PE Anti-STRO1 antibody [STRO-1]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

STRO1 also known as Stem Cell Antigen STRO-1 acts as a cell surface marker instrumental in identifying mesenchymal stem cells (MSCs) within the bone marrow. The specific mass of STRO1 remains unknown although it is well-recognized for its presence on the surface of MSCs. Cells expressing STRO1 play key roles in the differentiation processes vital to tissue regeneration and repair. STRO1 expression can be found in various tissues such as bone marrow dental pulp and adipose tissue where stem cell proliferation is essential.

Biological function summary

Mesenchymal stem cells marked by STRO1 exhibit the capacity to differentiate into osteoblasts chondrocytes adipocytes and myocytes. STRO1 serves as a functional marker without a known part in a specific molecular complex. Its expression on MSCs aligns with its regulatory role in promoting tissue-specific differentiation. These properties indicate STRO1’s involvement in maintaining a regenerative environment necessary for tissue homeostasis and repair.

Pathways

Differentiation initiated by STRO1 expression interacts within bone and cartilage development pathways. In the bone formation pathway it plays a significant role by offering precursor cells like osteoblasts which differentiate from MSCs. Furthermore it associates indirectly with signaling regulated by proteins such as BMPs (Bone Morphogenetic Proteins). In another relevant pathway STRO1-expressing cells align with the Wnt signaling pathway a critical regulator of stem cell renewal and differentiation related processes.

Associated diseases and disorders

Abnormalities in the differentiation potential of STRO1-positive cells contribute to the onset of diseases such as osteoporosis and osteoarthritis. Dysregulation in these pathways can impede normal regenerative functions affecting bone density and joint health. STRO1 is associated with the function of proteins like RUNX2 in osteoporosis which is essential for osteoblast differentiation. Another disease osteoarthritis connects through malfunctioning of mesenchymal progenitor cells impacting cartilage repair and involving proteins such as MMPs (Matrix Metalloproteinases).