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AB288663

PE Anti-LAR antibody [W7C6]

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Mouse Monoclonal LAR antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples.

View Alternative Names

LAR, PTPRF, Receptor-type tyrosine-protein phosphatase F, Leukocyte common antigen related

1 Images
Flow Cytometry - PE Anti-LAR antibody [W7C6] (AB288663)
  • Flow Cyt

Supplier Data

Flow Cytometry - PE Anti-LAR antibody [W7C6] (AB288663)

Separation of HeLa cells stained using ab288663 (concentration in sample 0.5 μg/ml, red-filled) from HeLa cells stained using mouse IgG1 isotype control PE antibody (concentration in sample 0.5 μg/ml, black-dashed) in flow cytometry analysis (surface staining) of HeLa cell suspension.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

W7C6

Isotype

IgG1

Conjugation

PE

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

Specificity

The mouse monoclonal antibody W7C6 recognizes an extracellular epitope of protein tyrosine phosphatase LAR, a marker of mesenchymal stem cells.

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Complementary Products

Cell Lines & Lysates

AB266585

Human PTPRF (LAR) knockout HEK-293T cell line

Sanger Sequencing - Human PTPRF (LAR) knockout HEK-293T cell line (AB266585)

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Cell Lines & Lysates

AB263319

Human PTPRF (LAR) knockout HEK-293T cell lysate

Sanger Sequencing - Human PTPRF (LAR) knockout HEK-293T cell lysate (AB263319)

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  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "2-5 g/mL", "FlowCyt-species-notes": "<p></p>" }, "Primates": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Size-exclusion chromatography
Storage buffer
pH: 7.4 Preservative: 0.098% Sodium azide Constituents: PBS, 0.2% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein LAR also known as Leukocyte Common Antigen-Related phosphatase is a receptor-like protein tyrosine phosphatase. It weighs approximately 220 kDa. LAR is expressed in various tissues including the nervous system and digestive tract. It comprises an extracellular domain a single transmembrane domain and two intracellular phosphatase domains which play a significant role in its interaction with other proteins.
Biological function summary

This receptor-like phosphatase supports important cell signaling functions. LAR is involved in neural development processes and is part of the synaptic adhesion complex. By interacting with proteins in the plasma membrane it helps modify and maintain neural connectivity necessary for proper nerve function. Its activity influences actin cytoskeleton dynamics and cell-cell adhesion.

Pathways

LAR plays a role in the axon guidance and insulin signaling pathways. In axon guidance it interacts with proteins such as netrin and nneural cell adhesion molecule (NCAM) to facilitate correct neural wiring. In the insulin signaling pathway LAR can dephosphorylate key proteins like insulin receptor affecting glucose metabolism and overall energy homeostasis.

Research shows that LAR may be linked to diabetes and potential neurological disorders. In diabetes its interaction with the insulin receptor suggests a role in insulin resistance which is a major contributing factor in the disease. In neurological disorders LAR’s dysregulation can affect neural development and function possibly linking it to diseases like schizophrenia where cell signaling and connectivity changes are observed.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
See full target information PTPRF
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Product promise

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