Mouse Monoclonal M6PR (cation independent) antibody - conjugated to PE. Suitable for Flow Cyt, Flow Cyt (Intra) and reacts with Human samples. Immunogen corresponding to Virus preparation containing IGF2R protein.
IgG1
Mouse
PE
Ex: 480;565nm, Em: 578nm
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: PBS
Liquid
Monoclonal
Flow Cyt | Flow Cyt (Intra) | |
---|---|---|
Human | Tested | Expected |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 10 µL for 106 Cells | Notes Or 100 μL of whole blood. |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 10 µL for 106 Cells | Notes Or 100 μL of whole blood. |
Select an associated product type
Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:18817523, PubMed:2963003). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:18817523, PubMed:2963003). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005).
MPRI, IGF2R, MPRI, Cation-independent mannose-6-phosphate receptor, CI Man-6-P receptor, CI-MPR, M6PR, 300 kDa mannose 6-phosphate receptor, Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptor, M6P/IGF2 receptor, MPR 300, IGF-II receptor, M6P/IGF2R
Mouse Monoclonal M6PR (cation independent) antibody - conjugated to PE. Suitable for Flow Cyt, Flow Cyt (Intra) and reacts with Human samples. Immunogen corresponding to Virus preparation containing IGF2R protein.
IgG1
Mouse
PE
Ex: 480;565nm, Em: 578nm
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: PBS
Liquid
Monoclonal
MEM-240
Size-exclusion chromatography
ab69311 recognizes an extracellular epitope between amino acids 698-1262.
The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Blue Ice
+4°C
+4°C
Store in the dark
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This supplementary information is collated from multiple sources and compiled automatically.
The cation-independent mannose 6-phosphate receptor (M6PR) is an important player in cellular transport mechanisms. Also known as the insulin-like growth factor 2 receptor (IGF2R) this protein weighs approximately 300 kDa. M6PR is present on the membrane of lysosomes and works as a lysosome membrane marker. It functions as a sorting receptor in the Golgi apparatus and endosomes facilitating the transport of lysosomal enzymes from the Golgi to lysosomes and back for function and degradation.
The M6PR enables essential cellular processes by mediating the trafficking of enzymes important to lysosomal function. This receptor takes part in recognizing and binding proteins tagged with mannose 6-phosphate signals allowing their transport to lysosomes. IGF2R engages in forming transient complexes with these enzymes within the cellular trafficking circuitry therefore ensuring the proper delivery of enzyme cargo to its target destination.
M6PR fits importantly within lysosomal enzyme transport and the insulin-like growth factor (IGF) pathway. It partially regulates the homeostasis of IGF2 by facilitating its degradation modulating cell proliferation growth and development. Steric interactions with IGF2 and other proteins like mannose receptor homologs and IGF-binding proteins outline its influence within these pathways highlighting its multifunctionality.
M6PR connects to certain cancers and lysosomal storage disorders. Dysfunctional pathway interactions or mutations within IGF2R often relate with types of cancer such as breast and liver cancers due to its influence on IGF2 regulation and cell proliferation. Additionally it associates with lysosomal storage diseases as lysosome-related pathologies emerge from impaired enzyme transport reflecting the M6PR's intricate role in cellular homeostasis.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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Flow cytometry detection of M6PR (cation independent) in human peripheral blood labeling M6PR (cation independent) with ab269311.
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