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AB93589

PE Anti-PD-L2 antibody [TY25]

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(4 Publications)

Rat Monoclonal PD-L2 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 4 publications. Immunogen corresponding to Cell preparation containing Pdcd1lg2 protein.

View Alternative Names

CD273, B7dc, Btdc, Cd273, Pdl2, Pdcd1lg2, Programmed cell death 1 ligand 2, PD-1 ligand 2, PD-L2, PDCD1 ligand 2, Programmed death ligand 2, Butyrophilin B7-DC, B7-DC

1 Images
Flow Cytometry - PE Anti-PD-L2 antibody [TY25] (AB93589)
  • Flow Cyt

Unknown

Flow Cytometry - PE Anti-PD-L2 antibody [TY25] (AB93589)

Staining of non-transfected (left) and mouse PD-L2 transfected (right) cells with 0.25μg PE Rat IgG2a isotype control (open histogram) or 0.06μg ab93589 (colored histogram). Total viable cells were used for analysis.

Key facts

Host species

Rat

Clonality

Monoclonal

Clone number

TY25

Isotype

IgG2a

Light chain type

kappa

Conjugation

PE

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Carrier free

No

Reacts with

Mouse

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing Pdcd1lg2 protein. The exact immunogen used to generate this antibody is proprietary information.

Q9WUL5

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Complementary Products

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Secondary Antibodies

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Assay Kits

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Primary Antibodies

AB209959

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Flow Cytometry - Alexa Fluor® 488 Anti-PD-L1 antibody [28-8] (AB209959)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "0.06-0.5 µg for 10^5-10^8 Cells", "FlowCyt-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.2 Preservative: 0.09% Sodium azide Constituents: PBS, 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PD-L2 also known as PDCD1LG2 or B7-DC is a member of the B7 protein family that plays a role in immune system regulation. This protein has a molecular mass of approximately 25 kDa. PD-L2 is expressed in antigen-presenting cells such as dendritic cells and macrophages. Expression is also located in some subsets of T cells and B cells. The PD-L2 can act as a second ligand for the PD-1 receptor which is important in immune checkpoints.
Biological function summary

PD-L2 offers protection to tissues from autoimmunity by regulating T-cell activation and fostering tolerance. By engaging with its receptor PD-1 PD-L2 forms a complex that modulates the immune response to prevent overactivation. This interaction limits the immune system's potential damage to healthy tissues maintaining proper immune function in diverse environments.

Pathways

PD-L2 participates in the immune checkpoint pathways where it works closely with PD-1 to mediate immune responses. PD-L2 forms an important part of the program death-1 (PD-1) pathway which plays a prominent role in downregulating T-cell activity. It relates to proteins such as PD-L1 which also interacts with PD-1 modulating immune tolerance and response to infections or tumors.

PD-L2 involvement has been significant in cancer immunology and autoimmune conditions. Its interaction with PD-1 relates to the suppression of immune responses in tumors contributing to cancer progression. PD-L2's function as an immune checkpoint ligand associates with autoimmune diseases like rheumatoid arthritis where immune regulation goes awry. Both PD-1 and PD-L2 represent potential targets for therapeutic interventions due to their roles in these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a critical role in induction and maintenance of immune tolerance to self (PubMed : 11224527, PubMed : 11283156, PubMed : 12719480, PubMed : 18641123). Acts as a ligand for the inhibitory receptor PDCD1/PD-1, inhibiting T-cell proliferation by blocking cell cycle progression and cytokine production (PubMed : 11224527, PubMed : 11283156, PubMed : 12719480, PubMed : 18641123).
See full target information Pdcd1lg2
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Journal of immunology (Baltimore, Md. : 1950) 179:5204-10 PubMed17911605

2007

PDL1 is required for peripheral transplantation tolerance and protection from chronic allograft rejection.

Applications

Unspecified application

Species

Unspecified reactive species

Katsunori Tanaka,Monica J Albin,Xueli Yuan,Kazuhiro Yamaura,Antje Habicht,Takaya Murayama,Martin Grimm,Ana Maria Waaga,Takuya Ueno,Robert F Padera,Hideo Yagita,Miyuki Azuma,Tahiro Shin,Bruce R Blazar,David M Rothstein,Mohamed H Sayegh,Nader Najafian

Journal of immunology (Baltimore, Md. : 1950) 171:4156-63 PubMed14530338

2003

Blockade of B7-H1 suppresses the development of chronic intestinal inflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Takanori Kanai,Teruji Totsuka,Koji Uraushihara,Shin Makita,Tetsuya Nakamura,Kazutaka Koganei,Tsuneo Fukushima,Hisaya Akiba,Hideo Yagita,Ko Okumura,Utako Machida,Hideyuki Iwai,Miyuki Azuma,Lieping Chen,Mamoru Watanabe

The Journal of experimental medicine 198:63-9 PubMed12847137

2003

The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice.

Applications

Unspecified application

Species

Unspecified reactive species

Mohammed Javeed I Ansari,Alan D Salama,Tanuja Chitnis,R Neal Smith,Hideo Yagita,Hisaya Akiba,Tomohide Yamazaki,Miyuki Azuma,Hideyuki Iwai,Samia J Khoury,Hugh Auchincloss,Mohamed H Sayegh

Journal of immunology (Baltimore, Md. : 1950) 169:5538-45 PubMed12421930

2002

Expression of programmed death 1 ligands by murine T cells and APC.

Applications

Unspecified application

Species

Unspecified reactive species

Tomohide Yamazaki,Hisaya Akiba,Hideyuki Iwai,Hironori Matsuda,Mami Aoki,Yuka Tanno,Tahiro Shin,Haruo Tsuchiya,Drew M Pardoll,Ko Okumura,Miyuki Azuma,Hideo Yagita
View all publications
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Product promise

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