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AB99468

Anti-PEBP4 antibody

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(3 Publications)

Goat Polyclonal PEBP4 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human PEBP4 aa 200 to C-terminus.

View Alternative Names

CORK1, UNQ1933/PRO4408, PEBP4, Phosphatidylethanolamine-binding protein 4, PEBP-4, hPEBP4, Protein cousin-of-RKIP 1

1 Images
Western blot - Anti-PEBP4 antibody (AB99468)
  • WB

Unknown

Western blot - Anti-PEBP4 antibody (AB99468)

All lanes:

Western blot - Anti-PEBP4 antibody (ab99468) at 1 µg/mL

All lanes:

Human Heart lysates at 35 µg

Predicted band size: 26 kDa

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Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human PEBP4 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q96S96

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-3 µg/mL", "WB-species-notes": "<p>A 1 hour primary incubation is recommended for this product. An additional band of unknown identity was also consistently observed at 30kDa. This band was successfully blocked by incubation with the immunizing peptide.</p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab99468 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PEBP4 also known as phosphatidylethanolamine-binding protein 4 is a protein that plays a role in intracellular signaling. It belongs to the PEBP family and has a molecular mass of approximately 21 kDa. PEBP4 is expressed in various human tissues with higher levels in the prostate lung and placenta. It functions by interacting with different signaling molecules and affecting their activity.
Biological function summary

PEBP4 modulates several cellular processes including apoptosis and cell proliferation. It is not known to be part of a larger complex but seems to exert its effects by binding to phospholipids and influencing signaling pathways. It shows interaction with several other molecules suggesting that it might have a regulatory role in cell survival and stress responses.

Pathways

This protein influences both the MAPK/ERK and apoptotic pathways. In the MAPK/ERK pathway PEBP4 interacts with key components to enhance cell survival signals. It is also associated with proteins like Raf-1 and MEK impacting their activity in cellular growth and differentiation. Through these pathways PEBP4 seems to control the balance between cell proliferation and apoptosis.

Research shows a relationship between PEBP4 and cancer as well as some inflammatory conditions. Increased expression of PEBP4 is observed in certain cancers including prostate and breast cancer. The protein's role in these diseases involves its impact on cellular survival pathways where it might increase cancer cell resistance to apoptosis. It also interacts with proteins like Bcl-2 which are involved in cell survival mechanisms and could contribute to the progression of cancerous conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Promotes AKT phosphorylation, suggesting a possible role in the PI3K-AKT signaling pathway.
See full target information PEBP4
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Andrology 13:331-341 PubMed38591173

2024

Knockout of phosphatidylethanolamine binding protein4 (PEBP4) promotes chronic non-bacterial prostatitis by mediating the activation of NF-κB signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Hailan He,Guancheng Xiao,Xing Hu,Hui Luo,Yunfeng Liao,Biao Qian,Guoxi Zhang,Xiaofeng Zou,Junrong Zou

Oncogene 33:4589-98 PubMed24276246

2013

Phosphatidylethanolamine-binding protein 4 is associated with breast cancer metastasis through Src-mediated Akt tyrosine phosphorylation.

Applications

IHC-P

Species

Human

H Li,F Huang,L Fan,Y Jiang,X Wang,J Li,Q Wang,H Pan,J Sun,X Cao,X Wang

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 32:1257-63 PubMed21887552

2011

The expression of PEBP4 protein in lung squamous cell carcinoma.

Applications

WB, IHC-P

Species

Human, Human

Gui-Ping Yu,Guo-Qiang Chen,Song Wu,Kai Shen,Yong Ji
View all publications
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Product promise

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