity). ITGAV : ITGB3 binds to IL1B and this binding is essential for IL1B signaling (By similarity). ITGAV : ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (By similarity). ITGAV : ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). ITGAV : ITGB3 binds to the Lilrb4a/Gp49b receptor and enhances the Lilrb4a-mediated inhibition of mast cell activation (PubMed : 11323698). ITGAV : ITGB3 also suppresses marginal zone B cell antibody production through its interaction with Lilrb4a (PubMed : 24935931). In brain, plays a role in synaptic transmission and plasticity (PubMed : 18549786, PubMed : 29038237). Involved in the regulation of the serotonin neurotransmission, is required to localize to specific compartments within the synapse the serotonin receptor SLC6A4 and for an appropriate reuptake of serotonin (PubMed : 29038237). Controls excitatory synaptic strength by regulating GRIA2-containing AMPAR endocytosis, which affects AMPAR abundance and composition (PubMed : 18549786). ITGAV : ITGB3 act as a receptor for CD40LG (By similarity). ITGAV : ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP (By similarity).