PE Anti-Macrophage antibody [BM8]

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

These versatile cells maintain homeostasis and play roles in tissue repair and inflammation. They are part of protective mechanisms of body engaging in destruction of pathogens and mediation of immune responses. Macrophages can release cytokines chemokines and other molecules that influence immune cell proliferation and differentiation. In mouse models macrophage markers like BM8 help to identify their populations and quantify their roles in various experiments.

Pathways

These immune cells participate in both the innate and adaptive immune responses. They influence the NF-kB and MAPK pathways both of which play significant roles in stress and inflammatory responses. Macrophages interact with proteins like Toll-like receptors (TLRs) to activate downstream signaling that leads to altered gene expression necessary for immune response. They serve as critical components in pathways that facilitate communication between different cell types in immune system.