PE Anti-PI 3 Kinase p85 alpha (phospho Y467) + PI3 Kinase p55 (phospho Y199) antibody [PI3KY458-1A11]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The PI 3 Kinase p85 alpha also known as PI3K p85 or PI3-kinase p85 is a regulatory subunit part of the phosphoinositide 3-kinases (PI3Ks) complex which is integral to cellular functions. The p85 alpha form partners with the catalytic subunit to form PI3K p55 known for its significant role in signaling. This subunit exhibits a molecular weight of approximately 85 kDa. It shows expression in various tissues including liver muscle and brain where it aids in cellular communication responding to extracellular signals.

Biological function summary

PI 3 Kinase p85 alpha plays an essential role in intracellular signaling where it functions as part of the PI3K complex. It functions to regulate metabolic processes by interacting with phosphatidylinositol lipids in the cell membrane. PI3K p55 form contributes to cell growth survival and proliferation often collaborating with the catalytic subunit p110 to execute these functions. The phospho PI3K form becomes active upon receiving external growth factors facilitating downstream signaling.

Pathways

The involvement of PI 3 Kinase p85 alpha extends to critical cellular pathways like the PI3K/AKT pathway and the insulin signaling pathway. It engages with proteins such as AKT (protein kinase B) and IRS-1 linking to various cellular functions including metabolism protein synthesis and cellular proliferation. The activity of PI3K p55 form regulates these pathways by influencing enzyme activity and pathways associated with cell survival and apoptosis.

Associated diseases and disorders

Dysregulation of PI 3 Kinase p85 alpha associates closely with cancers and metabolic disorders like type 2 diabetes. Aberrations in the p55 form link to tumorigenesis due to its role in uncontrolled cell proliferation. PI3K pathway disorders also relate to insulin resistance where the malfunction of PI3K components disrupts normal glucose uptake and insulin signaling. This target when interacting with proteins like PTEN further influences the development of cancer highlighting its critical role in both oncogenic and metabolic pathologies.