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AB126982

Anti-Pellino 2 antibody

4

(1 Review)

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(1 Publication)

Rabbit Polyclonal Pellino 2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PELI2 aa 150-400.

View Alternative Names

E3 ubiquitin-protein ligase pellino homolog 2, Pellino-2, RING-type E3 ubiquitin transferase pellino homolog 2, PELI2

1 Images
Western blot - Anti-Pellino 2 antibody (AB126982)
  • WB

Unknown

Western blot - Anti-Pellino 2 antibody (AB126982)

10% SDS PAGE

All lanes:

Western blot - Anti-Pellino 2 antibody (ab126982) at 1/500 dilution

All lanes:

HeLa whole cell lysate at 30 µg

Predicted band size: 46 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human PELI2 aa 150-400. The exact immunogen used to generate this antibody is proprietary information.

Q9HAT8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Pellino 2 also known as PELI2 is an E3 ubiquitin ligase. It is about 45 kDa in mass and exists in the cytoplasm. This protein plays an important role in the regulation of the innate immune response. It is highly expressed in immune cells like monocytes and macrophages as well as in tissues such as the spleen and lymph nodes. As an adaptor molecule Pellino 2 modifies proteins by attaching ubiquitin which tags them for degradation or alters their activity.
Biological function summary

Pellino 2 engages in downstream signaling of immune receptors. It has a critical role in the activation of transcription factors contributing to the production of pro-inflammatory cytokines. Acting in a complex with other components like TRAF proteins it regulates the nuclear factor kappa B (NF-kB) signaling pathway. Through this regulation Pellino 2 influences inflammatory responses and aids in controlling the duration and intensity of inflammation.

Pathways

Pellino 2 integrates into the Toll-like receptor (TLR) and interleukin-1 (IL-1) signaling pathways. These pathways are fundamental for initiating the innate immune response upon detecting pathogens. Pellino 2 interacts with proteins like IRAK4 and MyD88 in these pathways facilitating the activation and amplification of signal cascades that lead to NF-kB and mitogen-activated protein kinase (MAPK) activation which further influence gene expression and immune responses.

Pellino 2 links with inflammatory conditions such as rheumatoid arthritis and cardiovascular disease. Abnormal regulation or expression of Pellino 2 may enhance inflammatory signaling contributing to the pathogenesis of these disorders. The protein's interaction with NF-kB an important player in many inflammatory diseases makes it an important factor in understanding and potentially modulating these pathological processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.
See full target information PELI2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Aging 10:463-480 PubMed29615536

2018

Protective effects of melatonin against nicotine-induced disorder of mouse early folliculogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Feng Wang,Xiao-Feng Sun,Ze-Li Han,Lan Li,Wei Ge,Yong Zhao,Massimo De Felici,Wei Shen,Shun-Feng Cheng
View all publications
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