Rabbit Recombinant Monoclonal TCF21 antibody - conjugated to PE.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application Target Binding Affinity | Reactivity Expected | Dilution info - | Notes - |
Application Antibody Labelling | Reactivity Expected | Dilution info - | Notes - |
Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.
BHLHA23, POD1, TCF21, Transcription factor 21, TCF-21, Capsulin, Class A basic helix-loop-helix protein 23, Epicardin, Podocyte-expressed 1, bHLHa23, Pod-1
Rabbit Recombinant Monoclonal TCF21 antibody - conjugated to PE.
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA
This product is a recombinant monoclonal antibody, which offers several advantages including:
For more information, read more on recombinant antibodies.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone. This conjugated antibody is eligible for the Abcam trial program.
TCF21 also known as Pod1 or capsulin is a transcription factor involved in gene regulation. It has a mass of approximately 25 kDa. TCF21 is primarily expressed in mesenchymal cells during development and in various tissues such as the lung heart and kidneys. It plays an important role in the developmental processes of these organs influencing the transcription of genes necessary for epithelial-mesenchymal transition (EMT).
TCF21 functions as a regulator of cellular differentiation and development. It is not part of a complex but acts independently as a transcription factor controlling the expression of target genes. During organogenesis TCF21 facilitates the differentiation of progenitor cells into specific cell lineages which are essential for proper organ formation. Through its interactions with DNA TCF21 modulates key developmental signals that guide cell fate determination and tissue remodeling.
TCF21 plays a role in the Wnt/β-catenin and TGF-β signaling pathways. In the Wnt/β-catenin pathway TCF21 interacts directly with β-catenin affecting the transcriptional activity of genes involved in cellular proliferation and differentiation. The TGF-β pathway also involves TCF21 where it influences signals that guide EMT and cellular migration. Additionally TCF21 collaborates with other proteins like GATA4 and TBX5 which further integrate its function into physiological processes.
TCF21 has been implicated in cancer progression and cardiovascular disease. Its downregulation is associated with several cancers including lung cancer where it may affect EMT and tumor metastasis. TCF21 mutations or alterations may contribute to cardiovascular disorders where its interaction with GATA4 influences heart development and disease susceptibility. Understanding the role of TCF21 in these contexts helps unravel its potential as a therapeutic target.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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