Anti-PEAR1 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

PEAR1 participates in the regulation of platelet activation and endothelial cell functions. It does not traditionally pair as part of a stable complex; however it interacts dynamically with various intracellular signaling molecules upon activation. This interaction influences the signaling cascade that governs platelet aggregation and the maintenance of vascular integrity. These processes are critical for normal physiological functions in cardiovascular systems.

Pathways

PEAR1 is integrated into the platelet activation pathway and the vascular endothelial growth factor (VEGF) signaling pathway. In the platelet activation pathway it interacts closely with other proteins such as integrins and various phospholipases which further transmit signals leading to platelet shape change and granule release. In the VEGF pathway it may indirectly influence endothelial responses although a more detailed map of interactions remains to be fully established.