JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB190282

PE Anti-STRO1 antibody [STRO-1]

Be the first to review this product! Submit a review

|

(7 Publications)

Mouse Monoclonal STRO1 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Cell preparation containing STRO1 protein.

View Alternative Names

STRO-1

1 Images
Flow Cytometry - PE Anti-STRO1 antibody [STRO-1] (AB190282)
  • Flow Cyt

Supplier Data

Flow Cytometry - PE Anti-STRO1 antibody [STRO-1] (AB190282)

Flow Cytometry analysis of human peripheral blood labeling STRO1 with ab190282.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

STRO-1

Isotype

IgM

Conjugation

PE

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1-5 µg/mL", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/pe-mouse-igm-lambda-monoclonal-11e10-isotype-control-ab154448'>ab154448</a> - Mouse monoclonal IgM, is suitable for use as an isotype control with this antibody.</p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Size-exclusion chromatography
Purification notes
Purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Storage buffer
pH: 8 Preservative: 0.097% Sodium azide Constituents: 99% Tris buffered saline, 0.2% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store in the dark
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

STRO1 also known as Stem Cell Antigen STRO-1 acts as a cell surface marker instrumental in identifying mesenchymal stem cells (MSCs) within the bone marrow. The specific mass of STRO1 remains unknown although it is well-recognized for its presence on the surface of MSCs. Cells expressing STRO1 play key roles in the differentiation processes vital to tissue regeneration and repair. STRO1 expression can be found in various tissues such as bone marrow dental pulp and adipose tissue where stem cell proliferation is essential.
Biological function summary

Mesenchymal stem cells marked by STRO1 exhibit the capacity to differentiate into osteoblasts chondrocytes adipocytes and myocytes. STRO1 serves as a functional marker without a known part in a specific molecular complex. Its expression on MSCs aligns with its regulatory role in promoting tissue-specific differentiation. These properties indicate STRO1’s involvement in maintaining a regenerative environment necessary for tissue homeostasis and repair.

Pathways

Differentiation initiated by STRO1 expression interacts within bone and cartilage development pathways. In the bone formation pathway it plays a significant role by offering precursor cells like osteoblasts which differentiate from MSCs. Furthermore it associates indirectly with signaling regulated by proteins such as BMPs (Bone Morphogenetic Proteins). In another relevant pathway STRO1-expressing cells align with the Wnt signaling pathway a critical regulator of stem cell renewal and differentiation related processes.

Abnormalities in the differentiation potential of STRO1-positive cells contribute to the onset of diseases such as osteoporosis and osteoarthritis. Dysregulation in these pathways can impede normal regenerative functions affecting bone density and joint health. STRO1 is associated with the function of proteins like RUNX2 in osteoporosis which is essential for osteoblast differentiation. Another disease osteoarthritis connects through malfunctioning of mesenchymal progenitor cells impacting cartilage repair and involving proteins such as MMPs (Matrix Metalloproteinases).
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

See full target information STRO1
style
left-column

Publications (7)

Recent publications for all applications. Explore the full list and refine your search

BMC oral health 25:1155 PubMed40653466

2025

Piezo1 participates in the tension-driven osteogenic differentiation of periodontal ligament stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yugui Du,Junyi Zheng,Bowen Xu,Chuhan Peng,Kai Yang

International journal of molecular sciences 25: PubMed39769138

2025

Human Liver MSCs Retain Their Basic Cellular Properties in Chronically Inflamed Liver Tissue.

Applications

Unspecified application

Species

Unspecified reactive species

Yan S Kim,Alexey Yu Lupatov,Veronika V Burunova,Nikolay N Bagmet,Nikita K Chardarov,Svyatoslav L Malov,Roman V Kholodenko,Garnik A Shatverian,Garik V Manukyan,Konstantin N Yarygin,Irina V Kholodenko

Stem cells international 2024:7461604 PubMed39735214

2024

Transient Receptor Potential Ankyrin 1 (TRPA1) Mediated LPS-Induced Inflammation in Periodontal Ligament Stem Cells by Inhibiting the Phosphorylation of JNK.

Applications

Unspecified application

Species

Unspecified reactive species

Xian Wang,Xin Chen,Jie Gao,Zuolin Jin

Theranostics 8:5575-5592 PubMed30555565

2018

Alkaline Phosphatase Controls Lineage Switching of Mesenchymal Stem Cells by Regulating the LRP6/GSK3β Complex in Hypophosphatasia.

Applications

Unspecified application

Species

Unspecified reactive species

Wenjia Liu,Liqiang Zhang,Kun Xuan,Chenghu Hu,Liya Li,Yongjie Zhang,Fang Jin,Yan Jin

The American journal of pathology 188:2293-2306 PubMed30075150

2018

Expanding upon the Human Myometrial Stem Cell Hypothesis and the Role of Race, Hormones, Age, and Parity in a Profibroid Environment.

Applications

Unspecified application

Species

Unspecified reactive species

Lauren E Prusinski Fernung,Kimya Jones,Aymara Mas,Daniel Kleven,Jennifer L Waller,Ayman Al-Hendy

Stem cell research & therapy 9:131 PubMed29751774

2018

Changes in phenotype and differentiation potential of human mesenchymal stem cells aging in vitro.

Applications

Flow Cyt

Species

Human

Yueh-Hsun Kevin Yang,Courtney R Ogando,Carmine Wang See,Tsui-Yun Chang,Gilda A Barabino

Experimental neurology 295:222-232 PubMed28602834

2017

CNS disease diminishes the therapeutic functionality of bone marrow mesenchymal stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Alex Sargent,Lianhua Bai,Genevieve Shano,Molly Karl,Eric Garrison,Lahiru Ranasinghe,Sarah M Planchon,Jeffrey Cohen,Robert H Miller
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB216529

Alexa Fluor® 647 Anti-FABP4 antibody [EPR3579]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 647 Anti-FABP4 antibody [EPR3579] (AB216529)

  • 0
  • 0
Primary Antibodies

AB154448

PE Mouse IgM, lambda monoclonal [11E10] - Isotype control

  • 0
  • 0
Primary Antibodies

AB196450

Alexa Fluor® 488 Anti-SOX9 antibody [EPR14335]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 488 Anti-SOX9 antibody [EPR14335] (AB196450)

  • 4
  • 4
Primary Antibodies

AB214086

Anti-STRO1 antibody [STRO-1]

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com