Mouse Monoclonal p75 NGF Receptor antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Primates, Human, Ferret, Cat, Rabbit samples. Cited in 3 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human NGFR.
IgG1
Mouse
PE
Ex: 480;565nm, Em: 578nm
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS, 0.2% BSA
Liquid
Monoclonal
| Flow Cyt | |
|---|---|
| Human | Expected |
| Mouse | Not recommended |
| Rat | Not recommended |
| Cat | Expected |
| Ferret | Expected |
| Primates | Expected |
| Rabbit | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Primates | Dilution info 10 µL for 106 Cells | Notes 10ul per 100ul whole blood. ab91357 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
Species Human | Dilution info 10 µL for 106 Cells | Notes 10ul per 100ul whole blood. ab91357 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
Species Ferret | Dilution info 10 µL for 106 Cells | Notes 10ul per 100ul whole blood. ab91357 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
Species Cat | Dilution info 10 µL for 106 Cells | Notes 10ul per 100ul whole blood. ab91357 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
Species Rabbit | Dilution info 10 µL for 106 Cells | Notes 10ul per 100ul whole blood. ab91357 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes 10ul per 100ul whole blood. ab91357 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
Species Rat | Dilution info - | Notes 10ul per 100ul whole blood. ab91357 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
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Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138).
TNFRSF16, TNFRSF16, NGFR, Tumor necrosis factor receptor superfamily member 16, Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, Low-affinity nerve growth factor receptor p75NGFR, Low-affinity nerve growth factor receptor p75NGR, p75 ICD, NGF receptor
Mouse Monoclonal p75 NGF Receptor antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Primates, Human, Ferret, Cat, Rabbit samples. Cited in 3 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human NGFR.
IgG1
Mouse
PE
Ex: 480;565nm, Em: 578nm
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS, 0.2% BSA
Liquid
Monoclonal
NGFR5
Size-exclusion chromatography
The epitope is localized within amino acids 1-160.
Blue Ice
+4°C
+4°C
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This supplementary information is collated from multiple sources and compiled automatically.
The p75 NGF receptor also known as p75 NGFR or anti-NTR is a transmembrane protein with a molecular mass of approximately 75 kDa. It is a member of the tumor necrosis factor receptor superfamily. This receptor is widely expressed in the nervous system particularly in neurons glial cells and Schwann cells. The p75 receptor primarily binds to neurotrophins such as nerve growth factor (NGF) influencing neuronal survival apoptosis and growth.
The p75 receptor functions as an important part of a signaling complex that mediates diverse cellular responses. It often forms complexes with other receptors like TrkA but can also signal independently. In particular the p75 protein can form a biological chimera with different co-receptors influencing its downstream effects. This makes it significant in processes like apoptosis and neuronal differentiation as well as influencing neurotrophin-mediated signaling.
The p75 receptor plays an important role in pathways involving neuronal survival and apoptosis. One key pathway involves the nerve growth factor (NGF) signaling pathway where p75 collaborates with Trk receptors enhancing or inhibiting NGF signaling based on cellular context. Another pathway is the JNK signaling pathway where the p75 receptor interacts with proteins like sortilin contributing to apoptosis and stress responses in neurons. These interactions determine the outcome of neurotrophic signaling highlighting its role in cell fate decisions.
P75 receptor is associated with several neurodegenerative conditions and cancers. Its involvement in Alzheimer's disease is significant because altered p75 expression and function can contribute to neurodegeneration through apoptosis pathways. This receptor is also linked to glioblastoma where it might promote tumor progression in coordination with proteins such as sortilin. These links make p75 receptor a target of interest for therapeutic intervention in these diseases.
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