Rabbit Polyclonal PEG10/EDR antibody. Suitable for IP and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human PEG10 aa 300-400.
IgG
Rabbit
pH: 7 - 8
Preservative: 0.09% Sodium azide
Constituents: Tris citrate/phosphate
Liquid
Polyclonal
IP | |
---|---|
Human | Tested |
Chimpanzee | Predicted |
Dog | Predicted |
Giant Panda | Predicted |
Rhesus monkey | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 2-10 µg | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Dog, Chimpanzee, Rhesus monkey, Giant Panda | Dilution info - | Notes - |
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Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:34413232). Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232). Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232). Involved in placenta formation: required for trophoblast stem cells differentiation (By similarity). Involved at the immediate early stage of adipocyte differentiation (By similarity). Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (PubMed:12810624, PubMed:16423995, PubMed:26235627, PubMed:28193232). Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (PubMed:15611116, PubMed:26235627, PubMed:30094509). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (By similarity).
EDR, KIAA1051e, MAR2, MART2, MEF3L1, RGAG3, PEG10, Retrotransposon-derived protein PEG10, Embryonal carcinoma differentiation-regulated protein, Mammalian retrotransposon-derived protein 2, Myelin expression factor 3-like protein 1, Paternally expressed gene 10 protein, Retrotransposon gag domain-containing protein 3, Retrotransposon-derived gag-like polyprotein, Ty3/Gypsy-like protein, MEF3-like protein 1
Rabbit Polyclonal PEG10/EDR antibody. Suitable for IP and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human PEG10 aa 300-400.
IgG
Rabbit
pH: 7 - 8
Preservative: 0.09% Sodium azide
Constituents: Tris citrate/phosphate
Liquid
Polyclonal
Affinity purification Immunogen
ab226370 was affinity purified using an epitope specific to PEG10/EDR immobilized on solid support.
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
ab226370 has not performed satisfactorily when used for WB of PEG10/EDR in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of PEG10/EDR.
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This supplementary information is collated from multiple sources and compiled automatically.
PEG10 also known as EDR2 is a paternally expressed imprinted gene that encodes the PEG10 protein. The PEG10 protein has a molecular mass of approximately 150 kDa. It shows expression most notably in the placenta during development but also in other tissues like the liver and brain. The protein contains two open reading frames that produce different products via a frameshift mechanism similar to retroviral proteins.
The PEG10 protein plays multiple roles especially in cell proliferation apoptosis inhibition and promoting cell survival. It can be part of larger protein complexes that modulate cellular responses to stress and developmental cues. The protein's multifaceted activities are important during embryogenesis where it supports trophoblast development and placental formation.
PEG10 interacts with signaling cascades such as the TGF-beta signaling pathway and is involved in cell cycle regulation. PEG10 works alongside proteins like paternally expressed genes that connect with TGF-beta pathways influencing cellular differentiation and growth. Its integration in these pathways highlights its role in managing cellular environments and responses to cellular stress signals.
PEG10 expression over-activation has associations with cancer especially hepatocellular carcinoma and pancreatic cancer. In these contexts PEG10 interacts with proteins like H3L3 contributing to oncogenic pathways that drive tumor cell proliferation and survival. Elevated levels of PEG10 can serve as potential biomarkers for certain cancers suggesting their role in disease progression and possible therapeutic targeting.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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Terms & Conditions.
PEG10/EDR was immunoprecipitated from HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate (prepared using NETN lysis buffer; 20% of IP loaded) with ab226370 at 6 μg per reaction. Western blot was performed from the immunoprecipitate using ab226370 at 0.4 μg/ml.
Lane 1: ab226370 IP in HeLa whole cell lysate.
Lane 2: Control IgG IP in HeLa whole cell lysate.
Detection: Chemiluminescence with exposure time of 3 minutes.
All lanes: Immunoprecipitation - Anti-PEG10/EDR antibody (ab226370)
Predicted band size: 80 kDa
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