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Rabbit Recombinant Monoclonal TROP2 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human TACSTD2 aa 1-300.

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Images

Flow Cytometry - PE Anti-TROP2 antibody [001] (AB275728), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Conjugation

PE

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Storage buffer

Preservative: 0.09% Sodium azide
Constituents: 0.5% BSA

Form

Liquid

Clonality

Monoclonal

Immunogen

  • Recombinant Fragment Protein within Human TACSTD2 aa 1-300. The exact immunogen used to generate this antibody is proprietary information. Database link P09758

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
Flow Cyt
Human
Tested

Tested
Tested

Species

Human

Dilution info

-

Notes

5 μL/Test

Target data

Function

May function as a growth factor receptor.

Alternative names

Recommended products

Rabbit Recombinant Monoclonal TROP2 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human TACSTD2 aa 1-300.

Key facts

Isotype

IgG

Conjugation

PE

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Form

Liquid

Clonality

Monoclonal

Immunogen
  • Recombinant Fragment Protein within Human TACSTD2 aa 1-300. The exact immunogen used to generate this antibody is proprietary information. Database link P09758
Clone number

001

Purification technique

Affinity purification Protein A

Concentration
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Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Storage information

Do Not Freeze, Store in the dark

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

TROP2 also known as TACSTD2 or tumor-associated calcium signal transducer 2 is a single-pass type I membrane glycoprotein. This protein is about 35 kDa in mass and primarily expresses in epithelial tissues. It acts as a transmembrane receptor that plays a role in signal transduction due to its domain structure binding and activation processes on the cell surface. TROP2 exhibits high expression in several types of tumors making it a potential target for therapeutic antibodies like anti-TROP2 anti trop2 or anti-TROP-2.

Biological function summary

TROP2 mediates calcium signaling and cell proliferation. It functions by being a part of a signaling complex on the cell membrane which affects multiple cellular activities such as cell growth motility and survival. Its role in maintaining the integrity of the epithelial cell layer also shows TROP2's significance in normal tissue homeostasis. The interaction of TROP2 with the extracellular matrix and other cell surface proteins support the structural integrity and communication between cells.

Pathways

TROP2 plays a central role in the PI3K/AKT and MAPK signaling pathways that regulate cell growth and survival. Within these pathways TROP2 works in concert with proteins like ERK and AKT important for transmitting extracellular signals into appropriate cellular responses. These pathways are key regulators of many physiological processes including cell cycle progression and apoptosis prevention.

Associated diseases and disorders

TROP2 is strongly associated with several types of cancers particularly epithelial cancers like breast and pancreatic cancer. Overexpression of TROP2 in tumors often correlates with poor prognosis and aggressive disease phenotypes. Interaction between TROP2 and proteins like EGFR in cancer cell signaling pathways amplifies tumor progression and metastasis. Understanding these associations makes TROP2 a significant target in developing therapeutic strategies for cancer treatment.

Product promise

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1 product image

  • Flow Cytometry - PE Anti-TROP2 antibody [001] (ab275728), expandable thumbnail

    Flow Cytometry - PE Anti-TROP2 antibody [001] (ab275728)

    Flow cytometric analysis of ab275728 at 5 μl/Test on MCF7 (Human breast adenocarcinoma cell line) cells.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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