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AB275642

PE Anti-Oxidative Stress Defense antibody [11]

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Mouse Monoclonal Superoxide Dismutase 1 antibody - conjugated to PE. Suitable for Flow Cyt (Intra) and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SOD1 aa 1 to C-terminus.

View Alternative Names

Superoxide dismutase [Cu-Zn], Hydrogen sulfide oxidase, Superoxide dismutase 1, hSod1, SOD1

1 Images
Flow Cytometry (Intracellular) - PE Anti-Oxidative Stress Defense antibody [11] (AB275642)
  • Flow Cyt (Intra)

Supplier Data

Flow Cytometry (Intracellular) - PE Anti-Oxidative Stress Defense antibody [11] (AB275642)

Intracellular flow cytometric analysis ofHeLa (human epithelial cell line from cervix adenocarcinoma) cells labeling Oxidative Stress Defense with ab275642 (Black) compared with isotype control (Grey).

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

11

Isotype

IgG2b

Conjugation

PE

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Carrier free

No

Reacts with

Human

Applications

Flow Cyt (Intra)

applications

Immunogen

Recombinant Fragment Protein within Human SOD1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P00441

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCytIntra-species-checked": "testedAndGuaranteed", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "<p>Use at 5 μl/Test</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.09% Sodium azide Constituents: 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Do Not Freeze|Store in the dark
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The oxidative stress defense proteins protect cells from damage induced by reactive oxygen species (ROS). These proteins including superoxide dismutase catalase and glutathione peroxidase counteract oxidative stress by neutralizing harmful ROS. Superoxide dismutase with a mass of approximately 32 kDa is expressed in the cytoplasm mitochondria and extracellular space across various tissues. Catalase and glutathione peroxidase play similar roles ensuring a balance is maintained in cellular environments prone to oxidative reactions.
Biological function summary

These proteins engage with multiple cell processes to maintain cellular health by preventing oxidative damage to DNA proteins and lipids. These defense proteins often form part of larger complexes that work synergistically to reduce oxidative stress levels. By participating in antioxidant defense they limit cellular malfunction and support normal cellular signaling and function encompassing broad cellular protective mechanisms.

Pathways

Proteins involved in oxidative stress defense play a role in the detoxification pathway reducing oxidative stress markers and maintaining cellular redox balance. The pathway involves interactions with key endogenous antioxidants like glutathione. They also intersect with inflammation-related pathways wherein oxidative stress-related damage often triggers inflammatory responses. Oxidative stress defense proteins may also interact with the nuclear factor erythroid 2-related factor 2 (Nrf2) a transcription factor important for inducing antioxidant response elements.

Oxidative stress defense proteins have connections to conditions such as neurodegenerative diseases like Alzheimer's and cardiovascular disorders. In Alzheimer's disease abnormal oxidation affects amyloid-beta proteins where oxidative stress exacerbates symptoms. Additionally oxidative stress influences pathways contributing to plaque formation in cardiovascular disease suggesting a role in disease progression. These proteins’ functions strongly tie to proteins like amyloid precursor protein in Alzheimer’s and low-density lipoprotein in cardiovascular disease emphasizing their critical role in disease pathophysiology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Destroys radicals which are normally produced within the cells and which are toxic to biological systems (PubMed : 24140062). Catalyzes the oxidation of hydrogen sulfide (H2S) to sulfate, playing an important role in detoxifying H2S and limiting the accumulation of reactive sulfur species (RSS) such as persulfides and polysulfides (PubMed : 36630448).
See full target information SOD1
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Product promise

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